{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:26:26Z","timestamp":1771878386936,"version":"3.50.1"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract Bleaching gel containing hydrogen peroxide (H2O2) cause damages in pulp tissue. This study investigated the action of a topical anti-inflammatory, the Otosporin\u00ae, in rats\u2019 bleached teeth with the null hypothesis of which the Otosporin\u00ae is no able to minimize the pulp inflammation that bleaching gel generates. The rat\u2019s molars were divided into groups: BLE: bleached (35% H2O2 concentration \/single application of 30 min); BLE-O: bleached followed by Otosporin\u00ae (10 min); and control: placebo gel. In the second day after dental bleaching, the rats were killed, and the jaws were processed for hematoxylin-eosin and immunohistochemistry analysis for tumor necrosis factor alpha (TNF-\u03b1), interleukin (IL)-6 and IL-17. The data collected were subjected to Kruskal-Wallis and Dunn statistical tests with at a 5% level of significance (p&lt;0.05). The BLE group had moderate to strong inflammation in the occlusal third of the coronary pulp, with necrotic areas; and BLE-O, mild inflammation (p&lt;0.05). There was a significant difference in the occlusal and middle thirds of the coronary pulp between the BLE with BLE-O and control groups (p&lt;0.05). There was no difference in the cervical third (p&gt;0.05). The BLE group had a high immunoexpression of TNF-\u03b1 than BLE-O and control groups (p&lt;0.05), with moderate and mild immunoexpression, respectively. Regarding IL-6 and IL-17, the BLE group had higher immunoexpression than control (p&lt;0.05); the BLE-O was similar to the control (p&gt;0.05). The topical anti-inflammatory Otosporin\u00ae can reduce pulp inflammation after dental bleaching in the rat teeth.<\/jats:p>","DOI":"10.1590\/0103-6440201802177","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T11:37:02Z","timestamp":1543923422000},"page":"555-561","source":"Crossref","is-referenced-by-count":24,"title":["In Vivo Study of the Action of a Topical Anti-Inflammatory Drug In Rat Teeth Submitted To Dental Bleaching"],"prefix":"10.1590","volume":"29","author":[{"given":"Francine","family":"Benetti","sequence":"first","affiliation":[{"name":"UNESP - Universidade Estadual Paulista,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Luiz Fraga","family":"Briso","sequence":"additional","affiliation":[{"name":"UNESP - Universidade Estadual Paulista,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Louzada","family":"Ferreira","sequence":"additional","affiliation":[{"name":"UNESP - Universidade Estadual Paulista,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Carminatti","sequence":"additional","affiliation":[{"name":"UNESP - Universidade Estadual Paulista,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"\u00c1lamo","sequence":"additional","affiliation":[{"name":"UNESP - Universidade Estadual Paulista,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edilson","family":"Ervolino","sequence":"additional","affiliation":[{"name":"UNESP - Universidade Estadual Paulista,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloi","family":"Dezan-J\u00fanior","sequence":"additional","affiliation":[{"name":"UNESP - Universidade Estadual Paulista,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano Tavares 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