{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:53:07Z","timestamp":1773327187893,"version":"3.50.1"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT   Background: Gastroesophageal reflux disease is defined by the abnormal presence of gastric content in the esophagus, with 10% incidence in the Western population, being fundoplication one treatment option.   Aim: To evaluate the early (six months) and late (15 years) effectiveness of laparoscopic fundoplication, the long term postoperative weight changes, as well as the impact of weight gain in symptoms control.   Methods:  Prospective study of 40 subjects who underwent laparoscopic Nissen\u2019s fundoplication. Preoperatively and early postoperatively, clinical, endoscopic, radiologic, manometric and pHmetric evaluations were carried out. After 15 years, clinical and endoscopic assessments were carried out and the results compared with the early ones. The presence or absence of obesity was stratified in both early and late phases, and its influence in the long-term results of fundoplication was studied, measuring quality of life according to the Visick criteria.   Results:  The mean preoperative ages, weight, and body mass index were respectively, 51 years, 69.67 kg and 25.68 kg\/m2. The intraoperative and postoperative complications rates were 12.5% and 15%, without mortality. In the early postoperative period the symptoms were well controlled, hernias and esophagitis disappeared, the lower esophageal sphincter had functional improvement, and pHmetry parameters normalized. In the late follow-up 29 subjects were assessed. During this period there was adequate clinical control of reflux regardless of weight gain. In both time periods Visick criteria improved.   Conclusion:  Fundoplication was safe and effective in early and late periods. There was late weight gain, which did not influence effective symptoms control.<\/jats:p>","DOI":"10.1590\/0102-672020190001e1488","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T23:29:09Z","timestamp":1589930949000},"source":"Crossref","is-referenced-by-count":1,"title":["Does weight gain, throughout 15 years follow-up after Nissen laparoscopic fundoplication, compromise reflux symptoms control?"],"prefix":"10.1590","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-5150","authenticated-orcid":false,"given":"Victor Ramos Mussa","family":"DIB","sequence":"first","affiliation":[{"name":"Victor Dib Institute,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-1750","authenticated-orcid":false,"given":"Almino Cardoso","family":"RAMOS","sequence":"additional","affiliation":[{"name":"Gastro Obeso Center,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2541-8978","authenticated-orcid":false,"given":"Nilton Tokio","family":"KAWAHARA","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josemberg Marins","family":"CAMPOS","sequence":"additional","affiliation":[{"name":"Federal University of Pernambuco,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6914-6273","authenticated-orcid":false,"given":"Jo\u00e3o Caetano","family":"MARCHESINI","sequence":"additional","affiliation":[{"name":"Caetano Marchesini Clinic,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel","family":"GALV\u00c3O-NETO","sequence":"additional","affiliation":[{"name":"Gastro Obeso Center,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6753-5507","authenticated-orcid":false,"given":"Adriana Gon\u00e7alves Daumas Pinheiro","family":"GUIMAR\u00c3ES","sequence":"additional","affiliation":[{"name":"Airforce Surgical Center,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano Pessoa","family":"PICAN\u00c7O-JUNIOR","sequence":"additional","affiliation":[{"name":"Federal University of Amazonas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-569X","authenticated-orcid":false,"given":"Carlos Eduardo","family":"DOMENE","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/lap.2016.0322","article-title":"Laparoscopic Antireflux Surgery Importance Of Patient's Selection And Preoperative Workup","volume":"27","author":"Andolfi C","year":"2017","journal-title":"Journal Of Laparoendoscopic & Advanced Surgical Techniques Part A"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s005950170201","article-title":"Type Iv Hiatal Hernia Post Laparoscopic Nissen Fundoplication Report Of A Case","volume":"31","author":"Awad Zt","year":"2001","journal-title":"Surgery Today"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1590\/0102-672020190001e1440","article-title":"Failure After Fundoplication: Re-Fundoplication? Is There A Room For Gastrectomy? In Which Clinical Scenaries","volume":"32","author":"Braghetto