{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:53:42Z","timestamp":1740142422186,"version":"3.37.3"},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract The objective of this study was to map, through a scoping review, the evidence available in the literature on the use of platelet concentrates in compromised patients undergoing oral surgeries. Searches were performed in electronic databases for clinical studies with compromised patients undergoing oral surgery who used platelet concentrates. Only studies published in English were included. Two independent researchers carried out the selection of studies. The study design and objective, surgical procedure and platelet concentrate used, systemic involvement, analyzed outcome, and main results were extracted. A descriptive analysis of the data was performed. Twenty-two studies met the eligibility criteria and were included. Case series was the most frequent study design among the included studies (41.0%). In terms of systemic disability, 19 studies reported patients with cancer and related to surgical treatment 16 studies reported patients underwent treatment for osteonecrosis related to the use of the drug. The most used platelet concentrate was pure platelet-rich fibrin (P-PRF). In general, most studies recommend the use of platelet concentrates. Thus, the results of this study suggest that the evidence related to the use of platelet concentrates in compromised patients when undergoing oral surgeries is still initial. Also, most studies assessed the use of platelet concentrates in patients with osteonecrosis.<\/jats:p>","DOI":"10.1590\/0103-6440202305254","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T15:20:57Z","timestamp":1685373657000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Use of platelet concentrates in oral surgery of patients with osteonecrosis: a scoping review"],"prefix":"10.1590","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-3355","authenticated-orcid":false,"given":"Carlos Eduardo Dutra","family":"Rufato","sequence":"first","affiliation":[{"name":"Atitus Education,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1094-8148","authenticated-orcid":false,"given":"Mayara Colpo","family":"Prado","sequence":"additional","affiliation":[{"name":"Atitus Education,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-3865","authenticated-orcid":false,"given":"Renan Luiz","family":"Luft","sequence":"additional","affiliation":[{"name":"University of Ribeir\u00e3o Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5774-6492","authenticated-orcid":false,"given":"Dionatan","family":"Zauza","sequence":"additional","affiliation":[{"name":"Atitus Education,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-1656","authenticated-orcid":false,"given":"Yara T. C.","family":"Silva-Sousa","sequence":"additional","affiliation":[{"name":"Atitus Education,  Brazil; University of Ribeir\u00e3o Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5477-4077","authenticated-orcid":false,"given":"Mateus Bertolini Fernandes dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Federal University of Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1514-7879","authenticated-orcid":false,"given":"Rafael","family":"Sarkis-Onofre","sequence":"additional","affiliation":[{"name":"Atitus Education,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fcvm.2019.00126","article-title":"Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration","volume":"6","author":"Al-Hamed FS","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)","volume":"27","author":"Dohan Ehrenfest DM","year":"2009","journal-title":"Trends Biotechnol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/0898756419876057","article-title":"Use of Platelet-Rich Plasma and Platelet-Rich Fibrin in Dentistry and Oral Surgery: Introduction and Review of the Literature","volume":"36","author":"Feigin K.","year":"2019","journal-title":"Journal of Veterinary Dentistry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1172\/JCI0215463","article-title":"Circulating levels of IGF-1 directly regulate bone growth and density","volume":"110","author":"Yakar S","year":"2002","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1089\/ten.tea.2014.0189","article-title":"Transforming growth factor beta 1 augments calvarial defect healing and promotes suture regeneration","volume":"21","author":"Shakir S","year":"2015","journal-title":"Tissue Eng Part A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrrheum.2013.141","article-title":"Platelet-rich plasma for managing pain and inflammation in osteoarthritis","volume":"9","author":"Andia I","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1902\/jop.2007.060302","article-title":"Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties","volume":"78","author":"El-Sharkawy H","year":"2007","journal-title":"J Periodontol"},{"issue":"18","key":"ref8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/clr.13296","article-title":"The use of platelet-rich plasma to enhance the outcomes of implant therapy: A systematic review","volume":"29","author":"St\u00e4hli A","year":"2018","journal-title":"Clin Oral Implants Res"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.bdj.2013.830","article-title":"Oral surgery: part 1. Introduction and the management of the medically compromised patient","volume":"215","author":"Renton T.","year":"2013","journal-title":"British Dental Journal"},{"key":"ref10","series-title":"JBI Manual for Evidence Synthesis, JBI","volume-title":"Chapter 11: Scoping Reviews (2020 version)","author":"Peters MDJ","year":"2020"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation","volume":"169","author":"Tricco AC","year":"2018","journal-title":"Ann Intern Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e799","DOI":"10.4317\/medoral.23804","article-title":"Leukocyte- and platelet-rich fibrin does not provide any additional benefit for tooth extraction in head and neck cancer patients post-radiotherapy: a randomized clinical trial","volume":"25","author":"Palma LF","year":"2020","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.joms.2016.12.005","article-title":"Does the Addition of Bone Morphogenetic Protein 2 to Platelet-Rich Fibrin Improve Healing After Treatment for Medication-Related Osteonecrosis of the Jaw?","volume":"75","author":"Park JH","year":"2017","journal-title":"J Oral Maxillofac Surg"},{"key":"ref14","article-title":"Combined approach to treatment of advanced stages of medication-related osteonecrosis of the jaw patients","author":"\u015eahin O","year":"2021","journal-title":"Braz J Otorhinolaryngol"},{"key":"ref15","article-title":"Prevention of medication related osteonecrosis of the jaw after dentoalveolar surgery: An institution's experience","volume":"12","author":"\u015eahin