{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:13:22Z","timestamp":1766157202671,"version":"3.48.0"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract Temporomandibular disorders (TMD) include changes related to the presence of orofacial pain, limited mouth opening, and inflammatory issues. These inflammatory issues are related to interleukins, which are inflammatory mediators. Thus, the presence of genetic polymorphisms in genes that encode interleukins could impact TMD. Therefore, this cross-sectional study aimed to assess the impact of genetic polymorphisms in the genes encoding interleukins on the oral health-related quality of life (OHRQoL) of individuals with TMD. A total of 230 male construction workers were evaluated regarding the presence of TMD with or without pain, as well as changes in the temporomandibular joint (TMJ), using the Research Diagnostic Criteria for Temporomandibular Disorders (RDC\/TMD). OHRQoL was assessed using the 14-item Oral Health Impact Profile (OHIP-14). DNA extracted from saliva was used to evaluate the genetic polymorphisms in IL1B (rs1143627 and rs1143629) and IL6 (rs1800795 and rs1800796) using real-time polymerase chain reaction. Student's t-test or ANOVA was used for statistical analysis (alpha=5%). An association between OHIP-14 and TMD was observed (p&lt;0.05). Individuals\u2019 heterozygous AG in rs1143629 showed increased values in domains 2 (physical pain) and 4 (physical disability) compared to AA homozygotes (p=0.035; p=0.042, respectively). Individuals homozygous for the C allele at rs1800796 demonstrated higher values in domain 7 (handicap) compared to heterozygous CG and homozygous GG individuals (p=0.007). In conclusion, our study supported the hypothesis that TMD and genetic polymorphisms associated with inflammatory disorders are associated with OHRQoL<\/jats:p>","DOI":"10.1590\/0103-644020256581","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:05:04Z","timestamp":1766156704000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of Cytokine Genes on TMD and QoL in Construction Workers"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1875-9406","authenticated-orcid":false,"given":"Andr\u00e9 Miquilussi","family":"Moreira","sequence":"first","affiliation":[{"name":"Tuiuti University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6682-5601","authenticated-orcid":false,"given":"Samantha Schaffer Pugsley","family":"Baratto","sequence":"additional","affiliation":[{"name":"UniDomBosco University Center,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2421-9502","authenticated-orcid":false,"given":"D\u00e9bora Cristina Cardozo","family":"Bueno","sequence":"additional","affiliation":[{"name":"Tuiuti University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5032-0948","authenticated-orcid":false,"given":"Gisele Maria","family":"Correr","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-4248","authenticated-orcid":false,"given":"Cristiano Miranda de","family":"Araujo","sequence":"additional","affiliation":[{"name":"Tuiuti University of Paran\u00e1,  Brazil; University of Joinville,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-8724","authenticated-orcid":false,"given":"Christian","family":"Kirschneck","sequence":"additional","affiliation":[{"name":"University Hospital Bonn,  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6170-1914","authenticated-orcid":false,"given":"Bianca","family":"Cavalcante-Le\u00e3o","sequence":"additional","affiliation":[{"name":"Tuiuti University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-7234","authenticated-orcid":false,"given":"Erika Calvano","family":"K\u00fcchler","sequence":"additional","affiliation":[{"name":"University Hospital Bonn,  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-2526","authenticated-orcid":false,"given":"Flares","family":"Baratto-Filho","sequence":"additional","affiliation":[{"name":"Tuiuti University of Paran\u00e1,  Brazil; University of Joinville,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-2373","authenticated-orcid":false,"given":"Michelle Nascimento","family":"Megerx","sequence":"additional","affiliation":[{"name":"Tuiuti University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13051365","article-title":"A Meta-Analysis of the Global Prevalence of Temporomandibular Disorders","volume":"13","author":"Zielinski G","year":"2024","journal-title":"J Clin Med"},{"issue":"1","key":"ref2","first-page":"17","article-title":"Signs and symptoms of temporomandibular disorders in women and men","volume":"28","author":"Ferreira CL","year":"2016","journal-title":"Codas"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","article-title":"Diagnostic Criteria for Temporomandibular Disorders (DC\/TMD) for Clinical and Research Applications: recommendations of the International RDC\/TMD Consortium Network* and Orofacial Pain Special Interest Groupdagger","volume":"28","author":"Schiffman E","year":"2014","journal-title":"J Oral Facial Pain Headache"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/joor.13472","article-title":"Impact of temporomandibular disorders on oral health-related quality of life: A systematic review and meta-analysis","volume":"50","author":"Qamar Z","year":"2023","journal-title":"J Oral Rehabil"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1007\/s11136-020-02581-8","article-title":"Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery","volume":"29","author":"Sebastiani AM","year":"2020","journal-title":"Qual Life Res"},{"issue":"4","key":"ref6","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin SF","year":"1992","journal-title":"J Craniomandib Disord"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00784-023-04925-3","article-title":"Genetic polymorphisms are involved in oral health-related quality of life in skeletal class III patients submitted to orthognathic surgery","volume":"27","author":"Meger MN","year":"2023","journal-title":"Clin Oral Investig"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: a social signal transduction theory of depression","volume":"140","author":"Slavich GM","year":"2014","journal-title":"Psychol Bull"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s11136-014-0656-1","article-title":"Biological pathways, candidate genes, and molecular markers associated with quality-of-life domains: an update","volume":"23","author":"Sprangers MA","year":"2014","journal-title":"Qual Life Res"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1590\/0103-6440202204963","article-title":"Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes","volume":"33","author":"Baratto SSP","year":"2022","journal-title":"Braz Dent J"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2188\/jea.JE20150173","article-title":"Evaluation of the Endorsement of the STrengthening the REporting of Genetic Association Studies (STREGA) Statement on the Reporting Quality of Published Genetic Association Studies","volume":"26","author":"Nedovic D","year":"2016","journal-title":"J Epidemiol"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1590\/S1678-77572012000400013","article-title":"Buccal cells DNA extraction to obtain high quality human genomic DNA suitable for polymorphism genotyping by PCR-RFLP and Real-Time PCR","volume":"20","author":"Kuchler EC","year":"2012","journal-title":"J Appl Oral Sci"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph182413412","article-title":"Use of Oral Health Impact Profile-14 (OHIP-14) in Different Contexts. 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