{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T15:09:55Z","timestamp":1761318595218,"version":"build-2065373602"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract This study aimed to assess tumor necrosis factor-alpha (TNF-\u03b1) expression in peri-implant crevicular fluid (PICF) of patients receiving peri-implant supportive therapy. Twenty-six participants with implant-supported prostheses, functioning for at least 1 year, were divided into two groups: control (peri-implant health, n=8) and mucositis (peri-implant mucositis, n=18). All underwent clinical and radiographic exams and received non-invasive therapy (mechanical debridement, with ultrasonic scalers to remove calculus and sodium air-abrasive polishing to eliminate soft debris from the implant and prosthetic components + 0.12% chlorhexidine). Timepoints were: Time 1 (initial diagnosis\/treatment); Time 2 (15 days post-diagnosis); Time 3 (21 days after). PICF samples collected at each time point analyzed TNF-\u03b1 levels via ELISA. While clinical parameters showed no group differences, a trend (p=0.07) towards more keratinized gingiva in controls was noted. Significant TNF-\u03b1 differences were found over time in the control group (p = 0.029, Kruskal-Wallis), with Dunn's test showing T2\/T3 differences (p=0.03). The Mucositis group showed no time differences (p=0.96). Over 36 days, no significant difference (p=0.86, Kruskal-Wallis) was found between the control and mucositis groups. TNF-\u03b1 levels decreased significantly after 36 days in both groups, more so in controls. Therapy reduced mucositis from 70% to 23%. Overall, while TNF-\u03b1 levels alone may not conclusively differentiate between healthy and mucositis-affected sites in every context, they do appear to correlate with improvements in peri-implant health following therapeutic intervention.<\/jats:p>","DOI":"10.1590\/0103-644020256205","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T15:02:05Z","timestamp":1761318125000},"source":"Crossref","is-referenced-by-count":0,"title":["Peri-implant health is associated with low levels of TNF-\u03b1"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5479-8404","authenticated-orcid":false,"given":"Juliana Prazeres Gon\u00e7alves de","family":"Castro","sequence":"first","affiliation":[{"name":"Fluminense Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-9364","authenticated-orcid":false,"given":"Valquiria","family":"Quinelato","sequence":"additional","affiliation":[{"name":"Fluminense Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-7106","authenticated-orcid":false,"given":"Luiza dos Anjos","family":"Motta","sequence":"additional","affiliation":[{"name":"Fluminense Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1550-5680","authenticated-orcid":false,"given":"Telma Regina da Silva","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Fluminense Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-7604","authenticated-orcid":false,"given":"Aldir Nascimento","family":"Machado","sequence":"additional","affiliation":[{"name":"Fluminense Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-0190","authenticated-orcid":false,"given":"Priscila Ladeira","family":"Casado","sequence":"additional","affiliation":[{"name":"Fluminense Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-051X.2008.01283.x","article-title":"Peri-implant diseases: Consensus report of the Sixth European Workshop on Periodontology","volume":"35","author":"Lindhe J","year":"2008","journal-title":"Journal of Clinical Periodontology"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/idj.12511","article-title":"Local risk indicators - Consensus report of working group","volume":"69","author":"Giovannoli J L","year":"2019","journal-title":"Int Dent J"},{"issue":"1","key":"ref3","first-page":"3","article-title":"Genetic and acquired risk factors, and prevalence of peri\u2010implant diseases: consensus report of working group 1","volume":"69","author":"eyle J","year":"2019","journal-title":"Int Dent J"},{"issue":"20","key":"ref4","first-page":"S286","article-title":"Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.","volume":"45","author":"Berglundh T","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"21","key":"ref5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/clr.13827","article-title":"Peri-implantitis: Summary and consensus statements of group 3. 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