{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:08:41Z","timestamp":1793052521779,"version":"4.5.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract Oral mucositis is a common inflammatory complication among patients with cancer. This study evaluated the histopathological, stereological, and antioxidant markers of 2% eucalyptus extract in induced oral mucositis in male golden hamsters. In this animal study, oral mucositis was induced in 30 male golden hamsters by 5-FU (60 mg\/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle once daily on days 3 and 4. On days 14-17, 2% eucalyptus hydroalcoholic extract gel and Calendula officinalis extract gel groups were treated and then compared with a non-treated control group. The histopathological and stereological scores and the pouch content of malondialdehyde, as well as the activities of glutathione and myeloperoxidase in the pouch tissue, were evaluated. Histopathologic scores of oral mucositis were lower in the eucalyptus gel group than those of the calendula and control groups (p&lt;0.05). Also, a lower malondialdehyde level and higher myeloperoxidase and glutathione activities were detected in the eucalyptus group in comparison to the calendula and control groups (p&lt;0.001). The thickness of the mucosa and submucosa increased in the eucalyptus group. The numerical density of the fibroblast and the volume density of the collagen significantly increased in the eucalyptus group. In conclusion, the use of eucalyptus hydroalcoholic extract may be associated with reduced intensity of oral mucositis, diminished concentration of malondialdehyde, increased activity of myeloperoxidase and glutathione, increased volume of mucosa and submucosa, increased fibroblast and collagen in the induced oral mucositis in golden hamsters undergoing 5-FU consumption.<\/jats:p>","DOI":"10.1590\/0103-6440202003140","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T13:11:39Z","timestamp":1594645899000},"page":"310-318","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Topical 2% Eucalyptus Extract on 5-FU-Induced Oral Mucositis in Male Golden Hamsters"],"prefix":"10.1590","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-1778","authenticated-orcid":false,"given":"Nader","family":"Tanideh","sequence":"first","affiliation":[{"name":"Shiraz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9791-6925","authenticated-orcid":false,"given":"Arash","family":"Badie","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-2306","authenticated-orcid":false,"given":"Raha","family":"Habibagahi","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9214-4375","authenticated-orcid":false,"given":"Omid","family":"koohi-Hosseinabadi","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3743-0931","authenticated-orcid":false,"given":"Sara","family":"Haghnegahdar","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-0512","authenticated-orcid":false,"given":"Azadeh","family":"Andisheh-Tadbir","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3126\/nje.v6i4.17255","article-title":"Changing Trends in oral cancer - a global scenario","volume":"6","author":"Gupta N","year":"2016","journal-title":"Nepal J Epidemiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijom.2011.10.011","article-title":"Cancer treatment-induced oral mucositis: a critical review","volume":"41","author":"Rodr\u00edguez-Caballero A","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2147\/tcrm.2006.2.2.159","article-title":"Oral mucositis induced by anticancer treatments: physiopathology and treatments","volume":"2","author":"D\u2019Hondt Lionel","year":"2006","journal-title":"Ther Clin Risk Manag"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/107327480200900504","article-title":"Treatment of locally advanced head and neck cancer: historical and critical review","volume":"9","author":"Al-Sarraf M","year":"2002","journal-title":"Cancer Control"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1007\/s00520-013-1869-5","article-title":"Systematic review of natural agents for the management of oral mucositis in cancer patients","volume":"21","author":"Yarom N","year":"2013","journal-title":"Support Care Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00520-011-1202-0","article-title":"A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis","volume":"19","author":"Bjordal J","year":"2011","journal-title":"Support Care Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.oooo.2012.08.450","article-title":"Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis","volume":"115","author":"Tanideh N","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.ijom.2014.05.013","article-title":"Comparative assessment of the therapeutic effects of the topical and systemic forms of Hypericumperforatum extract on induced oral mucositis in golden hamsters","volume":"43","author":"Tanideh N","year":"2014","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/jop.12540","article-title":"Healing acceleration of oral mucositis induced by 5-fluorouracil with Pistaciaatlantica (bene) essential oil in hamsters","volume":"46","author":"Tanideh N","year":"2017","journal-title":"J Oral Pathol Med"},{"key":"ref10","article-title":"Comparison of the therapeutic effects of the dietary and topical forms of Zizyphusjujuba extract on oral mucositis induced by 5-fluorouracil: a golden hamster model","volume":"7","author":"Koohi-Hosseinabadi O","year":"2015","journal-title":"J Clin Exp Dent"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ptr.2051","article-title":"Chemical composition and antimicrobial activity of the essential oils from two species of Eucalyptus","volume":"21","author":"Sartorelli P","year":"2007","journal-title":"Phytother Res"},{"key":"ref12","first-page":"234","article-title":"Eucalyptus camaldulensis properties for use in the eradication of infections. 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