{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:33:45Z","timestamp":1780079625969,"version":"3.54.0"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT   Background:  Incidental gallbladder cancer is defined as a cancer discovered by histological examination after cholecystectomy. It is a potentially curable disease. However, some questions related to their management remain controversial and a defined strategy is associated with better prognosis.  Aim: To develop the first evidence-based consensus for management of patients with incidental gallbladder cancer in Brazil.   Methods:  Sixteen questions were selected, and 36 Brazilian and International members were included to the answer them. The statements were based on current evident literature. The final report was sent to the members of the panel for agreement assessment.   Results: Intraoperative evaluation of the specimen, use of retrieval bags and routine histopathology is recommended. Complete preoperative evaluation is necessary and the reoperation should be performed once final staging is available. Evaluation of the cystic duct margin and routine 16b1 lymph node biopsy is recommended. Chemotherapy should be considered and chemoradiation therapy if microscopically positive surgical margins. Port site should be resected exceptionally. Staging laparoscopy before reoperation is recommended, but minimally invasive radical approach only in specialized minimally invasive hepatopancreatobiliary centers. The extent of liver resection is acceptable if R0 resection is achieved. Standard lymph node dissection is required for T2 tumors and above, but common bile duct resection is not recommended routinely.  Conclusions: It was possible to prepare safe recommendations as guidance for incidental gallbladder carcinoma, addressing the most frequent topics of everyday work of digestive and general surgeons.<\/jats:p>","DOI":"10.1590\/0102-672020190001e1496","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T14:01:21Z","timestamp":1594216881000},"source":"Crossref","is-referenced-by-count":22,"title":["BRAZILIAN CONSENSUS ON INCIDENTAL GALLBLADDER CARCINOMA"],"prefix":"10.1590","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5068-0639","authenticated-orcid":false,"given":"Felipe Jose F","family":"COIMBRA","sequence":"first","affiliation":[{"name":"AC Camargo Cancer Center,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-5395","authenticated-orcid":false,"given":"Orlando Jorge M","family":"TORRES","sequence":"additional","affiliation":[{"name":"Federal University of Maranh\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8602-514X","authenticated-orcid":false,"given":"Ruslan","family":"ALIKHANOV","sequence":"additional","affiliation":[{"name":"Moscow Clinical Scientific Center,  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-1526","authenticated-orcid":false,"given":"Anil","family":"AGARWAL","sequence":"additional","affiliation":[{"name":"Govind Ballabh Pant Hospital,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5635-7437","authenticated-orcid":false,"given":"Patrick","family":"PESSAUX","sequence":"additional","affiliation":[{"name":"University Hospital of Strasbourg,  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1304-5075","authenticated-orcid":false,"given":"Eduardo de Souza 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AK","year":"2012","journal-title":"HPB"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/SLA.0b013e318271497e","article-title":"The role of staging laparoscopy in primary gall bladder cancer - An analysis of 409 patients A prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer","volume":"258","author":"Agarwal AK","year":"2013","journal-title":"Ann Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/hpb.12127","article-title":"Role of routine 16b1 lymph node biopsy in the management of gallbladder cancer an analysis","volume":"16","author":"Agarwal AK","year":"2014","journal-title":"HPB"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/hpb.12406","article-title":"Minimally invasive versus the conventional open surgical approach of a radical cholecystectomy for gallbladder cancer a retrospective comparative study","volume":"17","author":"Agarwal AK","year":"2015","journal-title":"HPB"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00534-009-0044-3","article-title":"Hepatic resection in 485 R0 pT2 and pT3 cases of advanced carcinoma of the gallbladder results of a Japanese Society of Biliary Surgery survey-a multicenter study","volume":"16","author":"Araida T","year":"2009","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s00268-013-2266-4","article-title":"Patterns of failure and determinants of outcomes following radical re-resection for incidental gallbladder cancer","volume":"38","author":"Barreto SG","year":"2014","journal-title":"World J Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1200\/JCO.2014.60.2219","article-title":"SWOG S0809 A phase II intergroup trial of adjuvant capecitabine and gemcitabine followed by radiotherapy and concurrent capecitabine in extrahepatic cholangiocarcinoma and gallbladder carcinoma","volume":"33","author":"Ben-Josef E","year":"2014","journal-title":"J Clin Oncol"},{"key":"ref9","first-page":"1","article-title":"Intraoperative bile spillage is associated with worse survival in gallbladder adenocarcinoma","author":"Blakely AM","year":"2019","journal-title":"J Surg Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1477-2574.2011.00325.x","article-title":"The role of laparoscopic staging in patients with incidental gallbladder cancer","volume":"13","author":"Butte JM","year":"2011","journal-title":"HPB"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.dld.2013.07.004","article-title":"Pathology report assessment of incidental gallbladder carcinoma diagnosed from cholecystectomy specimens results of a French multicentre survey","volume":"45","author":"Chatelain D","year":"2013","journal-title":"Dig Liver Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s00423-013-1120-3","article-title":"Surgical strategy for T2 and T3 gallbladder cancer is extrahepatic bile duct resection always necessary?","volume":"398","author":"Choi SB1","year":"2013","journal-title":"Langenbecks Arch Surg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/jamasurg.2016.3642","article-title":"Association of optimal time interval to re-resection for incidental gallbladder cancer with overall survival A multi-institution analysis from the US extrahepatic biliary malignancy consortium","volume":"152","author":"Ethun CG","year":"2017","journal-title":"JAMA Surg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/jso.24591","article-title":"Routine port-site excision in incidentally discovered gallbladder cancer is not associated with improved survival A multi-institution analysis from the US Extrahepatic Biliary Malignancy 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