{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:03:36Z","timestamp":1792825416901,"version":"4.5.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Abstract Inferior alveolar nerve block has a high failure rate in the treatment of mandibular posterior teeth with irreversible pulpitis. The aim of this study was to compare the anesthetic efficacy of 4% articaine, 2% lidocaine and 2% mepivacaine, all in combination with 1:100,000 epinephrine, in patients with irreversible pulpitis of permanent mandibular molars during a pulpectomy procedure. Sixty-six volunteers from the Emergency Center of the School of Dentistry, University of S\u00e3o Paulo, randomly received 3.6 mL of local anesthetic as a conventional inferior alveolar nerve block (IANB). The subjective signal of lip numbness, pulpal anesthesia and absence of pain during the pulpectomy procedure were evaluated respectively, by questioning the patient, stimulation using an electric pulp tester and a verbal analogue scale. All patients reported the subjective signal of lip numbness. Regarding pulpal anesthesia success as measured with the pulp tester, the success rate was respectively 68.2% for mepivacaine, 63.6% for articaine and 63.6% for lidocaine. Regarding patients who reported no pain or mild pain during the pulpectomy, the success rate was, respectively 72.7% for mepivacaine, 63.6% for articaine and 54.5% for lidocaine. These differences were not statistically significant. Neither of the solutions resulted in 100% anesthetic success in patients with irreversible pulpitis of mandibular molars.<\/jats:p>","DOI":"10.1590\/0103-6440201600663","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T21:49:00Z","timestamp":1474148940000},"page":"381-386","source":"Crossref","is-referenced-by-count":31,"title":["Anesthetic Efficacy in Irreversible Pulpitis: A Randomized Clinical Trial"],"prefix":"10.1590","volume":"27","author":[{"given":"Carlos E.","family":"Allegretti","sequence":"first","affiliation":[{"name":"Universidade Paulista, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta M.","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C. R. T.","family":"Horliana","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paschoal L.","family":"Armonia","sequence":"additional","affiliation":[{"name":"Universidade Paulista, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney G.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Peixoto","family":"Tortamano","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0099-2399(06)81366-X","article-title":"Endodontic anesthesia in mandibular molars: a clinical study","volume":"19","author":"Cohen HP","year":"1993","journal-title":"J Endod"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/01.DON.0000125317.21892.8F","article-title":"Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis","volume":"30","author":"Claffey E","year":"2004","journal-title":"J Endod"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.joen.2009.04.012","article-title":"Anesthetic efficacy of supplemental buccal and lingual infiltrations of articaine and lidocaine following an inferior alveolar nerve block in patients with irreversible pulpitis","volume":"35","author":"Aggarwal V","year":"2009","journal-title":"J Endod"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.joen.2013.12.022","article-title":"Efficacy of articaine versus lidocaine as a supplemental buccal infiltration in mandibular molars with irreversible pulpitis: A prospective, randomized, double-blind study","volume":"40","author":"Rogers BS","year":"2014","journal-title":"J Endod"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.joen.2008.10.020","article-title":"A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis.","volume":"35","author":"Tortamano IP","year":"2009","journal-title":"J Endod"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.joen.2012.01.008","article-title":"Comparison of the anesthetic efficacy between bupivacaine and lidocaine in patients with irreversible pulpitis of mandibular molar","volume":"38","author":"Sampaio RM","year":"2012","journal-title":"J Endod"},{"key":"ref7","series-title":"Handbook of Local Anesthesia","author":"Malamed SF","year":"2004","edition":"5th ed."