{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:18:35Z","timestamp":1777317515471,"version":"3.51.4"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20143935","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T13:13:53Z","timestamp":1404738833000},"page":"637-645","source":"Crossref","is-referenced-by-count":8,"title":["Effect of JJYMD-C, a novel synthetic derivative of gallic acid, on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro"],"prefix":"10.1590","volume":"47","author":[{"given":"G.J.","family":"Xu","sequence":"first","affiliation":[{"name":"Guangxi Medical University,  China; Guangxi Medical University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.H.","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangxi Medical University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangxi University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.W.","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangxi University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangxi Medical University,  China; Guangxi Medical University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangxi Medical University,  China; Guangxi Medical University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2014,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00167-010-1053-0","article-title":"Epidemiology and imaging of the subchondral bone in articular cartilage repair","volume":"18","author":"Menetrey J","year":"2010","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/joca.1999.0309","article-title":"Neochondrogenesis in repair of full-thickness articular cartilage defects using free autogenous periosteal grafts in the rabbit. A follow-up in six months","volume":"8","author":"Carranza-Bencano A","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1053\/joca.2001.0504","article-title":"Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees","volume":"10","author":"Wakitani S","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"ref4","first-page":"477","article-title":"Articular cartilage: tissue design and chondrocyte-matrix interactions","volume":"47","author":"Buckwalter JA","year":"1998","journal-title":"Instr Course Lect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"7236","DOI":"10.1016\/j.actbio.2013.04.003","article-title":"Bi-layer collagen\/microporous electrospun nanofiber scaffold improves the osteochondral regeneration","volume":"9","author":"Zhang S","year":"2013","journal-title":"Acta Biomater"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/jor.20470","article-title":"Repair of large full-thickness articular cartilage defects by transplantation of autologous uncultured bone-marrow-derived mononuclear cells","volume":"26","author":"Chang F","year":"2008","journal-title":"J Orthop Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1007\/s11999-009-0885-8","article-title":"One-step bone marrow-derived cell transplantation in talar osteochondral lesions","volume":"467","author":"Giannini S","year":"2009","journal-title":"Clin Orthop Relat Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.addr.2007.08.027","article-title":"Engineering cartilage tissue","volume":"60","author":"Chung C","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0901-5027(05)80328-5","article-title":"Tissue-engineered growth of cartilage: the effect of varying the concentration of chondrocytes seeded onto synthetic polymer matrices","volume":"23","author":"Puelacher WC","year":"1994","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1067\/mtc.2002.121161","article-title":"Autologous tissue-engineered trachea with sheep nasal chondrocytes","volume":"123","author":"Kojima K","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neuint.2005.10.010","article-title":"Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives","volume":"48","author":"Lu Z","year":"2006","journal-title":"Neurochem Int"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1440-1681.2009.05171.x","article-title":"Effects of sodium ferulate on human osteoarthritic chondrocytes and osteoarthritis in rats","volume":"36","author":"Shang L","year":"2009","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.nutres.2013.02.011","article-title":"Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses","volume":"33","author":"Nobre ME","year":"2013","journal-title":"Nutr Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-2006-961535","article-title":"Anti-inflammatory activity of gallic acid","volume":"58","author":"Kroes BH","year":"1992","journal-title":"Planta Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.foodchem.2012.08.009","article-title":"Toona sinensis and its major bioactive compound gallic acid inhibit LPS-induced inflammation in nuclear factor-kappaB transgenic mice as evaluated by in vivo bioluminescence imaging","volume":"136","author":"Hsiang CY","year":"2013","journal-title":"Food Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jbspin.2012.08.010","article-title":"Gallic acid, a natural polyphenolic acid, induces apoptosis and inhibits proinflammatory gene expressions in rheumatoid arthritis fibroblast-like synoviocytes","volume":"80","author":"Yoon CH","year":"2013","journal-title":"Joint Bone Spine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cyto.2009.11.003","article-title":"Transcriptional regulation of cytokines and oxidative stress by gallic acid in human THP-1 monocytes","volume":"49","author":"Kuppan G","year":"2010","journal-title":"Cytokine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1002\/mnfr.201100262","article-title":"Gallic acid, a histone acetyltransferase inhibitor, suppresses beta-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation","volume":"55","author":"Kim MJ","year":"2011","journal-title":"Mol Nutr Food Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.2174\/09298673113209990175","article-title":"Gallic