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Dent. J."],"abstract":"<jats:p>Abstract Physicochemical properties, bond strength, and antibiofilm activity of a powder-gel bioceramic endodontic sealer, Sealer Plus BC (SPBC, MK Life, Porto Alegre, RS, Brazil), were evaluated in comparison with Bio-C Sealer (BCS, Angelus, Londrina, PR, Brazil), a reference bioceramic sealer, and AH Plus Jet (AHP, Dentsply DeTrey, Konstanz, Germany), a standard resin-based sealer. The setting time, pH, solubility, flow, and radiopacity were evaluated in accordance with ISO 6876:2012 standards. Bond strength was measured using the Push-Out test. Antibiofilm activity against Enterococcus faecalis alone or in combination with Candida albicans was assessed using a modified direct contact test with the eluate of fresh sealer (25 mg\/mL) and after 24 hours of material setting. The data were analyzed using ANOVA and Tukey statistical tests (\u03b1 = 0.05). SPBC exhibited higher Setting Time values compared to BCS and lower values compared to AHP (p &lt; 0.05). BCS and SPBC had higher solubility values than 3% (p&lt;0.05). BCS demonstrated flow values higher than those of SPBC and AHP (p&lt;0.05). SPBC showed lower radiopacity (p&lt;0.05) and higher bond strength (p&lt;0.05) than BCS and AHP. SPBC and BCS exhibited alkaline pH throughout all evaluated periods. They demonstrated antimicrobial activity against Enterococcus faecalis and\/or Candida albicans in the eluate of fresh sealer and 24 hours after setting (p &lt; 0.05). In conclusion, SPBC powder-gel sealer, as a filling material, meets most ISO 6876 standards for physicochemical properties, demonstrates bond strength to dentin, and exhibits antimicrobial activity against both dual and single-specimen biofilms. However, it has a solubility greater than 3%.<\/jats:p>","DOI":"10.1590\/0103-644020246325","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:02:29Z","timestamp":1764601349000},"source":"Crossref","is-referenced-by-count":1,"title":["Physicochemical properties, bond strength, and antibiofilm activity of a powder-gel bioceramic endodontic sealer"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3591-7364","authenticated-orcid":false,"given":"J\u00e9ssica Arielli","family":"Pradelli","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2194-7475","authenticated-orcid":false,"given":"Pedro Lu\u00eds Busto","family":"Rosim","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1916-1675","authenticated-orcid":false,"given":"Airton Oliveira","family":"Santos-Junior","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-4706","authenticated-orcid":false,"given":"Mario","family":"Tanomaru-Filho","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0446-2037","authenticated-orcid":false,"given":"Juliane Maria","family":"Guerreiro-Tanomaru","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1590\/0103-6440201902607","article-title":"Solubility, Porosity, Dimensional and Volumetric Change of Endodontic Sealers","volume":"30","author":"Torres FFE","year":"2019","journal-title":"Braz Dent J"},{"key":"ref2","first-page":"15","article-title":"Evaluation of Bond Strength of Four Different Root Canal Sealers","author":"Cimpean SI","year":"2022","journal-title":"Materials"},{"key":"ref3","first-page":"1","article-title":"Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review","volume":"14","author":"Muniti\u0107 MS","year":"2019","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.joen.2019.07.006","article-title":"Evaluation of Physicochemical Properties of a New 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