{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:32:33Z","timestamp":1790188353411,"version":"4.1.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Phenytoin-induced gingival overgrowth (PIGO) is a common complication of the continuous use of medications. This paper presents a case of PIGO hindering oral function and compromising oral hygiene and aesthetics, which was treated with a combination of nonsurgical and surgical periodontal therapies. A 39-year-old male patient was referred for dental treatment with several complaints, especially upper and lower gingival overgrowth that hindered speech and swallowing. Generalized deep probing pockets and bone loss were detected. Diagnosis of gingival overgrowth associated with phenytoin and chronic periodontitis was established. The treatment plan consisted of conservative therapy with education on oral health, motivation and meticulous oral hygiene instruction in combination with scaling and root planing. During the revaluation period, a marked reduction in the clinical parameters was noted, particularly probing pocket depth reduction. Surgical therapy for removal of gingival overgrowth was also performed to achieve pocket reduction. Supportive periodontal therapy was proposed and the patient is currently under follow-up for 4 years. Management of PIGO may be obtained by the use of periodontal procedures combined with good oral hygiene and periodontal supportive care.<\/jats:p>","DOI":"10.1590\/0103-6440201300029","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T15:16:03Z","timestamp":1423322163000},"page":"39-43","source":"Crossref","is-referenced-by-count":7,"title":["Phenytoin-Induced Gingival Overgrowth Management with Periodontal Treatment"],"prefix":"10.1590","volume":"26","author":[{"given":"Bruno C\u00e9sar de Vasconcelos","family":"Gurgel","sequence":"first","affiliation":[{"name":"UFRN - Federal University of Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Roberto Batista de","family":"Morais","sequence":"additional","affiliation":[{"name":"UFRN - Federal University of Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Carlos da","family":"Rocha-Neto","sequence":"additional","affiliation":[{"name":"UFRN - Federal University of Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euler Maciel","family":"Dantas","sequence":"additional","affiliation":[{"name":"UFRN - Federal University of Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00e3o Pereira","family":"Pinto","sequence":"additional","affiliation":[{"name":"UFRN - Federal University of Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio de Lisboa Lopes","family":"Costa","sequence":"additional","affiliation":[{"name":"UFRN - Federal University of Rio Grande do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5005\/jcdp-8-6-50","article-title":"Phenobarbital-induced gingival hyperplasia","volume":"8","author":"Lafzi A,","year":"2007","journal-title":"J Contemp Dent Pract"},{"key":"ref2","article-title":"Phenytoin-induced gingival overgrowth: a review of the molecular, immune, and inflammatory features","author":"Corr\u00eaa JD","year":"2011","journal-title":"ISRN Dent"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/154411130401500305","article-title":"Connective tissue metabolism and gingival overgrowth","volume":"15","author":"Trackman PC","year":"2004","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1248\/bpb.28.1817","article-title":"Drug-induced gingival overgrowth - a review","volume":"28","author":"Kataoka M","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1902\/jop.2005.76.6.941","article-title":"Impaired degradation of matrix collagen in human gingival fibroblasts by the antiepileptic drug phenytoin","volume":"76","author":"Kato T","year":"2005","journal-title":"J Periodontol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1601-0825.2005.01175.x","article-title":"Effect of phenytoin on collagen accumulation by human gingival fibroblasts exposed to TNF-alpha in vitro","volume":"12","author":"Kato T","year":"2006","journal-title":"Oral Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1902\/jop.2001.72.7.921","article-title":"Connective tissue growth factor in drug-induced gingival overgrowth","volume":"72","author":"Uzel MI","year":"2001","journal-title":"J Periodontol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1600-051X.1996.tb00586.x","article-title":"Determinants of gingival overgrowth severity in organ transplant patients","volume":"23","author":"Thomason JM","year":"1996","journal-title":"J Clin Periodontol"},{"key":"ref9","first-page":"42","article-title":"Serum phenytoin concentration and IgG antibody title to periodontal bacteria in patients with phenytoin-induced gingival