{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:04:40Z","timestamp":1773903880557,"version":"3.50.1"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>The aim of this study was to evaluate, by histological analysis, the effect of growth hormone (GH) on periodontal ligament and alveolar bone during experimental tooth movement in rats. Eighty male Wistar rats divided into control (C) and experimental (E) groups were examined after 3, 7, 14 and 21 days under controlled climate conditions. Orthodontic force (30 cN) was applied on the maxillary first molar by an orthodontic appliance. Group E received 0.1 IU\/kg\/day of GH and Group C received 0.5 mL\/kg\/day of saline. The samples were processed and evaluated under optical microscopy and polarized light microscopy. The Kruskal Wallis test was applied to compare the intergroup variables at 5% significance level. Group E presented a larger number of osteoclasts on the 3rd and 7th days and Howship lacunae on the 3 rd day, a smaller number of blood vessels and greater amount of mature collagen on the 3 rd and 7 th days than Group C (p&lt;0.05). It was concluded that GH accelerated and intensified bone resorption and produced delay in immature collagen formation during experimental tooth movement.<\/jats:p>","DOI":"10.1590\/0103-6440201302286","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T14:23:44Z","timestamp":1392906224000},"page":"503-507","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Growth Hormone in Experimental Tooth Movement"],"prefix":"10.1590","volume":"24","author":[{"given":"Jucienne Salgado","family":"Ribeiro","sequence":"first","affiliation":[{"name":"PUCPR - Catholic University of Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Vinicius Bolognesi","family":"Maciel","sequence":"additional","affiliation":[{"name":"UFRJ - Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00e9gya Amorin Henriques","family":"Knop","sequence":"additional","affiliation":[{"name":"PUCPR - Catholic University of Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria \u00c2ngela Naval","family":"Machado","sequence":"additional","affiliation":[{"name":"UFPR - Federal University of Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria Trindade","family":"Gr\u00e9gio","sequence":"additional","affiliation":[{"name":"PUCPR - Catholic University of Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa Souza","family":"Camargo","sequence":"additional","affiliation":[{"name":"PUCPR - Catholic University of Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1745-7262.2008.00403.x","article-title":"Physiological and pharmacological basis for the ergogenic effects of growth hormone in elite sports","volume":"10","author":"Ehrnborg C","year":"2008","journal-title":"Asian J Androl"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1172\/JCI104479","article-title":"Studies on human growth hormone. 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