{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:02:36Z","timestamp":1781762556220,"version":"3.54.5"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT  BACKGROUND: Dysbiosis of the gut microbiota is frequently found in cases of obesity and related metabolic diseases, such as type 2 diabetes mellitus. The composition of the microbiota in diabetics is similar to that of obese people, thereby causing increased energy uptake efficiency in the large intestine of obese people, maintenance of a systemic inflammatory state, and increased insulin resistance. Bariatric surgery seems to entail an improvement in gut dysbiosis, leading to an increased diversity of the gut microbiota.  AIMS: This study aimed to present a literature review on obesity-associated gut dysbiosis and its status post-bariatric surgery.  METHODS: A systematic review of primary studies was conducted in PubMed, SciELO, BIREME, LILACS, Embase, ScienceDirect, and Scopus databases using DeCS (Health Science Descriptors) with the terms \u201cobesity,\u201d \u201cintestinal dysbiosis,\u201d \u201cbariatric surgery,\u201d and \u201cmicrobiota.\u201d  RESULTS: We analyzed 28 articles that had clinical studies or literature reviews as their main characteristics, of which 82% (n=23) corresponded to retrospective studies. The sample size of the studies ranged from 9 to 257 participants and\/or fecal samples. The epidemiological profile showed a higher prevalence of obesity in females, ranging from 24.4 to 35.1%, with a mean age of around 25\u201340 years. There was a variation regarding the type of bariatric surgery, migrating between the Roux-en-Y bypass, adjustable gastric banding, and vertical gastrectomy. Of the 28 studies, 6 of them evaluated the gut microbiota of obese patients undergoing bariatric surgery and their relationship with type 2 diabetes mellitus\/glucose metabolism\/insulin resistance.  CONCLUSIONS: The intestinal microbiota is an important influencer in the regulation of the digestive tract, and obese individuals with comorbidities (diabetes mellitus, hypercholesterolemia, and metabolic syndrome) present important alterations, with an unbalance normal state, generating dysbiosis and the proliferation of bacterial species that favor the appearance of new diseases. Patients who undergo bariatric surgery present an improvement in the intestinal microbiota imbalance as well as reversibility of their comorbidities, increasing their life expectancy.<\/jats:p>","DOI":"10.1590\/0102-672020220002e1707","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T15:20:06Z","timestamp":1671636006000},"source":"Crossref","is-referenced-by-count":20,"title":["THE INTESTINAL MICROBIOME IN PATIENTS UNDERGOING BARIATRIC SURGERY: A SYSTEMATIC REVIEW"],"prefix":"10.1590","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-2703","authenticated-orcid":false,"given":"Jo\u00e3o Kleber Almeida","family":"Gentile","sequence":"first","affiliation":[{"name":"City of S\u00e3o Paulo University,  Brazil; S\u00e3o Camilo Hospital,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4956-9826","authenticated-orcid":false,"given":"Karen Danielle","family":"Oliveira","sequence":"additional","affiliation":[{"name":"S\u00e3o Camilo Hospital,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8122-1574","authenticated-orcid":false,"given":"J\u00falia Guimar\u00e3es","family":"Pereira","sequence":"additional","affiliation":[{"name":"City of S\u00e3o Paulo University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-7668","authenticated-orcid":false,"given":"Daniel Yuji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"City of S\u00e3o Paulo University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-1176","authenticated-orcid":false,"given":"Giovanna Nagatsuka","family":"Guidini","sequence":"additional","affiliation":[{"name":"City of S\u00e3o Paulo University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-8956","authenticated-orcid":false,"given":"Melissa Zanetti","family":"Cadona","sequence":"additional","affiliation":[{"name":"City of S\u00e3o Paulo University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-9625","authenticated-orcid":false,"given":"Diego Werneck","family":"Siriani-Ribeiro","sequence":"additional","affiliation":[{"name":"City of S\u00e3o Paulo University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4276-0257","authenticated-orcid":false,"given":"Mariana Tafner","family":"Perondini","sequence":"additional","affiliation":[{"name":"City of S\u00e3o Paulo University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.3390\/nu11112690","article-title":"Gut microbiota and obesity: a role for probiotics","volume":"11","author":"Abenavoli L","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s13679-018-0302-2","article-title":"Intestinal and gastric origins for diabetes resolution after bariatric surgery","volume":"7","author":"Andrew CA","year":"2018","journal-title":"Curr Obes Rep"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nrgastro.2012.161","article-title":"The importance of the gut microbiota after bariatric surgery","volume":"9","author":"Aron-Wisnewsky J","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/gutjnl-2018-316103","article-title":"Major microbiota dysbiosis in severe obesity: fate after bariatric surgery","volume":"68","author":"Aron-Wisnewsky J","year":"2019","journal-title":"Gut"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/gutjnl-2018-316815","article-title":"Severe obesity and gut microbiota: does bariatric surgery really reset the system?","volume":"68","author":"Cani PD","year":"2019","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1093\/advances\/nmy078","article-title":"Diet, gut microbiota, and obesity: links with host genetics and epigenetics and potential applications","volume":"10","author":"Cuevas-Sierra A","year":"2019","journal-title":"Adv 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experience of 15-year follow-up in a hospital in Macei\u00f3, Brazil","volume":"34","author":"Pinheiro JA","year":"2022","journal-title":"ABCD Arq Bras Cir Dig"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s40168-021-01011-2","article-title":"The association between obesity and weight loss after bariatric surgery on the vaginal microbiota","volume":"9","author":"Raglan O","year":"2021","journal-title":"Microbiome"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.soard.2019.08.551","article-title":"Gut microbiota adaptation after weight loss by Roux-en-Y gastric bypass or sleeve gastrectomy bariatric surgeries","volume":"15","author":"S\u00e1nchez-Alcoholado L","year":"2019","journal-title":"Surg Obes Relat Dis"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1099\/mic.0.000853","article-title":"Metabolic networks of the human gut 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A comprehensive review","volume":"16","author":"Talavera-Urquijo E","year":"2020","journal-title":"Surg Obes Relat Dis"},{"issue":"4","key":"ref24","first-page":"e1400","article-title":"Postoperative changes in intestinal microbiota and use of probiotics in Roux-en-Y gastric bypass and sleeve vertical gastrectomy: an integrative review","volume":"31","author":"Wagner NRF","year":"2018","journal-title":"ABCD Arq Bras Cir Dig"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1073\/pnas.0812600106","article-title":"Human gut microbiota in obesity and after gastric bypass","volume":"106","author":"Zhang H","year":"2009","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo)"],"original-title":["O MICROBIOMA INTESTINAL NOS PACIENTES SUBMETIDOS A CIRURGIA BARI\u00c1TRICA. REVIS\u00c3O SISTEM\u00c1TICA"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-67202022000100503&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T15:20:32Z","timestamp":1671636032000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-67202022000100503&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":25,"alternative-id":["S0102-67202022000100503"],"URL":"https:\/\/doi.org\/10.1590\/0102-672020220002e1707","relation":{},"ISSN":["2317-6326","0102-6720"],"issn-type":[{"value":"2317-6326","type":"electronic"},{"value":"0102-6720","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e1707"}}