{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:51:33Z","timestamp":1793868693804,"version":"4.6.1"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract Chronic periodontitis (CP) and Diabetes mellitus type 2 (DMII) are chronic diseases usually treated by conventional practices. On the other hand, homeopathy can help to treat many different diseases. The aim of this study was to evaluate the effects of homeopathy (H) as an adjunct for non-surgical periodontal therapy (NSPT) in individuals with DMII and CP. Eighty individuals with CP and DM II, of both sexes and aged between 32 and 70 years, participated in this randomized, double-blind, placebo-controlled study. They were divided into two groups: control group (CG) and the test group (TG), and both groups received the NSPT. TG also received homeopathic therapy, including Berberis, Mercurius solubilis\/Belladonna\/Hepar sulphur and Pyrogenium, while CG received placebo. Clinical and laboratorial examinations were evaluated at baseline and after 1, 6 and 12 months of treatment. Both groups showed significant improvement throughout the study, for most of the parameters studied, but TG presented significative gain of CAL at 1 and 12 months compared to CG. Mean glucose and glycated hemoglobin significantly decreased in both groups after 6 and 12 months. However, there was a significantly further reduction of these parameters in TG, as compared to CG. In conclusion, homeopathy as supplement of NSPT may further improve health condition, including glycemic control, in DMII patients with CP.<\/jats:p>","DOI":"10.1590\/0103-6440201902124","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T16:28:58Z","timestamp":1554568138000},"page":"139-145","source":"Crossref","is-referenced-by-count":6,"title":["Homeopathy and Periodontal Treatment in Type II Diabetic Patients: a 1-Year Randomized Clinical Trial"],"prefix":"10.1590","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8682-7580","authenticated-orcid":false,"given":"Leila","family":"Mour\u00e3o","sequence":"first","affiliation":[{"name":"Universidade Veiga de Almeida Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romeu","family":"Carillo Jr","sequence":"additional","affiliation":[{"name":"Universidade Cidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Martins","family":"Linares","sequence":"additional","affiliation":[{"name":"Instituto Estadual de Diabetes e Endocrinologia,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Canabarro","sequence":"additional","affiliation":[{"name":"Universidade Veiga de Almeida Rio de Janeiro,  Brazil; UERJ - Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Guimar\u00e3es","family":"Fischer","sequence":"additional","affiliation":[{"name":"UERJ - Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-051X.2010.01681.x","article-title":"Periodontal infections: understanding the complexity - Consensus of the Seventh European Workshop on Periodontology","volume":"38","author":"Sanz M","year":"2011","journal-title":"J Clin Periodontol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1902\/jop.2005.76.12.2187","article-title":"Strengthening the prevention of periodontal disease: the WHO approach","volume":"76","author":"Petersen PE","year":"2005","journal-title":"J Periodontol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-0757.2006.00193.x","article-title":"Diabetes mellitus and periodontal disease","volume":"44","author":"Mealey BL","year":"2007","journal-title":"Periodontol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nrendo.2011.183","article-title":"The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives","volume":"8","author":"Chen L","year":"2012","journal-title":"Nature Reviews Endocrinology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2337\/dc09-1778","article-title":"Periodontal status and A1C change: longitudinal results from the study of health in Pomerania (SHIP)","volume":"33","author":"Demmer RT","year":"2010","journal-title":"Diabetes Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-0757.2006.00168.x","article-title":"Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation","volume":"43","author":"Nassar H","year":"2007","journal-title":"Periodontol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/0022034510381902","article-title":"Periodontal disease and incident diabetes: a seven-year study","volume":"90","author":"Ide R","year":"2011","journal-title":"J Dent Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ctcp.2014.03.003","article-title":"Additional effects of homeopathy on chronic periodontitis: a 1-year follow-up randomized clinical trial","volume":"20","author":"Mour\u00e3o LC","year":"2014","journal-title":"Complement Ther Clin Pract"},{"key":"ref9","first-page":"1","article-title":"Periodontal diseases and homeopathy","volume":"5","author":"Srivastava P","year":"2012","journal-title":"Homeopathic J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.homp.2015.02.009","article-title":"Syzygium jambolanum and Cephalandra indica homeopathic preparations inhibit albumin glycation and protect erythrocytes: an in vitro study","volume":"104","author":"Tupe RS","year":"2015","journal-title":"Homeopathy"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.homp.2013.05.002","article-title":"Effect of homeopathic preparations of Syzygium jambolanum and Cephalandra indica on gastrocnemius muscle of high fat and high fructose-induced type-2 diabetic rats","volume":"102","author":"Sampath S","year":"2013","journal-title":"Homeopathy"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/2046-4053-3-142","article-title":"Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis","volume":"6","author":"Mathie RT","year":"2014","journal-title":"Syst Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-051X.2005.00822.x","article-title":"European Workshop in Periodontology group C. 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