acid attenuates oleic acid-induced proliferation of vascular smooth muscle cell through regulation of AMPK-eNOS-FAS signaling","volume":"20","author":"Ou TT","year":"2013","journal-title":"Curr Med Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1021\/jm900261f","article-title":"N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis","volume":"52","author":"Nuti E","year":"2009","journal-title":"J Med Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/CMR.0b013e3283414444","article-title":"Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras","volume":"21","author":"Lo C","year":"2011","journal-title":"Melanoma Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.fct.2010.06.024","article-title":"Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K\/AKT\/small GTPase signals","volume":"48","author":"Ho HH","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.fct.2014.01.017","article-title":"Topical application of Gallic acid suppresses the 7,12-DMBA\/Croton oil induced two-step skin carcinogenesis by modulating anti-oxidants and MMP-2\/MMP-9 in Swiss albino mice","volume":"66","author":"Subramanian V","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/01635581.2014.851714","article-title":"Gallic acid is an active component for the anticarcinogenic action of grape seed procyanidins in pancreatic cancer cells","volume":"66","author":"Cedo L","year":"2014","journal-title":"Nutr Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jss.2013.11.1088","article-title":"Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediated protection against ischemia-reperfusion-induced acute kidney injury in rats","volume":"187","author":"Singh JP","year":"2014","journal-title":"J Surg Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s12275-009-0097-7","article-title":"Effects of methyl gallate and gallic acid on the production of inflammatory mediators interleukin-6 and interleukin-8 by oral epithelial cells stimulated with Fusobacterium nucleatum","volume":"47","author":"Kang MS","year":"2009","journal-title":"J Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1016\/j.msec.2013.07.024","article-title":"Boron nitride nanotubes coated with organic hydrophilic agents: stability and cytocompatibility studies","volume":"33","author":"Ferreira TH","year":"2013","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3727\/000000001783986882","article-title":"Characteristics of cartilage biopsies used for autologous chondrocytes transplantation","volume":"10","author":"Robinson D","year":"2001","journal-title":"Cell Transplant"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.joca.2004.10.011","article-title":"Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes","volume":"13","author":"Tew SR","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jconrel.2007.11.006","article-title":"Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells","volume":"127","author":"Uebersax L","year":"2008","journal-title":"J Control Release"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/joca.2001.0482","article-title":"Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture","volume":"10","author":"Schnabel M","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"ref32","first-page":"165","article-title":"[Taurine inhibits deposition of extracellular matrix in experimental liver fibrosis in rats]","volume":"7","author":"Chen Y","year":"1999","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"ref33","first-page":"591","article-title":"[Effects of taurine on proliferation of rat cardiac fibroblast]","volume":"43","author":"Ren K","year":"2008","journal-title":"Yao Xue Xue Bao"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0092-8674(82)90027-7","article-title":"Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels","volume":"30","author":"Benya PD","year":"1982","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/ten.tec.2010.0200","article-title":"Human primary articular chondrocytes, chondroblasts-like cells, and dedifferentiated chondrocytes: differences in gene, microRNA, and protein expression and phenotype","volume":"17","author":"Karlsen TA","year":"2011","journal-title":"Tissue Eng Part C Methods"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.136.2.459","article-title":"Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function","volume":"136","author":"Kwan KM","year":"1997","journal-title":"J Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/jn\/132.3.341","article-title":"Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro","volume":"132","author":"Adcocks C","year":"2002","journal-title":"J Nutr"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1046\/j.1432-1033.2003.03607.x","article-title":"Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters","volume":"270","author":"Vankemmelbeke MN","year":"2003","journal-title":"Eur J Biochem"},{"key":"ref39","first-page":"1958","article-title":"Comparative effects of 2 antioxidants, selenomethionine and epigallocatechin-gallate, on catabolic and anabolic gene expression of articular chondrocytes","volume":"32","author":"Andriamanalijaona R","year":"2005","journal-title":"J Rheumatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1186\/ar3368","article-title":"Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes","volume":"13","author":"Akhtar N","year":"2011","journal-title":"Arthritis Res Ther"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v47n8\/1414-431X-bjmbr-1414-431X20143935.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T14:57:35Z","timestamp":1581087455000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2014000800637&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8]]}},"alternative-id":["S0100-879X2014000800637"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20143935","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}