{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:17:37Z","timestamp":1787023057891,"version":"build-2736575974"},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Abstract Adenosquamous carcinoma is an aggressive variant of squamous cell carcinoma. This report describes a case of adenosquamous carcinoma with clinical features of a benign lesion and discusses the differential diagnoses, especially regarding histopathological and immunohistochemical analyses. A 45-year-old male was referred to our outpatient clinic complaining about a rapid-growing enlargement in hard palate. Clinical examination revealed an erythematous and pedunculated nodule with lobulated non-ulcerated surface. Excisional biopsy was performed following clinical diagnosis of pyogenic granuloma. Histologically, the specimen consisted of areas characterizing both well-differentiated squamous cell carcinoma and true adenocarcinoma. After a broad list of immunohistochemical markers was evaluated (AE1\/AE3, CEA, CK5, CK7, CK8\/18, p53, p63 and Ki67), the diagnosis of adenosquamous carcinoma was rendered and the patient referred to complementary surgery. Adenosquamous carcinoma represents a challenge in diagnostic routine due to its rarity, diverse range of clinical presentations and histological features. Furthermore, classical clinical benign features may be present in malignant lesions; hence the submission of every surgical specimen to histological analysis is mandatory to provide the patient the adequate treatment.<\/jats:p>","DOI":"10.1590\/0103-6440201600957","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T17:19:01Z","timestamp":1481390341000},"page":"781-786","source":"Crossref","is-referenced-by-count":5,"title":["Oral Adenosquamous Carcinoma Mimicking a Pyogenic Granuloma: a Challenging Diagnosis"],"prefix":"10.1590","volume":"27","author":[{"given":"Celina Faig","family":"Lima","sequence":"first","affiliation":[{"name":"University Braz Cubas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Acay","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lia","family":"Anbinder","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janete Dias","family":"Almeida","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin Rodarte","family":"Carvalho","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"129","article-title":"Pathology and genetics of head and neck tumours, World Health Organization Classification of Tumours","author":"Cardesa A","year":"2005","journal-title":"Lyon (France):IARC Press"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.oooo.2013.05.003","article-title":"Adenosquamous carcinoma of the head and neck: report of 20 cases and review of 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