{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:43:17Z","timestamp":1768516997828,"version":"3.49.0"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT  BACKGROUND: Enteroendocrine L cells can be found in the entire gastrointestinal tract and their incretins act on glycemic control and metabolic homeostasis. Patients with severe obesity and type 2 diabetes mellitus may have lower density of L cells in the proximal intestine.  AIMS: This study aimed to analyze the density of L cells in the segments of the small intestine in the late postoperative of Roux-en-Y gastric bypass in diabetic patients with standardization of 60 cm in both loops, alimentary and biliopancreatic.  METHODS: Immunohistochemistry analysis assays were made from intestinal biopsies in three segments: gastrointestinal anastomosis (GIA= Point A), enteroenteral anastomosis (EEA= Point B= 60 cm distal to the GIA) and 60 cm distal to the enteroenteral anastomosis (Point C).  RESULTS: A higher density of L cells immunostaining the glucagon-1 peptide was observed in the distal portion (Point C) when compared to the more proximal portions (Points A and B).  CONCLUSIONS: The concentration of L cells is higher 60 cm distal to enteroenteral anastomosis when comparing to proximal segments and may explain the difference in intestinal lumen sensitization and enterohormonal response after Roux-en-Y gastric bypass.<\/jats:p>","DOI":"10.1590\/0102-672020220002e1681","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T20:44:48Z","timestamp":1664829888000},"source":"Crossref","is-referenced-by-count":2,"title":["SMALL INTESTINAL L CELL DENSITY IN PATIENTS WITH SEVERE OBESITY AFTER ROUX-EN-Y GASTRIC BYPASS"],"prefix":"10.1590","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3911-7866","authenticated-orcid":false,"given":"Priscila Costa","family":"Estabile","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-6210","authenticated-orcid":false,"given":"Marco Aur\u00e9lio","family":"Santo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-3722","authenticated-orcid":false,"given":"Eduardo Guimar\u00e3es Horneaux de","family":"Moura","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-1946","authenticated-orcid":false,"given":"Rog\u00e9rio","family":"Kuga","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-193X","authenticated-orcid":false,"given":"Priscila","family":"Caproni","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-9014","authenticated-orcid":false,"given":"Roberto de","family":"Cleva","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-6345","authenticated-orcid":false,"given":"Filippe Camarotto","family":"Mota","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-3156","authenticated-orcid":false,"given":"F\u00e1bio Quirillo","family":"Mill\u00e9o","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Ponta Grossa,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-9846","authenticated-orcid":false,"given":"Roberto Ferreira","family":"Artoni","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Ponta Grossa,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s11695-019-04280-x","article-title":"Is revisional gastric bypass as effective as primary gastric bypass for weight loss and improvement of comorbidities?","volume":"30","author":"Abdulrazzaq 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gastric inhibitory polypeptide in the duodenum and jejunum","volume":"14","author":"Polak JM","year":"1973","journal-title":"Gut"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1007\/s00125-015-3696-3","article-title":"Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes","volume":"58","author":"Rhee NA","year":"2015","journal-title":"Diabetologia"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1590\/0102-672020190001e1503","article-title":"Does evolutionary biology help the understanding of metabolic surgery? A focused review","volume":"33","author":"Santoro S","year":"2020","journal-title":"ABCD Arq Bras Cir Dig"}],"container-title":["ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo)"],"original-title":["AVALIA\u00c7\u00c3O DA DENSIDADE DAS C\u00c9LULAS L NO INTESTINO DELGADO EM OBESOS GRAVES AP\u00d3S GASTROPLASTIA EM Y-DE-ROUX"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-67202022000100334&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T20:45:09Z","timestamp":1664829909000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-67202022000100334&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":19,"alternative-id":["S0102-67202022000100334"],"URL":"https:\/\/doi.org\/10.1590\/0102-672020220002e1681","relation":{},"ISSN":["2317-6326","0102-6720"],"issn-type":[{"value":"2317-6326","type":"electronic"},{"value":"0102-6720","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e1681"}}