{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:11:28Z","timestamp":1773015088805,"version":"3.50.1"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Bisphosphonate-related osteonecrosis of the jaws (BROJ) has been described since 2003 as an adverse effect of bisphosphonate medications. These drugs act on the vasculature and bone remodeling, mainly on osteoclastic activity and can cause areas of necrotic bone exposure. Treatment for the BROJ is not yet defined, but surgical treatment is one of the forms proposed, which may cause oral deformities like sinus communication in some cases. In situations like this the buccal fat pad is an important alternative for coating nasal-oral communications, due its large blood supply, elasticity, absence of restriction by age and safety. This paper presents the case of a 58-year-old woman with BROJ in the left maxilla caused by the use of zoledronic acid for metastatic breast cancer. The extensive necrotic bone area was surgically removed resulting in oral sinus communication. A buccal fat pad was used to cover the defect. More studies should be performed regarding the treatment of BROJ but, if necessary, a buccal fat pad flap could be an alternative to solve nasal-oral communications related to BROJ.<\/jats:p>","DOI":"10.1590\/0103-6440201301918","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T21:16:45Z","timestamp":1436995005000},"page":"317-320","source":"Crossref","is-referenced-by-count":9,"title":["Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaws with the Use of Buccal Fat Pad: Case Report"],"prefix":"10.1590","volume":"26","author":[{"given":"Luiz Fernando Mathias","family":"Duarte","sequence":"first","affiliation":[{"name":"Universidade Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleber","family":"Alonso","sequence":"additional","affiliation":[{"name":"Universidade Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine Cristina","family":"Basso","sequence":"additional","affiliation":[{"name":"Universidade Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano Lauria","family":"Dib","sequence":"additional","affiliation":[{"name":"Universidade Paulista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tripleo.2006.06.004","article-title":"Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management","volume":"102","author":"Ruggiero SL","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx RE","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.joms.2003.11.009","article-title":"New foundations in understanding osteonecrosis of the jaws","volume":"62","author":"Assael LA","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joms.2008.01.026","article-title":"Inhibition of oral mucosal cell wound healing by bisphosphonates","volume":"66","author":"Landesberg R","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.oooo.2014.04.017","article-title":"Bisphosphonate-induced osteonecrosis of the jaws: clinical, imaging, and histopathology findings","volume":"118","author":"Franco-Pretto E","year":"2014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joms.2006.11.003","article-title":"Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. 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