{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:34:53Z","timestamp":1785818093268,"version":"3.56.0"},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20144129","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T12:23:50Z","timestamp":1415795030000},"page":"146-153","source":"Crossref","is-referenced-by-count":19,"title":["Measurement of serum estrogen and estrogen metabolites in pre- and postmenopausal women with osteoarthritis using high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry"],"prefix":"10.1590","volume":"48","author":[{"given":"W.L.","family":"Gao","sequence":"first","affiliation":[{"name":"Linyi People's Hospital of Shandong Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.S.","family":"Wu","sequence":"additional","affiliation":[{"name":"Linyi People's Hospital of Shandong Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.","family":"Zi","sequence":"additional","affiliation":[{"name":"Linyi People's Hospital of Shandong Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wu","sequence":"additional","affiliation":[{"name":"Linyi People's Hospital of Shandong Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.Z.","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Institute for Drug Control,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.C.","family":"Song","sequence":"additional","affiliation":[{"name":"the Third Affiliated Hospital of Southern Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.Z.","family":"Cai","sequence":"additional","affiliation":[{"name":"the Third Affiliated Hospital of Southern Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2015,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/carcin\/21.3.427","article-title":"Hormonal carcinogenesis","volume":"21","author":"Henderson BE","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref2","first-page":"63","article-title":"Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention","volume":"1766","author":"Cavalieri E","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1210\/jcem.82.4.3875","article-title":"Altered hydroxylation of estrogen in patients with postmenopausal osteopenia","volume":"82","author":"Lim SK","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","first-page":"S444","article-title":"Increased inactive estrogen metabolites in urine of early postmenopausal women with low bone density","volume":"10","author":"Hodge J","year":"1995","journal-title":"J Bone Miner Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1002\/art.22005","article-title":"Estradiol and its metabolites and their association with knee osteoarthritis","volume":"54","author":"Sowers MR","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.ph.45.030183.000425","article-title":"Aromatic hydroxylation of estrogens","volume":"45","author":"Fishman J","year":"1983","journal-title":"Annu Rev Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1677\/joe.0.1700165","article-title":"Tissue-selective effects of continuous release of 2-hydroxyestrone and 16alpha-hydroxyestrone on bone, uterus and mammary gland in ovariectomized growing rats","volume":"170","author":"Lotinun S","year":"2001","journal-title":"J Endocrinol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1359\/jbmr.2000.15.3.499","article-title":"Direct action of naturally occurring estrogen metabolites on human osteoblastic cells","volume":"15","author":"Robinson JA","year":"2000","journal-title":"J Bone Miner Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000123569","article-title":"Anovulation in female rats induced by neonatal administration of the catechol estrogens, 2-hydroxy-estradiol and 4-hydroxy-estradiol","volume":"37","author":"MacLusky NJ","year":"1983","journal-title":"Neuroendocrinology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0026-0495(96)90212-7","article-title":"Superior and distinct antioxidant effects of selected estrogen metabolites on lipid peroxidation","volume":"45","author":"Tang M","year":"1996","journal-title":"Metabolism"},{"key":"ref11","first-page":"24","article-title":"[A technic for the determination of ethinyl estradiol and norgestrel]","volume":"47","author":"Szabo A","year":"1977","journal-title":"Acta Pharm Hung"},{"key":"ref12","first-page":"287","article-title":"[Detection of estrogen residues in meat by thin layer chromatography and fluorimetry (author's transl)]","volume":"166","author":"Stan HJ","year":"1978","journal-title":"Z Lebensm Unters Forsch"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1248\/cpb.37.1561","article-title":"Radioimmunoassay of 2-hydroxyesterone using antisera raised against antigenic complexes obtained by convenient methods","volume":"37","author":"Numazawa M","year":"1989","journal-title":"Chem Pharm Bull"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/clinchem\/40.1.80","article-title":"Radioimmunoassay of 2-hydroxyestrone in urine","volume":"40","author":"McGuinness