{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:11:21Z","timestamp":1764936681499},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>The aim of this study was to evaluate the radioprotective effect of vitamin E on rat parotid glands by morphometric analysis. Sixty male rats were divided into 5 groups (n=6): control, in which animals received olive oil solution; olive oil\/irradiated, in which animals received olive oil and were irradiated with a dose of 15 Gy of gamma radiation; irradiated, in which animals were irradiated with a dose of 15 Gy gamma radiation; vitamin E, which received \u03b1-tocopherol acetate solution; vitamin E\/irradiated, which received \u03b1-tocopherol acetate solution before irradiation with a dose of 15 Gy gamma rays. Half of the animals were euthanized at 8 h, and the remaining at 30 days after irradiation. Both parotid glands were surgically removed and morphometric analysis of acinar cells was performed. Data were subjected to two-way ANOVA and Tukey's test (\u03b1=0.05). Morphometric analysis showed a significant reduction in the number of parotid acinar cells at 30 days in olive oil\/irradiated and irradiated groups. In groups evaluated over time a significant reduction was shown at 30 days in olive oil\/irradiated and irradiated groups, indicating that ionizing radiation caused tissue damage. The vitamin E\/irradiated group presented more acinar cells than the irradiated group, but no statistically significant difference was observed (p&gt;0.05). In conclusion, vitamin E seems to have failed as a radioprotective agent on acinar cells in rat parotid glands.<\/jats:p>","DOI":"10.1590\/0103-6440201301781","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T15:56:32Z","timestamp":1377532592000},"page":"183-187","source":"Crossref","is-referenced-by-count":12,"title":["Radioprotective Effect of Vitamin E in Parotid Glands: a Morphometric Analysis in Rats"],"prefix":"10.1590","volume":"24","author":[{"given":"Carolina Cintra","family":"Gomes","sequence":"first","affiliation":[{"name":"UNICAMP - University of Campinas  Piracicaba,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia Maria de Moraes","family":"Ramos-Perez","sequence":"additional","affiliation":[{"name":"UFPE - Federal University of Pernambuco,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyel Elias da Cruz","family":"Perez","sequence":"additional","affiliation":[{"name":"UFPE - Federal University of Pernambuco,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Duarte","family":"Novaes","sequence":"additional","affiliation":[{"name":"UNICAMP - University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frab Norberto","family":"Boscolo","sequence":"additional","affiliation":[{"name":"UNICAMP - University of Campinas  Piracicaba,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange Maria de","family":"Almeida","sequence":"additional","affiliation":[{"name":"UNICAMP - University of Campinas  Piracicaba,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0360-3016(03)01437-8","article-title":". Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy","volume":"58","author":"M\u00fcnter MW","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2307\/3579960","article-title":"Novel protection strategy against X-ray induced damage to salivary glands","volume":"149","author":"Nagler R","year":"1998","journal-title":"Radiat Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1067\/moe.2000.106343","article-title":"Salivary epidermal growth factor levels decrease in patients receiving radiation therapy to the head and neck","volume":"89","author":"Dumbrigue HB","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0360-3016(00)01441-3","article-title":". A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results","volume":"49","author":"Chao KSC","year":"2001","journal-title":"Int J Radiation Oncology Biol Phys"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2307\/3577641","article-title":"Peters LJ. Response of parotid organ culture to radiation","volume":"120","author":"Stephens LC","year":"1989","journal-title":"Radiat Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/00000658-199522240-00008","article-title":"Intestinal radioprotection by vitamin E (alpha-tocopherol)","volume":"222","author":"Felemovicius I","year":"1995","journal-title":"Ann Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1002\/lary.23609","article-title":". Protective effects of resveratrol on salivary gland damage induced by total body irradiation in rats","volume":"122","author":"Simsek G","year":"2012","journal-title":"Laryngoscope"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1383-5718(98)00095-3","article-title":"Antioxidant vitamins C, E and beta carotene against gamma-ray-induced DNA damage in mouse cells","volume":"417","author":"Konopacka M","year":"1998","journal-title":"Mutat Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.archoralbio.2005.06.008","article-title":"Evaluation of radioprotective effect of vitamin E in salivary dysfunction in irradiated rats","volume":"51","author":"Ramos FMMR","year":"2006","journal-title":"Arch Oral Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1383-5718(00)00133-9","article-title":"Antioxidants vitamins C, E and beta carotene reduce DNA damage before as well as after gamma-ray irradiation of human lymphocytes <italic>in vitro<\/italic>","volume":"491","author":"Konopacka M","year":"2001","journal-title":"Mutat Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1679\/aohc.61.417","article-title":"Postnatal development of the rat sublingual glands. A morphometric and radioautographic study","volume":"61","author":"Taga R","year":"1998","journal-title":"Arch Histol Cytol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1038\/sj.bjc.6602577","article-title":"Intensity-modulated radiation therapy: Emerging cancer treatment technology","volume":"92","author":"Hong TS","year":"2005","journal-title":"Br J Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF02889885","article-title":"Morphologic and histochemical studies on the differing radiosensitivity of ductular and acinar cells of the rat submandibular gland","volume":"45","author":"Abok K","year":"1984","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2307\/3579045","article-title":"The role of secretory granules in radiation-induced dysfunction of rat salivary glands","volume":"141","author":"Peter B","year":"1995","journal-title":"Radiat Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0964-1955(96)00040-1","article-title":"Ultrastructural morphometry of parotid acinar cells following fractionated irradiation","volume":"33B","author":"Grehn AL","year":"1997","journal-title":"Oral Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2334\/josnusd.52.369","article-title":"Ultrastructural assessment of the radioprotective effects of sodium selenite on parotid glands in rats","volume":"52","author":"Tuji FM","year":"2010","journal-title":"J Oral Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2307\/3579765","article-title":"Radiation-induced progressive decrease in fluid secretion in rat submandibular glands is related to decreased acinar volume and not impaired calcium signaling","volume":"151","author":"O'Connell AC","year":"1999","journal-title":"Radiat Res"},{"key":"ref18","first-page":"279","article-title":"Fractionated irradiation and early changes in salivary glands. Different effects on potassium efflux, exocytotic amylase release and gland morphology","volume":"64","author":"Franzen L","year":"1991","journal-title":"Lab Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/0959-8049(95)00400-9","article-title":"Can \u00ce\u00b1 tocopherol and \u00ce\u00b2 carotene supplementation reduce adverse radiation effects on salivary glands?","volume":"31A","author":"Funegard U","year":"1995","journal-title":"Eur J Canc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.bbrc.2010.03.103","article-title":"Vitamin E as a novel enhancer of macroautophagy in rat hepatocytes and H4-II-E cells","volume":"394","author":"Karim MR","year":"2010","journal-title":"Biochem Biophys Res Commum"}],"container-title":["Brazilian Dental Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bdj\/v24n3\/0103-6440-bdj-24-03-183.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T11:38:59Z","timestamp":1495885139000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-64402013000300183&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0103-64402013000300183"],"URL":"https:\/\/doi.org\/10.1590\/0103-6440201301781","relation":{},"ISSN":["0103-6440"],"issn-type":[{"value":"0103-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}