{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:04:57Z","timestamp":1767625497532},"reference-count":37,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20132938","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T12:50:54Z","timestamp":1389185454000},"page":"24-34","source":"Crossref","is-referenced-by-count":11,"title":["RNAi-mediated knockdown of FANCF suppresses cell proliferation, migration, invasion, and drug resistance potential of breast cancer cells"],"prefix":"10.1590","volume":"47","author":[{"given":"L.","family":"Zhao","sequence":"first","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Li","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.K.","family":"Yu","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.T.","family":"Tang","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.L.","family":"Li","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"He","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.J.","family":"Yu","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.F.","family":"Bai","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.H.","family":"Zheng","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.H.","family":"Wang","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Wei","sequence":"additional","affiliation":[{"name":"China Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal A","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.cell.2005.12.009","article-title":"Fanconi anemia (cross)linked to DNA repair","volume":"123","author":"Niedernhofer LJ","year":"2005","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mrfmmm.2009.01.013","article-title":"Fanconi anemia and its diagnosis","volume":"668","author":"Auerbach AD","year":"2009","journal-title":"Mutat Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1056\/NEJMra0809889","article-title":"Susceptibility pathways in Fanconi's anemia and breast cancer","volume":"362","author":"D'Andrea AD","year":"2010","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.33549\/physiolres.932115","article-title":"DNA repair: exploiting the Fanconi anemia pathway as a potential therapeutic target","volume":"60","author":"Hucl T","year":"2011","journal-title":"Physiol Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/ng.570","article-title":"Mutation of the RAD51C gene in a Fanconi anemia-like disorder","volume":"42","author":"Vaz F","year":"2010","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/ng.750","article-title":"Mutations of the SLX4 gene in Fanconi anemia","volume":"43","author":"Kim Y","year":"2011","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/ng.751","article-title":"SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype","volume":"43","author":"Stoepker C","year":"2011","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/sj.emboj.7601574","article-title":"Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability","volume":"26","author":"Bogliolo M","year":"2007","journal-title":"EMBO J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4161\/cc.6.9.4223","article-title":"New roads to FA\/BRCA pathway: H2AX","volume":"6","author":"Lyakhovich A","year":"2007","journal-title":"Cell Cycle"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"39421","DOI":"10.1074\/jbc.M407034200","article-title":"The Fanconi anemia gene product FANCF is a flexible adaptor protein","volume":"279","author":"Leveille F","year":"2004","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/sj.bjc.6604325","article-title":"Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer","volume":"98","author":"Lim SL","year":"2008","journal-title":"Br J Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4161\/cbt.5.3.2380","article-title":"Promoter hypermethylation of FANCF plays an important role in the occurrence of ovarian cancer through disrupting Fanconi anemia-BRCA pathway","volume":"5","author":"Wang Z","year":"2006","journal-title":"Cancer Biol Ther"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1365-2141.2003.04640.x","article-title":"Bi-allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia","volume":"123","author":"Tischkowitz M","year":"2003","journal-title":"Br J Haematol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1158\/0008-5472.CAN-04-0245","article-title":"Promoter hypermethylation of FANCF: disruption of Fanconi anemia-BRCA pathway in cervical cancer","volume":"64","author":"Narayan G","year":"2004","journal-title":"Cancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000108297","article-title":"Disruption of the FA\/BRCA pathway in bladder cancer","volume":"118","author":"Neveling K","year":"2007","journal-title":"Cytogenet Genome Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/sj.onc.1207256","article-title":"Inactivation of the Fanconi anemia\/BRCA pathway in lung and oral cancers: implications for treatment and survival","volume":"23","author":"Marsit CJ","year":"2004","journal-title":"Oncogene"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1535-6108(03)00111-9","article-title":"FANCF methylation contributes to chemoselectivity in ovarian cancer","volume":"3","author":"Olopade OI","year":"2003","journal-title":"Cancer Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1182\/blood-2004-11-4286","article-title":"The FA\/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells","volume":"106","author":"Chen Q","year":"2005","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00109-006-0153-2","article-title":"The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents","volume":"85","author":"Chen CC","year":"2007","journal-title":"J Mol Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12282-009-0175-z","article-title":"Low incidence of methylation of the promoter region of the FANCF gene in Japanese primary breast cancer","volume":"18","author":"Tokunaga E","year":"2011","journal-title":"Breast Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10549-007-9766-6","article-title":"Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers","volume":"111","author":"Wei M","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/1476-4598-9-314","article-title":"Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin","volume":"9","author":"Shukla A","year":"2010","journal-title":"Mol Cancer"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh NP","year":"1988","journal-title":"Exp Cell Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0921-8777(95)00063-1","article-title":"The comet assay: mechanisms and technical considerations","volume":"363","author":"Klaude M","year":"1996","journal-title":"Mutat Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e14546","DOI":"10.1371\/journal.pone.0014546","article-title":"Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells","volume":"6","author":"Ren X","year":"2011","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1074\/jbc.M608356200","article-title":"Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex","volume":"282","author":"Kowal P","year":"2007","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10555-010-9235-2","article-title":"Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals","volume":"29","author":"Gupta SC","year":"2010","journal-title":"Cancer Metastasis Rev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1097-2765(01)00173-3","article-title":"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway","volume":"7","author":"Garcia-Higuera I","year":"2001","journal-title":"Mol Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e44254","DOI":"10.1371\/journal.pone.0044254","article-title":"Gene silencing of FANCF potentiates the sensitivity to mitoxantrone through activation of JNK and p38 signal pathways in breast cancer cells","volume":"7","author":"Li Y","year":"2012","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1016\/j.bmc.2012.09.015","article-title":"The antitumor agent doxorubicin binds to Fanconi anemia group F protein","volume":"20","author":"Kusayanagi T","year":"2012","journal-title":"Bioorg Med Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.dnarep.2010.10.006","article-title":"Physical and functional crosstalk between Fanconi anemia core components and the GINS replication complex","volume":"10","author":"Tumini E","year":"2011","journal-title":"DNA Repair"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1128\/MCB.24.1.123-134.2004","article-title":"Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia\/BRCA pathway","volume":"24","author":"Rothfuss A","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1126\/science.6093249","article-title":"Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II","volume":"226","author":"Tewey KM","year":"1984","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1158\/0008-5472.CAN-05-3410","article-title":"Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death","volume":"66","author":"Swift LP","year":"2006","journal-title":"Cancer Res"},{"key":"ref36","first-page":"8194","article-title":"Molecular basis for the synergistic interaction of adriamycin with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9)","volume":"61","author":"Cutts SM","year":"2001","journal-title":"Cancer Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1200\/JCO.2008.16.0812","article-title":"A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair","volume":"26","author":"Ashworth A","year":"2008","journal-title":"J Clin Oncol"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v47n1\/1414-431X-bjmbr-20132938.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T15:01:12Z","timestamp":1597330872000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2014000100024&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,12]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1]]}},"alternative-id":["S0100-879X2014000100024"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20132938","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12,12]]}}}