overgrowth","volume":"3","author":"Yamada H","year":"2001","journal-title":"J Int Acad Periodontol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/sj.cdd.4401850","article-title":"TLR signaling","volume":"13","author":"Kawai T","year":"2006","journal-title":"Cell Death Differ"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1034\/j.1600-051x.2000.027007506.x","article-title":"Factors influencing phenytoin-induced gingival enlargement","volume":"27","author":"Majola MP","year":"2000","journal-title":"J Clin Periodontol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1902\/jop.1999.70.6.587","article-title":"Clinical effects of periodontal therapy on the severity of cyclosporin A-induced gingival hyperplasia","volume":"70","author":"Kantarci A","year":"1999","journal-title":"J Periodontol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1902\/jop.1999.70.9.967","article-title":"Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results","volume":"70","author":"Ilgenli T","year":"1999","journal-title":"J Periodontol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1600-051X.2006.00968.x","article-title":"The efficacy of three different surgical techniques in the management of drug-induced gingival overgrowth","volume":"33","author":"Mavrogiannis M","year":"2006","journal-title":"J Clin Periodontol"},{"key":"ref15","first-page":"63","article-title":"Full-mouth disinfection as a nonsurgical treatment approach for drug-induced gingival overgrowth: a series of 11 cases","volume":"30","author":"Dannewitz B","year":"2010","journal-title":"Int J Periodontics Restorative Dent"},{"key":"ref16","first-page":"330","article-title":"Drug-induced gingival enlargement: an overview","volume":"34","author":"Moffitt ML","year":"2013","journal-title":"Compend Contin Educ Dent"},{"key":"ref17","first-page":"115","article-title":"The effect of nonsurgical periodontal treatment on the severity of drug-induced gingival overgrowth in transplant patients","volume":"45","author":"Castronovo G","year":"2014","journal-title":"Quintessence Int"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4103\/0972-124X.134567","article-title":"Treatment of drug-induced gingival overgrowth by full-mouth disinfection: A non-surgical approach","volume":"18","author":"Pundir AJ","year":"2014","journal-title":"J Indian Soc Periodontol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1600-051X.1999.tb02523.x","article-title":"The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth","volume":"26","author":"Kamali F","year":"1999","journal-title":"J CIin Periodontol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1601-5037.2007.00252.x","article-title":"Effectiveness of periodontal therapies on the treatment of different aetiological factors induced gingival overgrowth in puberty","volume":"5","author":"Kara C","year":"2007","journal-title":"Int J Dent Hyg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/0972-124X.113066","article-title":"Drug-induced gingival overgrowth: The nemesis of gingiva unravelled","volume":"17","author":"Bharti V","year":"2013","journal-title":"J Indian Soc Periodontol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1600-051X.2006.00928.x","article-title":"Heterogeneous presence of myofibroblasts in hereditary gingival fibromatosis","volume":"33","author":"Bitu CC","year":"2006","journal-title":"J Clin Periodontol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1590\/S1806-83242012005000012","article-title":"Stromal myofibroblasts in focal reactive overgrowths of the gingiva","volume":"26","author":"Damasceno LS","year":"2012","journal-title":"Braz Oral Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1902\/jop.1997.68.4.375","article-title":"Myofibroblasts in phenytoin-induced hyperplastic connective tissue in the rat and in human gingival overgrowth.","volume":"68","author":"Dill RE","year":"1997","journal-title":"J Periodontol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1600-0765.2006.00886.x","article-title":"Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor beta: role of Rhoa-Rock and c-Jun N-terminal kinase signaling pathways","volume":"41","author":"Smith PC","year":"2006","journal-title":"J Periodontal Res"}],"container-title":["Brazilian Dental Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bdj\/v26n1\/0103-6440-bdj-26-01-00039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T14:57:35Z","timestamp":1566313055000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-64402015000100039&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0103-64402015000100039"],"URL":"https:\/\/doi.org\/10.1590\/0103-6440201300029","relation":{},"ISSN":["0103-6440"],"issn-type":[{"value":"0103-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}