{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:55:23Z","timestamp":1778648123472,"version":"3.51.4"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Congenital malformations and cancer may share common etiological factors and the association between nonsyndromic cleft lip and\/or palate (NSCL\/P) and cancers has been observed in different studies. The objective of this study was to evaluate the frequency of cancer in relatives of patients with NSCL\/P. This investigation was a cross-sectional, case-controlled study, evaluating 358 patients with NSCL\/P treated at a Referral Center for craniofacial deformities (case group) and 358 patients without craniofacial alterations (control group). Information concerning the gender, age and family history of cancer in first-degree relatives for both groups was obtained. The frequency of cancer was 6.4% (n=46) in the studied population, with 18 subjects in the case group (5%) and 28 (7.8%) in control. In both groups, the most frequently reported cases were those of breast, colorectal, stomach, prostate and uterus cancers, but there was no association between the two groups. There was no association with a family history of cancer among the first-degree relatives (odds ratio=0.62; 95% IC: 0.34 to 1.15), neither when the analysis was made by type of cancer. In conclusion, both epidemiological and genetic studies have suggested common etiological factors for NSCL\/P and cancer. However, in this population-based study, no association between cancer and NSCL\/P could be confirmed.<\/jats:p>","DOI":"10.1590\/0103-6440201302191","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T19:56:26Z","timestamp":1377546986000},"page":"200-203","source":"Crossref","is-referenced-by-count":8,"title":["Frequency of Cancer in First-Degree Relatives of Patients with Cleft Lip and\/or Palate in the Brazilian Population"],"prefix":"10.1590","volume":"24","author":[{"given":"Leonardo Santos","family":"Lima","sequence":"first","affiliation":[{"name":"Unimontes - State University of Montes Claros,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus de Oliveira","family":"Silverio","sequence":"additional","affiliation":[{"name":"Jose do Rosario Vellano University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Sergio Oliveira","family":"Swerts","sequence":"additional","affiliation":[{"name":"Jose do Rosario Vellano University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibele Nascimento de","family":"Aquino","sequence":"additional","affiliation":[{"name":"Unimontes - State University of Montes Claros,  Brazil; UNICAMP - University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella Reis Barbosa","family":"Martelli","sequence":"additional","affiliation":[{"name":"Unimontes - State University of Montes Claros,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hercilio","family":"Martelli-Junior","sequence":"additional","affiliation":[{"name":"Unimontes - State University of Montes Claros,  Brazil; Jose do Rosario Vellano University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.14219\/jada.archive.2009.0022","article-title":"AXIS inhibition protein 2, orofacial clefts and a family history of cancer","volume":"140","author":"Menezes R","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/S1415-790X2011000100014","article-title":"Frequency of congenital craniofacial malformations in a Brazilian Reference Center","volume":"14","author":"Parana\u00edba LM","year":"2011","journal-title":"Rev Bras Epidemiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"Mossey PA","year":"2009","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1601-0825.2009.01577.x","article-title":"The genetics of isolated orofacial clefts: from genotypes to subphenotypes","volume":"15","author":"Jugessur A","year":"2009","journal-title":"Oral Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/bdra.20732","article-title":"Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and\/or palate in the Brazilian population","volume":"88","author":"Bufalino A","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/sj.bjc.6600488","article-title":"Do parents of children with congenital malformations have a higher cancer risk? 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