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Dent. J."],"abstract":"<jats:p>Abstract This scoping review identified and mapped the adverse reactions and complications associated with the use of hyaluronic acid (HA) dermal fillers in facial aesthetic procedures. This scoping review was reported according to the PRISMA-ScR. Searches were conducted in three electronic databases (PubMed, Scopus, and Web of Science). Randomized clinical trials, cross-sectional studies, retrospective or prospective cohort studies, case series, or case reports published until 2024 that assessed or reported the use of HA for facial filling in healthy adult patients and documented any adverse reaction or complication were included. Study selection was conducted independently by two researchers. Data extraction was performed on half of the included studies by each reviewer, with cross-checking by a third reviewer. A descriptive analysis of the data was performed, considering the different study designs and the complications and adverse reactions reported. Data were presented in tables and graphs. Fifty-five studies met the eligibility criteria and were included. Most studies were case series and case reports (67.3%). Sample sizes ranged from 1 to 5,000, and participant ages ranged from 18 to 78 years. The most reported adverse reactions among the included studies were bruising (56.4%), ischemia (45.4%), and edema (41.81%), with itching less frequent (3.6%). The most severe complications reported were tissue necrosis (29.1%) and tissue embolism (20%), with some cases leading to blindness or stroke. Bruising and ischemia were the most frequently reported adverse reactions, while tissue necrosis was the most common severe complication reported.<\/jats:p>","DOI":"10.1590\/0103-644020266888","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:15:46Z","timestamp":1784898946000},"source":"Crossref","is-referenced-by-count":2,"title":["Adverse reactions and complications caused by hyaluronic acid injections in the face: A scoping review"],"prefix":"10.1590","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7995-1133","authenticated-orcid":false,"given":"Fl\u00e1via Arpini","family":"Ferreto","sequence":"first","affiliation":[{"name":"Graduate Program in Dentistry,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8643-5026","authenticated-orcid":false,"given":"William Vin\u00edcius de Oliveira","family":"Santos","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1514-7879","authenticated-orcid":false,"given":"Rafael","family":"Sarkis-Onofre","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","article-title":"Dermaroller action on dermal hyperchromia: literature review","author":"Souza KM","year":"2017","journal-title":"Health Topics"},{"key":"ref2","article-title":"Comparative evaluation of fractional CO2 laser and dermabrasion in the treatment of acne scars","author":"Rosas FMB","year":"2012","journal-title":"Surg Cosmet Dermatol"},{"key":"ref3","article-title":"Human facial aging and its measurement\u2014the initial step of prosoporrecognography","author":"Filho S","year":"2016","journal-title":"Rev Sodebras"},{"key":"ref4","article-title":"Facial 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complications with hyaluronic acid fillers: a retrospective review of 2088 cases","author":"Harb A","year":"2024","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"ref53","doi-asserted-by":"crossref","DOI":"10.1186\/2047-783X-19-30","article-title":"Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients","author":"Hilton S","year":"2014","journal-title":"Eur J Med Res"},{"key":"ref54","article-title":"Hyaluronic acid filler-induced vascular occlusion: three case reports and overview of prevention and treatment","author":"Wang R","year":"2024","journal-title":"J Cosmet Dermatol"},{"key":"ref55","article-title":"An adverse reaction after hyaluronic acid filler application: a case report","author":"Vidi\u010d M","year":"2018","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"},{"key":"ref56","article-title":"Retrospective study of vascular complications caused by hyaluronic acid injection","author":"Zhang 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