{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:41:19Z","timestamp":1790044879996,"version":"4.0.1"},"reference-count":202,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract The aim of presented systematic scoping review was to investigate the actual and future clinical possibilities of regenerative therapies and their ability to regenerate bone, periodontal and pulp with histological confirmation of the nature of formed tissue. Electronic search was conducted using a combination between Keywords and MeSH terms in PubMed, Scopus, ISI-Web of Science and Cochrane library databases up to January 2016. Two reviewers conducted independently the papers judgment. Screened studies were read following the predetermined inclusion criteria. The included studies were evaluated in accordance with Arksey and O\u2019Malley\u2019s modified framework. From 1349 papers, 168 completed inclusion criteria. Several characterized and uncharacterized cells used in Cell Therapy have provided bone regeneration, demonstrating bone gain in quantity and quality, even as accelerators for bone and periodontal regeneration. Synthetic and natural scaffolds presented good cell maintenance, however polyglycolid-polylactid presented faster resorption and consequently poor bone gain. The Growth Factor-Mediated Therapy was able to regenerate bone and all features of a periodontal tissue in bone defects. Teeth submitted to Revascularization presented an increase of length and width of root canal. However, formed tissues not seem able to deposit dentin, characterizing a repaired tissue. Both PRP and PRF presented benefits when applied in regenerative therapies as natural scaffolds. Therefore, most studies that applied regenerative therapies have provided promising results being possible to regenerate bone and periodontal tissue with histological confirmation. However, pulp regeneration was not reported. These results should be interpreted with caution due to the short follow-up periods.<\/jats:p>","DOI":"10.1590\/0103-6440201902053","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T21:43:11Z","timestamp":1555018991000},"page":"77-95","source":"Crossref","is-referenced-by-count":21,"title":["Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review"],"prefix":"10.1590","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0361","authenticated-orcid":false,"given":"Luiz Alexandre","family":"Chisini","sequence":"first","affiliation":[{"name":"Universidade Federal de Pelotas, Brazil; Universidade do Vale do Taquari, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-3305","authenticated-orcid":false,"given":"Marcus Cristian Muniz","family":"Conde","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Taquari, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Grazioli","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Taquari, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-774X","authenticated-orcid":false,"given":"Alissa Schmidt San","family":"Martin","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Taquari, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2644-5820","authenticated-orcid":false,"given":"Rodrigo Varella de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Faculdade Meridional, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Regina Morello","family":"Sartori","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio Fernando","family":"Demarco","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.8493529","article-title":"Tissue engineering","volume":"260","author":"Langer R","year":"1993","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"Gronthos S","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1073\/pnas.0937635100","article-title":"SHED: stem cells from human exfoliated deciduous teeth","volume":"100","author":"Miura M","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo BM","year":"2004","journal-title":"Lancet"},{"key":"ref5","first-page":"130","article-title":"Isolation and characterization of dental follicle precursor cells (DFPCs)","volume":"2","author":"Vollner F","year":"2007","journal-title":"J Stem Cells Regen Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.5966\/sctm.2012-0136","article-title":"Three years after transplants in human mandibles, histological and in-line holotomography revealed that stem cells regenerated a compact rather than a spongy bone: biological and clinical implications","volume":"2","author":"Giuliani A","year":"2013","journal-title":"Stem Cells Transl Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/S0103-64402011000100001","article-title":"Dental pulp tissue engineering","volume":"22","author":"Demarco FF","year":"2011","journal-title":"Braz Dent J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1590\/0103-6440201600980","article-title":"Does cryopreservation affect the biological properties of stem cells from dental tissues?","volume":"27","author":"Conde MC","year":"2016","journal-title":"a systematic review. 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