{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:29:54Z","timestamp":1792801794333,"version":"4.5.0"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"5","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract New methods of early detection and risk assessment have been studied aiming to predict the prognosis of patients and directing a specialized treatment of the oral tongue squamous cell carcinoma (OTSCC). In this context, several molecular biomarkers have been investigated for this purpose, and, among them, the heat shock protein 27 (HSP27) can be named. The study aimed to analyze whether heat shock protein 27 (HSP27) exerts any influence on OTSCC, correlating its immunoexpression with clinicopathological parameters, and patient survival. The sample comprised 55 OTSCC cases and 20 normal oral mucosa specimens. The malignancy grading systems proposed by the WHO in 2005, Brandwein-Gensler et al., and Almangush et al. were applied in a histomorphological study. HSP27 expressions were evaluated through the Immunoreactivity Score System (IRS). Significant values were considered at p &lt;0.05 for all statistical tests. Higher IRS results were observed for normal oral mucosa specimens when compared to OTSCC cases (p &lt;0.001). No significant associations between HSP27 immunostaining, the analyzed clinicopathological parameters and patient survival were observed. The results of the present study indicate lower HSP27 expression in OTSCC cases compared to normal oral mucosa specimens. Thus, HSP27 expression does not seem to influence patient prognosis.<\/jats:p>","DOI":"10.1590\/0103-6440202305036","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T09:58:31Z","timestamp":1703239111000},"page":"125-133","source":"Crossref","is-referenced-by-count":1,"title":["Immunoexpression of HSP27 does not seem to influence the prognosis of oral tongue squamous cell carcinoma"],"prefix":"10.1590","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-0934","authenticated-orcid":false,"given":"Ondina Karla Mousinho Rocha","family":"Torres","sequence":"first","affiliation":[{"name":"Federal University of Rio Grande do Norte,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-6581","authenticated-orcid":false,"given":"Luiz Arthur Barbosa da","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7577-5375","authenticated-orcid":false,"given":"Roseana de Almeida","family":"Freitas","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2128-0147","authenticated-orcid":false,"given":"\u00c9ricka Janine Dantas da","family":"Silveira","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-2566","authenticated-orcid":false,"given":"M\u00e1rcia Cristina da Costa","family":"Miguel","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2023,10]]},"reference":[{"key":"ref1","article-title":"Development of a novel 7 immune-related genes prognostic model for oral cancer: A study based on TCGA database","volume":"112","author":"Zhao XT","year":"2021","journal-title":"Oral Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3892\/or.2020.7854","article-title":"Diagnostic and therapeutic role of microRNAs in oral cancer (Review)","volume":"45","author":"Wang J","year":"2021","journal-title":"Oncol Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/JMAU.JMAU_48_19","article-title":"Differential Expression of Heat Shock Protein 27 in Oral Epithelial Dysplasias and Squamous Cell Carcinoma","volume":"28","author":"Karri RL Subramanyam RV","year":"2020","journal-title":"J Microsc 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