O","year":"2020","journal-title":"J Clin Exp Dent"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1186\/s12903-021-01965-7","article-title":"Promising results of surgical management of advanced medication related osteonecrosis of the jaws using adjunctive leukocyte and platelet rich fibrin","volume":"21","author":"\u00d6zalp \u00d6","year":"2021","journal-title":"BMC Oral Health"},{"key":"ref17","first-page":"1","article-title":"Efficacy of fibrin-rich platelets and leukocytes (L-PRF) in tissue repair in surgical oral procedures in patients using zoledronic acid-case-control study","volume":"24","author":"Parise GK","year":"2022","journal-title":"Oral Maxillofac Surg"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1111\/dth.13334","article-title":"Autologous platelet-rich fibrin injections in the management of facial cutaneous sinus tracts secondary to medication-related osteonecrosis of the jaw","volume":"33","author":"Bennardo F","year":"2020","journal-title":"Dermatol Ther"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s12663-019-01278-x","article-title":"Management of Large Oroantral Fistulas Caused by Medication-Related Osteonecrosis with the Combined Sequestrectomy, Buccal Fat Pad Flap and Platelet-Rich Fibrin","volume":"20","author":"Esen A","year":"2021","journal-title":"J Maxillofac Oral Surg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jormas.2019.02.011","article-title":"The use of Platelet-rich Fibrin in the management of medication-related osteonecrosis of the jaw: A case series","volume":"121","author":"Mour\u00e3o FABC","year":"2020","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.oooo.2018.06.007","article-title":"Can platelet-rich fibrin improve healing after surgical treatment of medication-related osteonecrosis of the jaw?","volume":"126","author":"Giudice A","year":"2018","journal-title":"A pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/jcm11030682","article-title":"Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw","volume":"28","author":"Blatt S","year":"2022","journal-title":"J Clin Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s00784-016-2004-z","article-title":"Platelet-rich fibrin may reduce the risk of delayed recovery in tooth-extracted patients undergoing oral bisphosphonate therapy: a trial study","volume":"21","author":"Asaka T","year":"2017","journal-title":"Clin Oral Investig"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4948139","article-title":"The Role of Platelet-Rich Fibrin (PRF) in the Prevention of Medication-Related Osteonecrosis of the Jaw (MRONJ)","author":"Miranda M","year":"2021","journal-title":"Biomed Res Int"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jcms.2020.02.006","article-title":"Tooth extractions in patients under antiresorptive therapy for osteoporosis: Primary closure of the extraction socket with a mucoperiosteal flap versus application of platelet-rich fibrin for the prevention of antiresorptive agent-related osteonecrosis of the jaw","volume":"48","author":"Poxleitner P","year":"2020","journal-title":"J Craniomaxillofac Surg"},{"key":"ref26","article-title":"Platelet rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw: personal experience and review of the literature","author":"Longo F","year":"2014","journal-title":"Int J Dent"},{"key":"ref27","first-page":"151","article-title":"Platelet-rich plasma improves wound healing in multiple myeloma bisphosphonate-associated osteonecrosis of the jaw patients","volume":"26","author":"Coviello V","year":"2012","journal-title":"J Biol Regul Homeost Agents"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.15171\/jlms.2018.19","article-title":"Combined Approach to Treat Medication-Related Osteonecrosis of the Jaws","volume":"9","author":"Merigo E","year":"2018","journal-title":"J Lasers Med Sci"},{"key":"ref29","article-title":"Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study","author":"Mauceri R","year":"2018","journal-title":"Biomed Res Int"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.oraloncology.2011.08.010","article-title":"Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: a preliminary study","volume":"48","author":"Martins MA","year":"2012","journal-title":"Oral Oncol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"971","DOI":"10.14219\/jada.archive.2007.0294","article-title":"The treatment of bisphosphonate-associated osteonecrosis of the jaws with bone resection and autologous platelet-derived growth factors","volume":"138","author":"Adornato MC","year":"2007","journal-title":"J Am Dent Assoc"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.oraloncology.2011.12.004","article-title":"Platelet-rich therapies in the treatment of intravenous bisphosphonate-related osteonecrosis of the jaw: a report of 32 cases","volume":"48","author":"Mozzati M","year":"2012","journal-title":"Oral Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.joms.2010.07.026","article-title":"Initial experience on the outcome of teeth extractions in intravenous bisphosphonate-treated patients: a cautionary report","volume":"69","author":"Scoletta M","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/ebmed-2016-110401","article-title":"New evidence pyramid","volume":"21","author":"Murad MH","year":"2016","journal-title":"Evid Based Med"},{"key":"ref35","first-page":"561","article-title":"Case reports: their role in a medical journal","volume":"83","author":"Gontijo B","year":"2008","journal-title":"An Bras Dermatol"},{"key":"ref36","series-title":"Fundamentals of Clinical Trials","author":"Friedman LM","year":"2015","edition":"5\u00aa ed."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejca.2014.10.015","article-title":"Autologous platelet concentrates for bisphosphonate-related osteonecrosis of the jaw treatment and prevention","volume":"51","author":"Del Fabbro M","year":"2015","journal-title":"A systematic review of the literature. Eur J Cancer"},{"key":"ref38","article-title":"Autologous platelet concentrates in extraction sockets for the prevention of osteoradionecrosis: a systematic review of controlled clinical trials [published online ahead of print, 2022 Jan 20]","author":"Serrano RV","year":"2022","journal-title":"Oral Maxillofac Surg"}],"container-title":["Brazilian Dental Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0103-64402023000200001&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T15:21:15Z","timestamp":1685373675000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0103-64402023000200001&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["S0103-64402023000200001"],"URL":"https:\/\/doi.org\/10.1590\/0103-6440202305254","relation":{},"ISSN":["1806-4760","0103-6440"],"issn-type":[{"type":"electronic","value":"1806-4760"},{"type":"print","value":"0103-6440"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}