I","year":"2019","journal-title":"Abcd, Arq. Bras. Cir. Dig"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/gut.2010.224824","article-title":"Effects Of Anti-Reflux Surgery On Weakly Acidic Reflux And Belching","volume":"60","author":"Ja Broeders","year":"2011","journal-title":"Gut"},{"issue":"3","key":"ref5","first-page":"400","article-title":"Laparoscopic Nissen Fundoplication Technique And Preliminary Results.the British Journal Of","volume":"81","author":"Cadiere Gb","year":"1994","journal-title":"Surgery"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1091-255X(99)80071-7","article-title":"Multivariate Analysis Of Factors Predicting Outcome After Laparoscopic Nissen Fundoplication","volume":"3","author":"Campos Gm","year":"1999","journal-title":"Journal Of Gastrointestinal Surgery : Official Journal Of The Society For Surgery Of The Alimentary Tract"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1007\/s00464-008-0271-8","article-title":"The Use Of Medication After Laparoscopic Antireflux Surgery","volume":"23","author":"Ciovica R","year":"2009","journal-title":"Surgical Endoscopy"},{"issue":"3","key":"ref8","first-page":"138","article-title":"Laparoscopic Nissen Fundoplication Preliminary Report","volume":"1","author":"Dallemagne B","year":"1991","journal-title":"Surgical Laparoscopy & Endoscopy"},{"issue":"20","key":"ref9","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1001\/archinte.1995.00430200044008","article-title":"Guidelines For The Diagnosis And Treatment Of Gastroesophageal Reflux Disease Practice Parameters Committee Of The American College Of Gastroenterology","volume":"155","author":"Devault Kr","year":"1995","journal-title":"Archives Of Internal Medicine"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1442-2050.2001.00157.x","article-title":"Obesity And Its Effect On Outcome Of Laparoscopic Nissen Fundoplication","volume":"14","author":"Fraser J","year":"2001","journal-title":"Diseases Of The Esophagus : Official Journal Of The International Society For Diseases Of The Esophagus \/ Isde"},{"issue":"5","key":"ref11","first-page":"482","article-title":"Measuring The Effectiveness Of Laparoscopic Antireflux Surgery Long-Term Results","volume":"143","author":"Gee Dw","year":"2008","journal-title":"Archives Of Surgery (Chicago, Ill : 1960)"},{"issue":"11","key":"ref12","first-page":"1150","article-title":"[Gerd And Complications: When Is Surgery Necessary?]","volume":"45","author":"Ah Holscher","year":"2007","journal-title":"Zeitschrift Fur Gastroenterologie"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/bjs.1800800118","article-title":"Outcome 5 Years After 360 Degree Fundoplication For Gastro-Oesophageal Reflux Disease","volume":"80","author":"Johansson J","year":"1993","journal-title":"The British Journal Of Surgery"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.soard.2006.08.011","article-title":"Anatomic Findings And Outcomes After Antireflux Procedures In Morbidly Obese Patients Undergoing Laparoscopic Conversion To Roux-En-Y Gastric Bypass","volume":"3","author":"Ta Kellogg","year":"2007","journal-title":"Surgery For Obesity And Related Diseases : Official Journal Of The American Society For Bariatric Surgery"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.3748\/wjg.v22.i4.1627","article-title":"Impact Of Obesity Treatment On Gastroesophageal Reflux Disease","volume":"22","author":"Khan A","year":"2016","journal-title":"World Journal Of Gastroenterology"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.cgh.2009.05.021","article-title":"Comparison Of Outcomes Twelve Years After Antireflux Surgery Or Omeprazole Maintenance Therapy For Reflux Esophagitis","volume":"7","author":"Lundell L","year":"2009","journal-title":"Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association"},{"issue":"6","key":"ref17","first-page":"517","article-title":"Barrett's Esophagus After Laparoscopic Nissen-Rossetti Fundoplication Functional Evaluation","volume":"66","author":"Marano S","year":"2011","journal-title":"Minerva Chirurgica"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4240\/wjgs.v8.i1.77","article-title":"Gastroesophageal Reflux Disease A Review Of Surgical Decision Making","volume":"8","author":"Moore M","year":"2016","journal-title":"World Journal Of Gastrointestinal Surgery"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1590\/S0004-28032005000200011","article-title":"Prevalence Of Heartburn And Gastroesophageal Reflux Disease In The Urban Brazilian Population","volume":"42","author":"Jp Moraes-Filho","year":"2005","journal-title":"Arquivos De Gastroenterologia"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","DOI":"10.1590\/0102-672020190001e1453","article-title":"Is