{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:54:15Z","timestamp":1740142455785,"version":"3.37.3"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract Bone development and growth is a non-going, life-long process, varying greatly among individuals and much of this variation could be modulated by genetic factors. The purpose of this study was to evaluate the association between the polymorphisms in the TNF-a gene and skeletal class II malocclusion. Single nucleotide polymorphisms in TNF-a (rs1799724; rs1800629) gene were studied in 79 skeletal class II malocclusion and 102 skeletal class I malocclusion subjects from Straight Wire Group of Studies on Orthodontics and Functional Orthopedics for Maxillary from Rio de Janeiro, Brazil. The Genotyping of these selected polymorphisms was carried out by TaqMan real-time PCR using genomic DNA extracted from buccal cells. All allele and genotype frequencies were compared between the groups using the PLINK\u00ae software in a free, in a dominant and in a recessive model using a chi-square test (p\u22640.05). There was no significant association of TNF-a (rs1799724; rs1800629) genotype and allele distribution with skeletal class II malocclusion. Regardless of the dominant or recessive genetic model, the preferential genotype associations for rs1799724 and rs1800629 was insignificant. In conclusion, no evidence of association is apparent between genetic polymorphisms involving TNF-a and skeletal class II malocclusion or the position of the maxilla and mandible in the postero-anterior direction.<\/jats:p>","DOI":"10.1590\/0103-6440201902367","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T16:33:48Z","timestamp":1554568428000},"page":"152-156","source":"Crossref","is-referenced-by-count":5,"title":["Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion"],"prefix":"10.1590","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-2734","authenticated-orcid":false,"given":"Simone Carvalho","family":"Levy","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8432-0815","authenticated-orcid":false,"given":"L\u00edvia Azeredo Alves","family":"Antunes","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil; Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Guimaraes Barcellos de","family":"Abreu","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jullia Assis da Silva","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina","family":"Kuntz","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter Luis Soares","family":"Fialho","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Silva","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen Cardoso","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 de Albuquerque","family":"Calasans-Maia","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Calvo de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Smile Graduate School and Clinic,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika C.","family":"K\u00fcchler","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-6958","authenticated-orcid":false,"given":"Leonardo Santos","family":"Antunes","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil; 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