{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:01:10Z","timestamp":1776128470590,"version":"3.50.1"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Extranodal natural killer (NK)\/T-cell lymphoma is an aggressive malignant tumor with distinctive clinicopathological features, characterized by vascular invasion and destruction, prominent necrosis, cytotoxic lymphocyte phenotype and a strong association with Epstein-Barr virus. Here is reported an extranodal nasal NK\/T-cell lymphoma case, involving the maxillary sinus, floor of the orbit, and interestingly extending to the oral cavity through the alveolar bone and buccal mucosa, preserving the palate, leading to a primary misdiagnosis of aggressive periodontal disease. Moreover, this work investigated for the first time the immunohistochemical expression of fatty acid synthase (FASN) and glucose transporter 1 (GLUT-1) proteins in this neoplasia. FASN showed strong cytoplasmatic expression in the neoplastic cells, whereas GLUT-1 and CD44 were negative. These findings suggest that the expression of FASN and the loss of CD44 might be involved in the pathogenesis of the extranodal nasal NK\/T-cell lymphoma, and that GLUT-1 may not participate in the survival adaptation of the tumor cells to the hypoxic environment. Further studies with larger series are required to confirm these initial results.<\/jats:p>","DOI":"10.1590\/0103-6440201302202","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T19:56:27Z","timestamp":1377546987000},"page":"284-288","source":"Crossref","is-referenced-by-count":14,"title":["Extranodal Nasal NK\/T-Cell Lymphoma: A Rare Oral Presentation and FASN, CD44 and GLUT-1 Expression"],"prefix":"10.1590","volume":"24","author":[{"given":"Helder Antonio Rebelo","family":"Pontes","sequence":"first","affiliation":[{"name":"UFPA - Federal University of Para, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia Sirotheau Correa","family":"Pontes","sequence":"additional","affiliation":[{"name":"UFPA - Federal University of Para, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunno Santos de Freitas","family":"Silva","sequence":"additional","affiliation":[{"name":"UFPA - Federal University of Para, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Paiva","family":"Fonseca","sequence":"additional","affiliation":[{"name":"UNICAMP - University of Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Augusto Benevenuto de","family":"Andrade","sequence":"additional","affiliation":[{"name":"UNICAMP - University of Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Hugo Toral","family":"Rizo","sequence":"additional","affiliation":[{"name":"UNICAMP - University of Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Jose","family":"Romanach","sequence":"additional","affiliation":[{"name":"UNICAMP - University of Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Esquiche","family":"Leon","sequence":"additional","affiliation":[{"name":"UNICAMP - University of Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oslei Paes de","family":"Almeida","sequence":"additional","affiliation":[{"name":"UNICAMP - University of Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12253-009-9183-8","article-title":". 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