{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:57:18Z","timestamp":1768258638424,"version":"3.49.0"},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. Dent. J."],"abstract":"<jats:p>Abstract Erosive tooth wear (ETW) compromises enamel integrity. This study investigated the synergistic effects of bioactive silica and fluoride, as well as the independent performance of bioactive silica, in protecting sound enamel and repairing previously eroded enamel under erosive-abrasive challenges. An in vitro laboratory design was adopted using two models: (1) a protective model with sound enamel and (2) a remineralizing model with pre-eroded enamel. Ninety-six bovine enamel blocks were randomly allocated to four dentifrice groups (n=12\/group) within two experimental models: RGS\/NaF (bioactive silica + 1100 ppm NaF), RGS (bioactive silica without fluoride), NaF (1100 ppm NaF), and NC (fluoride\/silica-free). Specimens were exposed to erosive cycling with 0.1% citric acid and simulated toothbrushing treatment for seven days (protective model) or five days (remineralizing model). Surface microhardness, quantitative light-induced fluorescence (QLF), 3D profilometry, and roughness were evaluated. Data were analyzed with ANOVA and Tukey\u2019s post hoc test (p &lt; 0.05). In the protective model, all groups showed microhardness loss, but RGS\/NaF maintained the highest hardness values (p &lt; 0.05). In the remineralizing model, all groups demonstrated partial recovery, with RGS\/NaF significantly outperforming the others. Bioactive silica alone performed similarly to NaF in several parameters, showing reduced roughness and less structural loss compared with the negative control. The combination of bioactive silica and fluoride provided superior protective and remineralizing effects against erosive-abrasive enamel loss. Bioactive silica alone also exhibited relevant benefits, reinforcing its potential as a viable fluoride-free alternative.<\/jats:p>","DOI":"10.1590\/0103-644020256847","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:02:06Z","timestamp":1768230126000},"source":"Crossref","is-referenced-by-count":0,"title":["Synergistic effects of bioactive silica and fluoride in enamel protection and repair: an in vitro study"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5634-621X","authenticated-orcid":false,"given":"Juliellen Luiz da","family":"Cunha","sequence":"first","affiliation":[{"name":"Para\u00edba Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3378-3754","authenticated-orcid":false,"given":"Anderson Gomes","family":"Forte","sequence":"additional","affiliation":[{"name":"University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-9848","authenticated-orcid":false,"given":"Elizabeth Barreto Galv\u00e3o de","family":"Souza","sequence":"additional","affiliation":[{"name":"Para\u00edba Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-2239","authenticated-orcid":false,"given":"Marcel Alves Avelino de","family":"Paiva","sequence":"additional","affiliation":[{"name":"Para\u00edba Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9645-6679","authenticated-orcid":false,"given":"Adriana Moreira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Para\u00edba Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-5579","authenticated-orcid":false,"given":"Rebeca Tibau Aguiar","family":"Dias","sequence":"additional","affiliation":[{"name":"Para\u00edba Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2870-5742","authenticated-orcid":false,"given":"F\u00e1bio Correia","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Para\u00edba Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-486X","authenticated-orcid":false,"given":"Andressa Feitosa Bezerra de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Para\u00edba Federal University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41432-023-00966-5","article-title":"The role of calcium in the prevention of erosive tooth wear: a systematic review and meta-analysis","volume":"25","author":"Chatzidimitriou K","year":"2024","journal-title":"Evid Based Dent"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jerd.12706","article-title":"Contemporary diagnosis and management of dental erosion","volume":"33","author":"Donovan T","year":"2021","journal-title":"J Esthet Restor Dent"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2021-0081","article-title":"Protection of calcium silicate\/sodium phosphate\/fluoride toothpaste with serum on enamel and dentin erosive wear","volume":"29","author":"Zanatta RF","year":"2021","journal-title":"J Appl Oral Sci"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12903-016-0231-y","article-title":"Does erosion progress differently on teeth already presenting clinical signs of erosive tooth wear than on sound teeth?","volume":"1","author":"Carvalho TS","year":"2017","journal-title":"in vitro pilot trial. 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