{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T02:07:24Z","timestamp":1675476444141},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Abstract The study on the efficacy of oral analgesics reported that no single class of drug is effective in post-surgical dental pain. Pain following removal of third molar is most commonly used and widely accepted acute pain model for assessing the analgesic effect of drugs in humans. Reports demonstrated that analgesic efficacy in the human dental model is highly predictive. The high incidence of false-negative findings in analgesic investigations hinders the process of molecular discovery. Molecular mechanism of post-surgical pain is not known. More importantly, the animal model for postoperative dental pain is not well established. In an attempt to discover an effective post-surgical dental pain blocker with acceptable side effects, it is essential to elucidate the molecular mechanism of post-operative dental pain. The present study investigated mandibular molars extraction in rat as an animal model for the post-operative dental pain in central nervous system. Using c-Fos immunohistochemistry, we demonstrated that pre administration of GBP (150 mg\/kg. i.p) significantly (p&lt; 0.01) neutralized the surgical molar extraction induced c-Fos expression bilaterally in rat hypothalamus. Present results indicate that pain after surgical molar extraction might follow novel neural pathways therefore difficult to treat with existing anti-nociceptive drugs.<\/jats:p>","DOI":"10.1590\/0103-6440201600207","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T22:20:11Z","timestamp":1481408411000},"page":"744-750","source":"Crossref","is-referenced-by-count":1,"title":["Gabapentin Differentially Modulate c-Fos Expression in Hypothalamus and Spinal Trigeminal Nucleus in Surgical Molar Extraction"],"prefix":"10.1590","volume":"27","author":[{"given":"Jamil Ahsan","family":"Kazi","sequence":"first","affiliation":[{"name":"Universiti Teknologi MARA,  Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ban Kahtan","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Universiti Teknologi MARA,  Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"203","article-title":"Relieving post-operative pain","volume":"28","author":"Chauvin M","year":"1999","journal-title":"Presse Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0304-3959(02)00233-6","article-title":"Experimental incision-induced pain in human skin: effects of systemic lidocaine on flare formation and hyperalgesia","volume":"100","author":"Kawamata M","year":"2002","journal-title":"Pain"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-60327-323-7_15","article-title":"The value of the dental impaction pain model in drug development","volume":"617","author":"Cooper SA","year":"2010","journal-title":"Methods Mol Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1177\/0022034513505620","article-title":"Pain fiber anesthetic reduces brainstem Fos after tooth extraction","volume":"92","author":"Badral B","year":"2013","journal-title":"J Dent Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pain.2010.02.018","article-title":"Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations","volume":"149","author":"Dworkin RH","year":"2010","journal-title":"PAIN"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0149-2918(04)90076-8","article-title":"Comparison of rofecoxib and oxycodone plus acetaminophen in the treatment of acute pain: a randomized, double-blind, placebo-controlled study in patients with moderate to severe postoperative pain in the third molar extraction model","volume":"26","author":"Korn S","year":"2004","journal-title":"Clin Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/10454411000110010401","article-title":"Acute and chronic craniofacial pain: brainstem mechanisms of nociceptive transmission and neuroplasticity, and their clinical correlates","volume":"11","author":"Sessle B. J","year":"2000","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0304-3959(95)01441-1","article-title":"Characterization of a rat model of incisional pain","volume":"64","author":"Brennan TJ","year":"1996","journal-title":"Pain"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12031-007-0048-x","article-title":"Effect of gabapentin on c-Fos expression in the CNS after paw surgery in rats","volume":"32","author":"Kazi JA","year":"2007","journal-title":"J Mol Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/00000542-200209000-00004","article-title":"Is gabapentin a \"Broad-spectrum\" analgesic?","volume":"97","author":"Gilron I","year":"2002","journal-title":"Anesthesiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1097\/00000542-200305000-00037","article-title":"Gabapentin blocks and reverses antinociceptive morphine tolerance in the rat paw-pressure and tail-flick tests","volume":"98","author":"Gilron I","year":"2003","journal-title":"Anesthesiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/00000542-200209000-00007","article-title":"A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy","volume":"97","author":"Dirks J","year":"2002","journal-title":"Anesthesiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/BF03018484","article-title":"Preemptive gabapentin decreases postoperative pain after lumbar discoidectomy","volume":"51","author":"Pandey CK","year":"2004","journal-title":"Can J Anesth"},{"key":"ref14","article-title":"Spinal- supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin","author":"Suzuki 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