{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:51:27Z","timestamp":1789775487157,"version":"4.0.1"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Williams-Beuren syndrome (WBS), also known as Williams syndrome, is a rare congenital disorder involving cardiovascular problems, mental retardation, distinctive facial features and tooth anomalies. It is caused by the submicroscopic deletion of 1.5 to 1.8 Mb on chromosome 7q11.23. This paper reports the dental care to a 7-year-old child with WBS syndrome. The interview also revealed visual impairment, sensorineural hearing loss, hyperacusis, photophobia and hoarse voice. The intraoral clinical examination showed anterior open bite, tongue thrusting, excessive interdental spacing, enamel hypomineralization of the incisors, hypoplasia and caries lesions. The dental treatment included: modulating sessions to control aversion to noises, the photophobia, and the dental fear and anxiety because of his reduced visual acuity; oral hygiene instructions, dietary and daily use of a 0.05% sodium fluoride mouthwash; the permanent mandibular left first molar was treated endodontically, and maxillary and mandibular first molars were restored with amalgam. Due to the patient's heart defect, a prophylactic antibiotic regimen was prescribed prior to the dental procedures. This patient has been followed up for 4 years and this case report underscores the importance of early dental evaluation and counseling for parents of WBS patients.<\/jats:p>","DOI":"10.1590\/0103-6440201300335","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T01:17:24Z","timestamp":1437009444000},"page":"312-316","source":"Crossref","is-referenced-by-count":6,"title":["Oral Findings and Dental Treatment in a Child with Williams-Beuren Syndrome"],"prefix":"10.1590","volume":"26","author":[{"given":"Carolina Paes","family":"Torres","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleice","family":"Valadares","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Izabella","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Borsatto","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kranya Victoria","family":"D\u00edaz-Serrano","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Mussolino de","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.32607\/20758251-2014-6-1-9-22","article-title":"Williams syndrome as a model for elucidation of the pathway genes - the brain - cognitive functions: genetics and epigenetics","volume":"6","author":"Nikitina EA","year":"2014","journal-title":"Acta Naturae"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/088307380101600305","article-title":"Williams (Williams Beuren) syndrome: a distinct neurobehavioral disorder","volume":"16","author":"Kaplan P","year":"2001","journal-title":"J Child Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/088307380201700406","article-title":"Prevalence estimation of Williams syndrome","volume":"17","author":"Str\u00f8mme P","year":"2002","journal-title":"J Child Neurol"},{"key":"ref4","first-page":"262","article-title":"Williams syndrome: oral presentation of 45 cases","volume":"16","author":"Herzberg J","year":"1994","journal-title":"Pediatr Dent"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1542\/peds.107.5.1192","article-title":"American Academy of Pediatrics. 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Guideline on behavior guidance for the pediatric dental patient","volume":"33","year":"2011","journal-title":"Pediatr Dent"},{"key":"ref10","first-page":"1736","article-title":"Prevention of infective endocarditis - Guidelines from American Heart Association","volume":"116","author":"Wilson W","year":"2007","journal-title":"Circulation"},{"key":"ref11","first-page":"110","article-title":"American Academy on Pediatric Dentistry Council on Clinical Affairs: Policy on use of a caries-risk assessment tool (CAT) for infants, children, and adolescents","volume":"33","year":"2011","journal-title":"Pediatr Dent"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1002\/dvdy.21311","article-title":"TFII-I Gene family during tooth development: candidate genes for tooth anomalies in Williams Syndrome","volume":"236","author":"Ohazama A","year":"2007","journal-title":"Dev Dyn"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1754-4505.2007.tb01751.x","article-title":"Transitional implants in a patient with Williams-Beuren syndrome: a four-year follow-up","volume":"27","author":"Mass E","year":"2007","journal-title":"Spec Care Dent"},{"key":"ref14","first-page":"1","article-title":"Williams Syndrome: Ophthalmological examination and review of systemic manifestations","volume":"30","author":"Weber SL","year":"2014","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/S1807-59322007000200011","article-title":"Williams syndrome. Development of a new scoring system for clinical diagnosis","volume":"62","author":"Sugayama SMM","year":"2007","journal-title":"Clinics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/00016350310001451","article-title":"Dental characteristics in Williams syndrome: a clinical and radiographic evaluation","volume":"61","author":"Axelsson S","year":"2003","journal-title":"Acta Odontol Scand"},{"key":"ref17","first-page":"2","article-title":"Adaptive behavior in Chinese children with Williams syndrome","volume":"14","author":"Ji C","year":"2014","journal-title":"BMC Pediatr"}],"container-title":["Brazilian Dental Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bdj\/v26n3\/0103-6440-bdj-26-03-00312.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T04:40:14Z","timestamp":1652848814000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-64402015000300312&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0103-64402015000300312"],"URL":"https:\/\/doi.org\/10.1590\/0103-6440201300335","relation":{},"ISSN":["0103-6440"],"issn-type":[{"value":"0103-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}