{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:29:22Z","timestamp":1792376962873,"version":"4.4.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract The present study aimed to evaluate clinical and microbiological effects of surgical and nonsurgical periodontal therapy in generalized aggressive periodontitis (GAgP) treatment. Sixteen GAgP patients were included in this randomized split-mouth design clinical trial. Maxillary quadrants were allocated into two groups: Nonsurgical Therapy (NST) and Surgical Therapy (ST). The following clinical parameters were assessed: plaque index (PI), bleeding on probing index (BoP), probing depth (PD), clinical attachment level (CAL) and gingival margin position (GMP). Concentrations of Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) in the subgingival biofilm were also determined. Clinical and microbiological parameters were assessed at baseline (n=16), 3 (n=15), 6 (n=15) and 12 months (n=8) after treatment. ST was able to promote higher PD reduction compared to NST in deep pockets at 12 months (p&lt;0.05) and in posterior teeth at 6 months (p&lt;0.05). In addition, higher gingival recession was observed in posterior teeth of the ST group at the 6th month (p&lt;0.05). However, ST failed to promoted additional CAL gain in any timepoint (p&gt;0.05). Moreover, microbiological evaluation showed no statistical difference in levels of Aa and Pg for both groups at all follow-up periods. Surgical therapy promoted similar clinical benefits to GAgP therapy. Moreover, both therapies failed to reduce Aa and Pg levels at different follow-up times.<\/jats:p>","DOI":"10.1590\/0103-6440201902930","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T19:26:49Z","timestamp":1574882809000},"page":"577-586","source":"Crossref","is-referenced-by-count":21,"title":["Clinical and Microbiological Evaluation of Surgical and Nonsurgical Treatment of Aggressive Periodontitis"],"prefix":"10.1590","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-947X","authenticated-orcid":false,"given":"Camila Camarinha da Silva","family":"Cirino","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-9583","authenticated-orcid":false,"given":"Hugo Felipe do","family":"Vale","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-0536","authenticated-orcid":false,"given":"M\u00e1rcio Zaffalon","family":"Casati","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-7091","authenticated-orcid":false,"given":"Enilson Antonio","family":"Sallum","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-5855","authenticated-orcid":false,"given":"Renato Corr\u00eaa Viana","family":"Casarin","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Wilson","family":"Sallum","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0140-6736(08)60135-X","article-title":"Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study","volume":"371","author":"Haubek D","year":"2008","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1600-0757.1999.tb00159.x","article-title":"Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment","volume":"20","author":"Slots J","year":"2000","journal-title":"Periodontol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1600-0765.2010.01278.x","article-title":"Levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin G in generalized aggressive and chronic periodontitis","volume":"45","author":"Casarin RC","year":"2010","journal-title":"J Periodontal Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1902\/jop.2005.76.2.289","article-title":"Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Chilean population","volume":"76","author":"Gajardo M","year":"2005","journal-title":"J Periodontol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1902\/jop.2007.060187","article-title":"Demographic, clinical, and microbiological aspects of chronic and aggressive periodontitis in Colombia: a multicenter study","volume":"78","author":"Lafaurie GI","year":"2007","journal-title":"J Periodontol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1399-302X.2007.00397.x","article-title":"Microbiological diversity of generalized aggressive periodontitis by 16S rRNA clonal analysis","volume":"23","author":"Faveri M","year":"2008","journal-title":"Oral Microbiol Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00784-013-1013-4","article-title":"Clinical results after nonsurgical therapy in aggressive and chronic periodontitis","volume":"18","author":"Scharf S","year":"2014","journal-title":"Clin Oral Investig"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1600-051X.2006.00965.x","article-title":"Prognostic factors in the treatment of generalized aggressive periodontitis: II. 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