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.14219\/jada.archive.2001.0152","article-title":"Articaine hydrochloride: a study of the safety of a new amide local anesthetic","volume":"132","author":"Malamed SF","year":"2001","journal-title":"J Am Dent Assoc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.joen.2015.07.001","article-title":"Does articaine provide an advantage over lidocaine in patients with symptomatic irreversible pulpitis? A systematic review and meta-analysis","volume":"41","author":"Kung J","year":"2015","journal-title":"J Endod"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/idj.12087","article-title":"Efficacy and safety of mepivacaine compared with lidocaine in local anaesthesia in dentistry: a meta-analysis of randomised controlled trials","volume":"64","author":"Su N","year":"2014","journal-title":"Int Dent J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.2471\/BLT.08.050955","article-title":"The Declaration of Helsinki and public health","volume":"86","author":"William JR","year":"2008","journal-title":"Bull Word Health Organ"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.joen.2010.05.012","article-title":"Prospective, randomized singled-blind study of the anesthetic efficacy of 1,8 and 3,6 milliliters of 2% lidocaine with 1:50,000 epinephrine for inferior alveolar nerve block","volume":"36","author":"Wali M","year":"2010","journal-title":"J Endod"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0099-2399(87)80097-3","article-title":"An evaluation of an electric pulp tester as a measure of analgesia in human vital teeth","volume":"13","author":"Dreven LJ","year":"1987","journal-title":"J Endod"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.joen.2012.12.040","article-title":"Is mandibular molar buccal infiltration a mental and incisive nerve block? A randomized controlled trial","volume":"39","author":"Currie CC","year":"2013","journal-title":"J Endod"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.joen.2012.11.039","article-title":"Anesthetic efficacy of a primary articaine infiltration and a repeat articaine infiltration in the incisive\/mental nerve region of mandibular premolars: a prospective, randomized single-blind study","volume":"39","author":"Dressman A S","year":"2013","journal-title":"J Endod"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.joen.2011.12.006","article-title":"A prospective randomized trial of different supplementary local anesthetic techniques after failure of inferior alveolar nerve block in patients with irreversible pulpitis in mandibular teeth","volume":"38","author":"Kanaa MD","year":"2012","journal-title":"J Endod"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/154405910608500209","article-title":"Articaine is more effective than lidocaine or mepivacaine in rat sensory nerve conduction block in vitro","volume":"85","author":"Potocnik I","year":"2006","journal-title":"J Dent Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0011-8532(22)02228-5","article-title":"Local anesthetics in dental practice","volume":"28","author":"Milam SB","year":"1984","journal-title":"Dent Clin North Am"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1034\/j.1601-1546.2002.10103.x","article-title":"Local anesthetic failure in endodontics","volume":"1","author":"Hargreaves KM","year":"2002","journal-title":"Endod Topics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1177\/00220345010800060801","article-title":"Vanilloid receptor expression and capsaicin excitation of rat dental primary afferent neurons","volume":"80","author":"Chaudhary P","year":"2002","journal-title":"J Dent Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0007-117X(77)90008-7","article-title":"Variations in the normal anatomy of the inferior dental (mandibular) canal: a retrospective study of panoramic radiographs from 3612 routine dental patients","volume":"15","author":"Nortj\u00e9 CJ","year":"1977","journal-title":"Br J Oral Surg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0278-2391(83)90076-9","article-title":"Bifid mandibular nerve as a possible cause of inadequate anesthesia in the mandible","volume":"41","author":"Grover PS","year":"1983","journal-title":"J Oral and Maxillofac Surg"},{"key":"ref23","first-page":"E510","article-title":"Failure of locoregional anesthesia in dental practice. Review of the literature","volume":"11","author":"L\u00f3pez AB","year":"2006","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"836","DOI":"10.14219\/jada.archive.2010.0281","article-title":"Occurrence of paresthesia after dental local anesthetic administration in the United States","volume":"141","author":"Garisto GA","year":"2010","journal-title":"J Am Dent Assoc"},{"key":"ref25","first-page":"627","article-title":"Incidence of local anesthetic-induced neuropathies in Ontario from 1994 -1998","volume":"79","author":"Miller PA","year":"2000","journal-title":"J Dent Res"}],"container-title":["Brazilian Dental Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bdj\/v27n4\/1806-4760-bdj-27-04-00381.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T18:36:45Z","timestamp":1657305405000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-64402016000400381&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0103-64402016000400381"],"URL":"https:\/\/doi.org\/10.1590\/0103-6440201600663","relation":{},"ISSN":["0103-6440"],"issn-type":[{"value":"0103-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}