{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T18:58:35Z","timestamp":1725735515545},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Abstract Periapical actinomycosis caused by a gram-positive anaerobic pathogen characterizes a typical extra-radicular infection. This study determined the frequency and correlated the content of bacteria colonies with the of periapical actinomycosis size. The study comprised a total of 218 periapical lesions (PL) (cysts, granulomas or abscess). The specimens embedded in paraffin were sliced into 4-\u00b5m sections and stained with hematoxylin-eosin, Gram, Periodic Acid-Schiff (PAS) and Grocott\u2019s stain. The presence of bacterial colonies composed of filamentous structures labeled with the histochemical stains were described as Actinomyces, and for each case, the bacterial colonies were counted and measured. The correlation between the number and size of bacterial colonies and the size of PL was tested using Pearson\u2019s adjusted correlation coefficient. From 218 PL, bacterial colonies were identified in 64 biopsies. Seven cases (0.3%) fulfill the criteria for diagnosis of periapical actinomycosis. All of cases were therapy-resistant and did not showed periapical repair after 12 months of follow-up. Periapical surgery or dental extraction was performed. The correlation test indicated no correlation between the number of bacterial colonies and the lesion size (p=0.752, r=-0.148). However, a larger bacterial colony size generally resulted in a larger periapical lesion (P=0.000, r=0.657). The frequency of periapical actinomycosis was low, and this lesion should be included in the differential diagnosis of PL. The size of the Actinomyces colonies seemed to contribute to increase the size of the periapical lesion.<\/jats:p>","DOI":"10.1590\/0103-6440201701449","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T22:30:25Z","timestamp":1512253825000},"page":"688-693","source":"Crossref","is-referenced-by-count":8,"title":["Actinomycosis is not Frequent in the Periapex But is a Persistent Lesion"],"prefix":"10.1590","volume":"28","author":[{"given":"Lucas Senhorinho","family":"Esteves","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1guida Cristina Gomes","family":"Henriques","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina \u00c1vila Varginha de Moraes e","family":"Silva","sequence":"additional","affiliation":[{"name":"Private Clinic,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina Teixeira","family":"Cangussu","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Ant\u00f4nio Gon\u00e7alves","family":"Ramos","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Estrela","sequence":"additional","affiliation":[{"name":"Universidade Federal University de Goi\u00e1s,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Nunes dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"340-9","key":"ref1","first-page":"34","article-title":"The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats","volume":"20","author":"Kakehashi S","year":"1965","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1601-1546.2003.00052.x","article-title":"Non-microbial etiology: foreign body reaction maintaining post-treatment apical periodontitis","volume":"6","author":"Nair PNR","year":"2003","journal-title":"Endod Topics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0099-2399(07)80201-9","article-title":"Intraradicular bacteria and fungi in rootfilled, asymptomatic human teeth with therapy-resistant periapical lesions: a long-term light and electron microscopic follow-up study","volume":"16","author":"Nair PNR","year":"1990","journal-title":"J Endod"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0099-2399(07)80202-0","article-title":"Therapy resistant foreign body giant cell granuloma at the periapex of a root-filled human tooth","volume":"16","author":"Nair PNR","year":"1990","journal-title":"J Endod"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/iej.12220","article-title":"Keratocyst odontogenic tumour arising as a periapical lesion","volume":"47","author":"Santos JN","year":"2014","journal-title":"Int Endod J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0030-4220(78)90443-7","article-title":"Periapical actinomycosis","volume":"46","author":"Oppenheimer S","year":"1978","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0099-2399(80)80021-5","article-title":"Isolation of Actinomyces israelii from periapical lesion","volume":"6","author":"Sundqvist G","year":"1980","journal-title":"J Endod"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0099-2399(84)80102-8","article-title":"Periapical actinomycosis","volume":"10","author":"Nair PNR","year":"1984","journal-title":"J Endod"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1067\/moe.2003.87","article-title":"Periapical actinomycosis: A clinicopathologic study","volume":"95","author":"Hirshberg A","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e627","DOI":"10.4317\/medoral.19124","article-title":"Treatment of cervicofacial Actinomycosis: a report of 19 cases and review of literature","volume":"18","author":"Moghimi M","year":"2013","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijid.2007.10.006","article-title":"Actinomycosis: a great pretender. Case reports of unusual presentations and a review of the literature","volume":"12","author":"Acevedo F","year":"2008","journal-title":"Int J Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s10096-014-2165-0","article-title":"The contribution of histopathological examination to the diagnosis of cervico-facial actinomycosis: a retrospective analysis of 68 cases","volume":"33","author":"Lo ,Muzio L","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11908-005-0030-0","article-title":"Cervicofacial actinomycosis: diagnosis and management","volume":"7","author":"Oostman O","year":"2005","journal-title":"Curr Infect Dis Rep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1054\/bjom.1997.0373","article-title":"Actinomycotic ulcer of the oral mucosa: an unusual presentation of oral actinomycosis","volume":"38","author":"Alamillos-Granados FJ","year":"2000","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.tripleo.2009.06.019","article-title":"The clinical spectrum of Actinomyces-associated lesions of the oral mucosa and jawbones: correlations with histomorphometric analysis","volume":"108","author":"Kaplan I","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0278-2391(95)90176-0","article-title":"Actinomycosis presenting as a midline palatal defect","volume":"53","author":"Rubin MM","year":"1995","journal-title":"J Oral Maxillofac Surg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/(SICI)1097-0347(199905)21:3<264::AID-HED12>3.0.CO;2-Y","article-title":"Atypical presentations of actinomycosis","volume":"21","author":"Belmont MJ","year":"1999","journal-title":"Head Neck"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-9657.1986.tb00145.x","article-title":"Periapical actinomycosis: a follow-up study of 16 surgically treated cases","volume":"2","author":"Happonen RP","year":"1986","journal-title":"Endod Dent Traumatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00004770-200204000-00011","article-title":"Microbiota of periapical lesions refractory to endodontic therapy","volume":"28","author":"Sunde PT","year":"2002","journal-title":"J Endod"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2591.2006.01099.x","article-title":"On the causes of persistent apical periodontitis: a review","volume":"39","author":"Nair PNR","year":"2006","journal-title":"Int Endod J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.joen.2008.06.002","article-title":"Apical actinomycosis as a continuum of intraradicular and extraradicular infection: case report and critical review on its involvement with treatment failure","volume":"34","author":"Ricucci D","year":"2008","journal-title":"J Endod"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.joen.2008.08.013","article-title":"A new periapical index based on cone beam computed tomography","volume":"34","author":"Estrela C","year":"2008","journal-title":"J Endod"},{"key":"ref23","first-page":"301","article-title":"Radiographic evaluation of periapical lesions with and without biopsy-proven actinomyces: a pilot study","volume":"42","author":"Kukiani RM","year":"2011","journal-title":"Quintessence Int"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1590\/S0103-64402011000600002","article-title":"Histopathological study of radicular cysts diagnosed in a Brazilian population","volume":"22","author":"Santos LCS","year":"2011","journal-title":"Braz Dent J"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2012-006218","article-title":"Periapical actinomycosis","author":"Pasupathy SP","year":"2012","journal-title":"BMJ Case Reports"}],"container-title":["Brazilian Dental Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bdj\/v28n6\/1806-4760-bdj-28-06-688.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T22:01:47Z","timestamp":1514671307000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-64402017000600688&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0103-64402017000600688"],"URL":"https:\/\/doi.org\/10.1590\/0103-6440201701449","relation":{},"ISSN":["1806-4760","0103-6440"],"issn-type":[{"value":"1806-4760","type":"electronic"},{"value":"0103-6440","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}