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Dent. J."],"abstract":"<jats:p>Abstract This research aims to evaluate whether blue\u00aem mouthwash can be used as a suitable alternative to chlorhexidine mouthwash for improving the oral health of intubated patients in ICUs. This is a randomized clinical study. The sample comprised 50 mechanically ventilated adults randomly allocated in a block of 10 to the 0.12% chlorhexidine digluconate (CHX) and the blue\u00aem group. The patients' oral and tracheal secretions were collected in four different periods: T1 - 24h after intubation (without sanitation); T2 - 24h after intubation (with sanitation); T3 - 48h after intubation (without sanitation); T4 - 48h after intubation (with sanitation). Bacterial and fungal identification was performed. The presence of bacteria was graded as abundant, moderate, and scarce. Descriptive and inferential statistics were performed. Fifty patients with a mean age of 62.7 \u00b1 13.3 years (20 to 86 years) were treated, 24 in the CHX group and 26 in the blue\u00aem group. The most frequent pathogens in the patient's oral environment were Acinetobacter baumanii, Pseudomonas aeruginosa, and Klebsiella pneumonia. Analysis of the effectiveness of both antiseptics indicated statistically significant differences in the median values of the microbial population between collection periods in the CHX (\u03c72=13.2, p=0.004) and blue\u00aem (\u03c72=9.49, p=0.023) group. No significant statistical difference in microbial population was found between the groups (T1- p=0.375; T2 - p=0.955; T3 - p=0.765; T4 - p=0.898). Blue\u00aem mouthwash effectively reduces the oral microbial population and does not differ from chlorhexidine in terms of reduction. Blue\u00aem mouthwash can be used as an alternative to chlorhexidine for mechanical ventilator patients in the ICU.<\/jats:p>","DOI":"10.1590\/0103-644020256537","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T15:09:08Z","timestamp":1765206548000},"source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Blue\u00aem and chlorhexidine mouthwash on oral health of intubated patients in intensive care unit"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6099-8313","authenticated-orcid":false,"given":"Tereza C.","family":"Teixeira","sequence":"first","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Sorocaba,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1961-1107","authenticated-orcid":false,"given":"Renan A.G.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Sorocaba,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6300-2576","authenticated-orcid":false,"given":"Valeriana","family":"Mascella","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Sorocaba,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4076-4905","authenticated-orcid":false,"given":"Tatiana M.","family":"Deliberador","sequence":"additional","affiliation":[{"name":"Latin American Institute of Odontological Research and Education,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1186\/s12903-024-04456-7","article-title":"Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit","volume":"24","author":"Oshvandi K","year":"2024","journal-title":"BMC Oral Health"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12028-019-00773-w","article-title":"Incidence, risk factors, and outcomes of ventilator-associated pneumonia in traumatic brain injury: a meta-analysis","volume":"32","author":"Li Y","year":"2020","journal-title":"Neurocrit Care"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1186\/s12903-024-04412-5","article-title":"Effect of propolis mouthwash on the incidence of ventilator-associated pneumonia in intensive care unit patients: a comparative randomized triple-blind clinical trial","volume":"24","author":"Darbanian N","year":"2024","journal-title":"BMC Oral Health"},{"key":"ref4","article-title":"Oral hygiene care for critically ill patients to prevent ventilator\u2010associated pneumonia","volume":"12","author":"Zhang Q","year":"2020","journal-title":"Cochrane 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adults\u2019 intensive care units","volume":"40","author":"Zand F","year":"2017","journal-title":"J Crit Care"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1590\/0103-6440202305133","article-title":"Effects of BlueM\u00ae against Streptococcus mutans biofilm and its virulence gene expression","volume":"34","author":"Santos VCE dos","year":"2023","journal-title":"Braz Dent J"},{"issue":"S2","key":"ref9","doi-asserted-by":"crossref","first-page":"S220","DOI":"10.5005\/jp-journals-10015-2137","article-title":"Oxygen-releasing Gel vs 0.2% Chlorhexidine Gel as an Adjuvant to Scaling and Root Planing: A Randomized Controlled Trial","volume":"13","author":"Bali S","year":"2022","journal-title":"World Journal of Dentistry"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4103\/ajprhc.ajprhc_25_24","article-title":"Comparative Evaluation of 0.2% Chlorhexidine and Oxygenated Mouthwash as an Adjunct to Scaling and Root 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management of patients with chronic periodontitis--A clinico-microbiological study","volume":"7","author":"Koul A","year":"2019","journal-title":"Journal of Dental Specialities"},{"key":"ref21","article-title":"Antimicrobial Photodynamic Therapy Associated to Blue\u00ae m Over Oral Biofilms Responsible by Endocarditis","volume":"41","author":"Rastelli AN","year":"2023","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2024.1474583","article-title":"A multimodal in vitro approach to assess the safety of oral care products using 2D and 3D cellular models","volume":"6","author":"Leano SM","year":"2024","journal-title":"Frontiers in Toxicology"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.ajic.2014.05.007","article-title":"Epidemiology of pathogens and drug resistance of ventilator-associated pneumonia in Chinese neonatal intensive care units: a 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