{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:36:16Z","timestamp":1788212176118,"version":"build-2803163510"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Abstract Subjects susceptible to chronic periodontitis (CP) show a high risk for the development of peiimplantitis (PI). Both diseases are multifactorial, presenting similarities in their pathophysiology and polygenic profile. MMP-13 (matrix metalloproteinases 13\/ collagenase 3) is a collagenolytic enzyme, which expression is induced by TGF beta 3 (transforming growth factor type 3) in human gingival fibroblasts and inhibited by TIMP-2 (tissue inhibitor of metalloproteinase type 2). The aim of this study was to investigate the occurrence of peiimplantitis (PI) in subjects with history of chronic periodontitis (CP) and polymorphisms frequency in MMP13, TIMP2 and TGFB3 genes. One hundred and sixty-three volunteers received dental implant placement were submitted to oral and radiographic examination in order to identify past history of CP or presence of PI. Volunteers were divided into 4 groups: Control (without PI and CP, n=72), CP (with CP and without PI, n=28), PI (with PI and without CP, n=28) and diseased (with CP and PI, n=35). The chi-square test correlated genotypes in specific regions of MMP13 (rs2252070), TIMP2 (rs7501477) and TGFB3 (rs2268626) genes, considering the interaction between CP and PI. The results showed that volunteers with CP had 3.2 times more susceptibility to develop PI (p=0.0004) compared to those without CP. No significant association was observed in MMP13, TIMP2 and TGFB3 genes with CP or PI. CP is a risk factor to develop PI, however, there is no association of both diseases with polymorphisms in the MMP13, TIMP2 and TGFB3 genes.<\/jats:p>","DOI":"10.1590\/0103-6440201600601","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T17:50:31Z","timestamp":1459619431000},"page":"128-134","source":"Crossref","is-referenced-by-count":12,"title":["MMP13, TIMP2 and TGFB3 Gene Polymorphisms in Brazilian Chronic Periodontitis and Periimplantitis Subjects"],"prefix":"10.1590","volume":"27","author":[{"given":"Roberto","family":"Gon\u00e7alves Junior","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristides da Rosa","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil; Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Jorge","family":"Schoichet","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Henrique Ramirez","family":"Nunes","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rackel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Ladeira","family":"Bonato","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valquiria","family":"Quinelato","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Santos","family":"Antunes","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Calvano","family":"K\u00fcchler","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lobo","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo de Mello","family":"Villas-B\u00f4as","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Rezende","family":"Vieira","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, USA; University of Pittsburgh, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mauro","family":"Granjeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil; National Institute of Metrology, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Ladeira","family":"Casado","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil; Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-051X.2008.01283.x","article-title":"Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology","volume":"35","author":"Lindhe J","year":"2008","journal-title":"J Clin Periodontol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1590\/0103-6440201302006","article-title":"History of chronic periodontitis is a high risk factor for peri-implant disease","volume":"24","author":"Casado 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