There Any Change In Phenotypic Characteristics Comparing 5 To 10 Years Of Follow-Up In Obese Patients Undergoing Roux-En-Y Gastric Bypass?","volume":"32","author":"Nonino Cb","year":"2019","journal-title":"Abcd, Arq. Bras. Cir. Dig"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jamcollsurg.2004.01.029","article-title":"Total Fundoplication Is Superior To Partial Fundoplication Even When Esophageal Peristalsis Is Weak","volume":"198","author":"Mg Patti","year":"2004","journal-title":"journal Of The American College Of Surgeons"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/s004640000392","article-title":"Obesity Adversely Affects The Outcome Of Antireflux Operations","volume":"15","author":"Perez Ar","year":"2001","journal-title":"Surgical Endoscopy"},{"issue":"1","key":"ref23","first-page":"93","article-title":"The Emerging Epidemic Of Obesity In Developing Countries international Journal Of","volume":"35","author":"Prentice Am","year":"2006","journal-title":"Epidemiology"},{"issue":"10","key":"ref24","first-page":"1373","article-title":"Laparoscopic Gastric Bypass After Antireflux Surgery For The Treatment Of Gastroesophageal Reflux In Morbidly Obese Patients Initial Experience.obesity","volume":"14","author":"Raftopoulos I","year":"2004","journal-title":"Surgery"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1590\/S0004-28032011000400007","article-title":"Surgical Treatment Of Gastroesophageal Reflux Disease Total Or Partial Fundoplication?","volume":"48","author":"Ramos Rf","year":"2011","journal-title":"Systematic Review And Meta-Analysis.arquivos De Gastroenterologia"},{"key":"ref26","first-page":"131","author":"Resa Jj","year":"2004"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1080\/00365520801935467","article-title":"The Visick Score A Good Measure For The Overall Effect Of Antireflux Surgery?","volume":"43","author":"Hg Rijnhart-De Jong","year":"2008","journal-title":"Scandinavian Journal Of Gastroenterology"},{"issue":"18","key":"ref28","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1001\/jama.285.18.2331","article-title":"Long-Term Outcome Of Medical And Surgical Therapies For Gastroesophageal Reflux Disease Follow-Up Of A Randomized Controlled Trial","volume":"285","author":"Spechler Sj","year":"2001","journal-title":"Jama"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1007\/s00464-010-1267-8","article-title":"Guidelines For Surgical Treatment Of Gastroesophageal Reflux Disease","volume":"24","author":"Stefanidis D","year":"2010","journal-title":"Surgical Endoscopy"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1055\/s-2007-963633","article-title":"[The Montreal Definition And Classification Of Gastroesophageal Reflux Disease: A Global, Evidence-Based Consensus Paper]","volume":"45","author":"Vakil N","year":"2007","journal-title":"Zeitschrift Fur Gastroenterologie"},{"issue":"5","key":"ref31","first-page":"410","article-title":"Comparison Of Nissen Total And Lind Partial Transabdominal Fundoplication In The Treatment Of Gastro-Oesophageal Reflux the British Journal Of","volume":"79","author":"Sj Walker","year":"1992","journal-title":"Surgery"},{"issue":"5","key":"ref32","first-page":"651","article-title":"Laparoscopic 'Physiological' Antireflux Procedure Preliminary Results Of A Prospective Symptomatic And Objective Study.the British Journal Of","volume":"82","author":"Watson A","year":"1995","journal-title":"Surgery"},{"issue":"11","key":"ref33","first-page":"2177","article-title":"Objective Follow-Up After Laparoscopic Repair Of Large Type Iii Hiatal Hernia","volume":"31","author":"Zaninotto G","year":"2007","journal-title":"Assessment Of Safety And Durability.world Journal Of Surgery"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","DOI":"10.1590\/0102-672020190001e1450","article-title":"Critical Analysis Of Surgical Treatment Tech-niques Of Morbid Obesity","volume":"32","author":"Zilberstein B","year":"2019","journal-title":"Abcd, Arq. Bras. Cir. Dig"}],"container-title":["ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo)"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abcd\/v33n1\/0102-6720-abcd-33-01-e1488.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T19:51:01Z","timestamp":1611431461000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-67202020000100302&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020]]}},"alternative-id":["S0102-67202020000100302"],"URL":"https:\/\/doi.org\/10.1590\/0102-672020190001e1488","relation":{},"ISSN":["2317-6326","0102-6720"],"issn-type":[{"value":"2317-6326","type":"electronic"},{"value":"0102-6720","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e1488"}}