{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:44:08Z","timestamp":1773110648743,"version":"3.50.1"},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT  Background:  There is still a need for progress in the treatment of transsphincteric anal fistulae and the use of herbal medicines seems promising.  Aim:  To evaluate the efficacy of Stryphnodendron adstringens associated with fistulotomy and primary sphincteroplasty in the treatment of transsphincteric fistulae in rats.  Methods: Thirty Wistar rats were used, which were submitted to transsphincteric fistulas with steel wire 0; after 30 days a treatment was performed according to the group. Group A (n=10) was submitted to fistulotomy; group B (n=10), fistulotomy followed by primary sphincteroplasty with \u201cU\u201d stitch with polyglactin 911 4-0; group C(n=10) , similar to group B, but with the interposition between the muscular stumps of hemostatic sponge soaked in Stryphnodendron adstringens extract. Euthanasia was performed after 14 days, resecting a segment of the anal canal for histological analysis, which aimed to evaluate the closure of the fistula, the area of separation of the muscle cables, the inflammatory process and the degree of fibrosis.  Results:  No animal had a remaining fistulous tract. About the spacing between the muscle cables, an average of 106.3 \u00b5m2 was observed in group A, 82.8 \u00b5m2 in group B and 51.8 \u00b5m2 in group C (p&lt;0.05). There was no difference between the groups regarding the inflammatory process and, in relation to fibrosis, in group A there was a mean of 0.6, in group B 0.7 and in group C 0.2 (p&lt;0.05).  Conclusions: Stryphnodendron adstringens extract was able to allow less spacing between muscle cables in rats submitted to fistulotomy followed by primary sphincteroplasty, in addition to providing less local fibrosis.<\/jats:p>","DOI":"10.1590\/0102-672020200003e1540","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T16:45:54Z","timestamp":1608309954000},"source":"Crossref","is-referenced-by-count":2,"title":["CAN Stryphnodendron adstringens EXTRACT IMPROVE THE RESULTS OF FISTULOTOMY FOLLOWED BY PRIMARY SPHINCTEROPLASTY IN THE TREATMENT OF TRANSSPHINCTERIC FISTULAE?"],"prefix":"10.1590","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8786-6442","authenticated-orcid":false,"given":"Adriana de Souza","family":"R\u00d3S","sequence":"first","affiliation":[{"name":"Federal University of Mato Grosso do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-7329","authenticated-orcid":false,"given":"Carlos Henrique Marques dos","family":"SANTOS","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul,  Brazil; Anhanguera-Uniderp University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-6046","authenticated-orcid":false,"given":"Doroty Mesquita","family":"DOURADO","sequence":"additional","affiliation":[{"name":"Anhanguera-Uniderp University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0990-9275","authenticated-orcid":false,"given":"Mois\u00e9s Soares da","family":"SILVA-NETO","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-4929","authenticated-orcid":false,"given":"Isabela","family":"CALDEIRA","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7448-5520","authenticated-orcid":false,"given":"Leandro de Oliveira","family":"FURTADO","sequence":"additional","affiliation":[{"name":"Anhanguera-Uniderp University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1590\/0102-6720201700040002","article-title":"Interesfincteric ligation of fistula tract (LIFT) for patients with anal fistulas: a Brazilian bi-institutional experience","volume":"30","author":"Araujo SEA","year":"2017","journal-title":"Arq Bras Cir Dig"},{"issue":"1","key":"ref2","first-page":"159","article-title":"Efeito da pomada de barbatim\u00e3o (Stryphnodendron barbatiman martius) associado ao ultrassom de baixa intensidade sobre a cicatriza\u00e7\u00e3o por segunda inten\u00e7\u00e3o de les\u00f5es cut\u00e2neas totais em ratos","volume":"6","author":"Ballaben AS","year":"2013","journal-title":"Revista Uniara"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s10151-019-02122-7","article-title":"Long-term outcome of sphincteroplasty with separate suturing of the internal and the external anal sphincter","volume":"23","author":"Berg MR","year":"2019","journal-title":"Tech Coloproctol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ijscr.2013.04.004","article-title":"Anal fistula with foot extension - treated by khhara sutra (medicated seton) therapy A rare case report","volume":"4","author":"Bhat RP","year":"2013","journal-title":"Int J Surg Case Reports"},{"key":"ref5","first-page":"1","article-title":"Fistulectomy and primary sphincteroplasty (FIPS) to prevent keyhole deformity in simple anal fistula a single-center retrospective cohort study","volume":"7","author":"De Hous N","year":"2020","journal-title":"Acta Chir Belg"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"406","DOI":"10.4103\/0976-9668.160022","article-title":"Comparing Ksharasutra (Ayurvedic Seton) and open fistulotomy in the management of fistula-in-ano","volume":"6","author":"Dutta G","year":"2015","journal-title":"J Nat Sci Biol Med"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.asjsur.2018.12.005","article-title":"One stage fistulectomy for high anal fistula with reconstruction of anal sphincter without fecal diversion","volume":"42","author":"Farag AFA","year":"2019","journal-title":"Asian J Surg"},{"issue":"216","key":"ref8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jep.2018.01.008","article-title":"Proanthocyanidin polymeric tannins from Stryphnodendron adstringens are effective against Candida spp. isolates and for vaginal candidiasis treatment","volume":"24","author":"Freitas ALD","year":"2018","journal-title":"J Ethnopharmacol"},{"issue":"254","key":"ref9","doi-asserted-by":"crossref","first-page":"112684","DOI":"10.1016\/j.jep.2020.112684","article-title":"Hydroethanolic stem bark extracts of Stryphnodendron adstringens impair M1 macrophages and promote M2 polarization","volume":"23","author":"Giffoni de Carvalho JT","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"9872598","DOI":"10.1155\/2016\/9872598","article-title":"In Vitro TNF-a Inhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect of Stryphnodendron adstringens in an Acute Arthritis Model","volume":"2016","author":"Henriques BO","year":"2016","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref11","first-page":"6132340","article-title":"Stem Cell Therapy A Compassionate Use Program in Perianal Fistula","author":"Herreros MD","year":"2019","journal-title":"Stem Cells Int. 2019; 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