{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:04:08Z","timestamp":1753887848081,"version":"3.41.2"},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT  BACKGROUND: There are lesions that are still being missed in colonoscopy. Many of those could be superficially elevated serrated lesions or depressed ones.  AIMS: The aim of this study was to compare the histopathological characteristics of these lesions and their risks for submucosal carcinoma.  METHODS: This is a retrospective, cross-sectional, and observational study comparing 217 superficially elevated serrated lesions larger than 5 mm resected by colonoscopies (G1) with 558 depressed lesions (G2).  RESULTS: In G1, 217 lesions were found in 12,653 (1.7%) colonoscopies; in G2, 558 lesions were found in 36,174 (1.5%) colonoscopies. In G1, 63.4% were women and in G2, there was no gender predominance. The average size of G1 was 16.2 mm and G2 was 9.2 mm (p&lt;0.001). G1 predominated on the proximal colon and G2 on the distal and rectum (p&lt;0.001). In G1, there were 214 (98.6%) low-grade intramucosal neoplasia and 3 (1.4%) high-grade intramucosal neoplasia. Excluding 126 hyperplastic polyps and considering 91 sessile serrated adenomas in G1, we observed 88 (96.7%) low-grade intramucosal neoplasia and 3 (3.3%) high-grade intramucosal neoplasia; in G2, we observed 417 (74.7%) low-grade intramucosal neoplasia, 113 (20.3%) high-grade intramucosal neoplasia, and 28 (5.0%) submucosal adenocarcinomas (p&lt;0.001).  CONCLUSION: Depressed lesions significantly had more high-grade intramucosal neoplasia and more invasive carcinomas in the submucosal layer than superficially elevated serrated lesions and more than superficially elevated sessile serrated adenomas.<\/jats:p>","DOI":"10.1590\/0102-672020220002e1716","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T15:03:49Z","timestamp":1673276629000},"source":"Crossref","is-referenced-by-count":0,"title":["WHICH LESIONS ARE AT HIGHER RISK OF DEVELOPING COLORECTAL CARCINOMAS: SUPERFICIALLY ELEVATED SERRATED LESIONS OR DEPRESSED LESIONS?"],"prefix":"10.1590","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-7998","authenticated-orcid":false,"given":"Artur Adolfo","family":"PARADA","sequence":"first","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2986-1053","authenticated-orcid":false,"given":"Filadelfio Euclydes","family":"VENCO","sequence":"additional","affiliation":[{"name":"Nove de Julho Hospital,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9387-2059","authenticated-orcid":false,"given":"Miguel Reynaldo","family":"VARCA-NETO","sequence":"additional","affiliation":[{"name":"Nove de Julho Hospital,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2357-503X","authenticated-orcid":false,"given":"Roberto","family":"EL IBRAHIM","sequence":"additional","affiliation":[{"name":"Nove de Julho Hospital,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9896-2176","authenticated-orcid":false,"given":"Paula Bechara","family":"POLETTI","sequence":"additional","affiliation":[{"name":"Nove de Julho Hospital,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4170-2247","authenticated-orcid":false,"given":"Helcio Pedrosa","family":"BRITO","sequence":"additional","affiliation":[{"name":"Nove de Julho Hospital,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8831-4914","authenticated-orcid":false,"given":"Heloisa de F\u00e1tima","family":"SARE","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-7071","authenticated-orcid":false,"given":"Osvaldo","family":"MALAFAIA","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie do Paran\u00e1,  Brazil; Evang\u00e9lico Mackenzie University Hospital,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.gie.2017.01.020","article-title":"Providing data for serrated polyp detection rate benchmarks: an analysis of the New Hampshire Colonoscopy Registry","volume":"85","author":"Anderson JC","year":"2017","journal-title":"Gastrointest Endosc."},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/gutjnl-2015-310456","article-title":"Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma","volume":"66","author":"Bettington M","year":"2017","journal-title":"Gut."},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"e1569","DOI":"10.1590\/0102-672020200004e1569","article-title":"Is there a clinical pathological correlation of colorectal adenocarcinoma with the immunohistochemical expression of OPN and ABCB5?","volume":"33","author":"Castoldi DF","year":"2021","journal-title":"ABCD Arq Bras Cir Dig."},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00384-015-2416-2","article-title":"The frequency of early colorectal cancer derived from sessile serrated adenoma\/polyps among 1858 serrated polyps from a single institution","volume":"31","author":"Chino A","year":"2016","journal-title":"Int J Colorectal Dis."},{"issue":"1","key":"ref5","first-page":"984","article-title":"Endoscopist factors that influence serrated polyp detection: a multicenter study","volume":"50","author":"Crockett SD","year":"2018","journal-title":"Endoscopy."},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"e1568","DOI":"10.1590\/0102-672020200004e1568","article-title":"Are stem cell maker expression and CD133 analysis relevant to differentiate colorectal cancer?","volume":"33","author":"Czeczko 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Endosc."},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.gie.2017.06.031","article-title":"A standardized imaging protocol for the endoscopic prediction of dysplasia within sessile serrated polyps (with video)","volume":"87","author":"Tate DJ","year":"2018","journal-title":"Gastrointest Endosc."}],"container-title":["ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo)"],"original-title":["QUAIS LES\u00d5ES APRESENTAM MAIOR RISCO DE EVOLU\u00c7\u00c3O PARA CARCINOMAS COLORRETAIS: AS SERRILHADAS SUPERFICIALMENTE ELEVADAS OU AS DEPRIMIDAS?"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-67202022000100346&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T15:04:14Z","timestamp":1673276654000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-67202022000100346&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":33,"alternative-id":["S0102-67202022000100346"],"URL":"https:\/\/doi.org\/10.1590\/0102-672020220002e1716","relation":{},"ISSN":["2317-6326","0102-6720"],"issn-type":[{"type":"electronic","value":"2317-6326"},{"type":"print","value":"0102-6720"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e1716"}}