{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:10:49Z","timestamp":1777421449838,"version":"3.51.4"},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Abstract This study evaluated the interaction between tooth movement and two anabolic androgenic steroids (AAS), Deposteron\u00ae and Nebido\u00ae. One hundred Wistar rats were divided into 3 groups: control (C) n=30, Nebido experimental (N) n=35 and Deposteron experimental (D) n=35. The control group was subdivided into 6 subgroups: 1, 2, 3, 5, 7 and 14. The experimental groups were subdivided into 7 subgroups: 0, 1, 2, 3, 5, 7 and 14, which corresponded to the day of animal\u2019s euthanasia after applying orthodontic force. Orthodontic devices were used to induce tooth movement using 50 cN of reciprocal force between the maxillary right first molar and the maxillary incisors. After euthanasia, the tissues were processed and stained with hematoxylin and eosin (HE) and tartrate-resistant acid phosphatase (TRAP). Osteoclasts, Howship\u2019s lacunae and blood vessels were quantified. Groups N and D showed acceleration in the reorganization of the periodontal ligament compared to group C. The peak of the histological events occurred in group C on day 5 and in groups N and D on day 3 after installation of the orthodontic device. There was a statistically significant difference in the number of osteoclasts (p&lt;0.05) between groups N3 and C3, and between groups N3 and D3. Supra-physiological doses of the AAS Nebido\u00ae and Deposteron\u00ae altered the number of osteoclasts, Howship\u2019s lacunae and blood vessels, accelerating the reorganization of the periodontal ligament, resulting in accelerated biological effects from the induced tooth movement in rats.<\/jats:p>","DOI":"10.1590\/0103-6440201601119","type":"journal-article","created":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T22:43:23Z","timestamp":1510440203000},"page":"504-510","source":"Crossref","is-referenced-by-count":6,"title":["Interaction of Anabolic Androgenic Steroids and Induced Tooth Movement in Rats"],"prefix":"10.1590","volume":"28","author":[{"given":"Lilian Mary","family":"Karakida","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano Miranda de","family":"Araujo","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Cristina Batista Rodrigues","family":"Johann","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa Souza","family":"Camargo","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando Motohiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odilon Guariza","family":"Guariza Filho","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0030-5898(20)32008-3","article-title":"Performance-enhancing drugs","volume":"26","author":"Ghaphery NA","year":"1995","journal-title":"Orthop Clin North Am"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1542\/peds.101.5.e6","article-title":"Anabolic steroid use by male and female middle school students","volume":"101","author":"Faigenbaum AD","year":"1998","journal-title":"Pediatrics"},{"key":"ref3","first-page":"327","article-title":"Use of anabolic-androgenic steroids among body builders in major gym centers in S\u00e3o Paulo","volume":"39","author":"Silva L.S.M. MRLM","year":"2003","journal-title":"Rev. Bras. Cienc. Farm"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1519\/JSC.0b013e318218daf0","article-title":"Higher muscle mass but lower gynoid fat mass in athletes using anabolic androgenic steroids","volume":"26","author":"Nordstrom A","year":"2012","journal-title":"J Strength Cond Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000333037","article-title":"Anabolic androgenic steroids in the general population: user characteristics and associations with substance use","volume":"18","author":"Hakansson A","year":"2012","journal-title":"Eur Addict Res"},{"key":"ref6","first-page":"289","article-title":"Anabolic steroids and craniofacial growth in the rat","volume":"63","author":"Barrett RL","year":"1993","journal-title":"Angle Orthod"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jmor.1052200104","article-title":"Effects of the anabolic steroid nandrolone phenylpropionate on craniofacial growth in rats","volume":"220","author":"Noda K","year":"1994","journal-title":"J Morphol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1067\/mod.2003.88","article-title":"The effect of anabolic steroids on mandibular growth","volume":"123","author":"Gebhardt A","year":"2003","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1001\/jama.1996.03540030065034","article-title":"Performance-enhancing drugs, fair competition, and Olympic sport","volume":"276","author":"Catlin DH","year":"1996","journal-title":"JAMA"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1249\/01.mss.0000210194.56834.5d","article-title":"Anabolic androgenic steroids: a survey of 500 users","volume":"38","author":"Parkinson AB","year":"2006","journal-title":"Med Sci Sports Exerc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"E154","DOI":"10.1152\/ajpendo.00502.2001","article-title":"Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy","volume":"283","author":"Sinha-Hikim I","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"E1172","DOI":"10.1152\/ajpendo.2001.281.6.E1172","article-title":"Testosterone dose-response relationships in healthy young men","volume":"281","author":"Bhasin S","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/clinchem\/43.7.1289","article-title":"Endocrine aspects of anabolic steroids","volume":"43","author":"Wu FC","year":"1997","journal-title":"Clin Chem"},{"key":"ref14","first-page":"143","article-title":"Experimental tooth movement in murines: study period and direction of microscopic sections","volume":"14","author":"Fracalossi ACC SJM","year":"2009","journal-title":"Rev. Dent. Press Ortodon. Ortop. Facial"},{"key":"ref15","first-page":"1417","article-title":"&{Abuse of anabolic steroids and its impact on thyroid function&}","volume":"51","author":"Fortunato RS","year":"2007","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2334\/josnusd1959.12.57","article-title":"Pharmacological effect of nandrolone phenylpropionate on the healing of dental extraction wounds: a histological investigation in rats","volume":"12","author":"dos Santos-Pinto R","year":"1970","journal-title":"J Nihon Univ Sch Dent"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1046\/j.1523-1747.1998.00431.x","article-title":"Stimulation of collagen synthesis by the anabolic steroid stanozolol","volume":"111","author":"Falanga V","year":"1998","journal-title":"J Invest Dermatol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0002-9416(79)90272-0","article-title":"Effect of metabolic alteration of periodontal fibers on orthodontic tooth movement. An experimental study","volume":"75","author":"Heller IJ","year":"1979","journal-title":"Am J Orthod"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/00220345540330021301","article-title":"The influence of injury to the periodontal membrane on the spread of gingival inflammation","volume":"33","author":"Macapanpan LC","year":"1954","journal-title":"J Dent Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1210\/jcem.83.2.4594","article-title":"Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee","volume":"83","author":"Carroll PV","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1054\/ghir.2001.0263","article-title":"Growth hormone replacement therapy for adults: into the new millennium","volume":"12","author":"Simpson H","year":"2002","journal-title":"Growth Horm IGF Res"}],"container-title":["Brazilian Dental Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bdj\/v28n4\/1806-4760-bdj-28-04-504.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T03:08:21Z","timestamp":1659841701000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-64402017000400504&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0103-64402017000400504"],"URL":"https:\/\/doi.org\/10.1590\/0103-6440201601119","relation":{},"ISSN":["0103-6440"],"issn-type":[{"value":"0103-6440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}