BJ","year":"1994","journal-title":"Clin Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0039-128X(98)00041-5","article-title":"Application of an improved ELISA assay to the analysis of urinary estrogen metabolites","volume":"63","author":"Bradlow HL","year":"1998","journal-title":"Steroids"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0022-4731(74)90134-4","article-title":"Mass fragmentographic determination of eleven estrogens in the body fluids of pregnant and nonpregnant subjects","volume":"5","author":"Adlercreutz H","year":"1974","journal-title":"J Steroid Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/s00216-006-0371-z","article-title":"Procedure for increasing the detection responses of estrogens in LC-MS based on introduction of a nitrobenzene moiety followed by electron capture atmospheric pressure chemical ionization","volume":"386","author":"Higashi T","year":"2006","journal-title":"Anal Bioanal Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7813","DOI":"10.1021\/ac070494j","article-title":"Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry","volume":"79","author":"Xu X","year":"2007","journal-title":"Anal Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.steroids.2010.10.010","article-title":"Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry","volume":"76","author":"Rothman MS","year":"2011","journal-title":"Steroids"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jchromb.2011.08.027","article-title":"The coming of age of liquid chromatography coupled to tandem mass spectrometry in the endocrinology laboratory","volume":"883-884","author":"Carvalho VM","year":"2012","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref21","first-page":"3747","article-title":"[Study on intervention effect of Jieduquyuziyin prescription systemic lupus erythematosus by HPLC-Q-TOF\/MS]","volume":"38","author":"Hu JB","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman R","year":"1986","journal-title":"Arthritis Rheum"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/joca.2002.0840","article-title":"The natural history of emergent osteoarthritis of the knee in women","volume":"10","author":"Lachance L","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/jama.1925.02660280001001","article-title":"Arthritis of the menopause","volume":"84","author":"Cecil RL","year":"1925","journal-title":"J Am Med Assoc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-5122(00)00118-3","article-title":"Menopause, oestrogens and arthritis","volume":"35","author":"Wluka AE","year":"2000","journal-title":"Maturitas"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/joca.1999.0260","article-title":"Expression of genes for estrogen receptors alpha and beta in human articular chondrocytes","volume":"7","author":"Ushiyama T","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1210\/jc.2005-2378","article-title":"Comparison of methods to measure low serum estradiol levels in postmenopausal women","volume":"91","author":"Lee JS","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1158\/1055-9965.EPI-10-0081","article-title":"Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies","volume":"19","author":"Stanczyk FZ","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1309\/5N2R4HT4GM0AGPBY","article-title":"Performance characteristics of eight estradiol immunoassays","volume":"122","author":"Yang DT","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2193-1801-2-5","article-title":"Deficiencies in immunoassay methods used to monitor serum Estradiol levels during aromatase inhibitor treatment in postmenopausal breast cancer patients","volume":"2","author":"Jaque J","year":"2013","journal-title":"Springerplus"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1210\/jc.2012-3780","article-title":"Challenges to the measurement of estradiol: an endocrine society position statement","volume":"98","author":"Rosner W","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jsbmb.2010.05.001","article-title":"Advantages and challenges of mass spectrometry assays for steroid hormones","volume":"121","author":"Stanczyk FZ","year":"2010","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jsbmb.2010.04.010","article-title":"Gas chromatography\/mass spectrometry (GC\/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC\/MS\/MS)","volume":"121","author":"Krone N","year":"2010","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clinbiochem.2010.07.008","article-title":"Liquid chromatography tandem mass spectrometry for analysis of steroids in clinical laboratories","volume":"44","author":"Kushnir MM","year":"2011","journal-title":"Clin Biochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.steroids.2007.05.003","article-title":"Superiority of gas chromatography\/tandem mass spectrometry assay (GC\/MS\/MS) for estradiol for monitoring of aromatase inhibitor therapy","volume":"72","author":"Santen RJ","year":"2007","journal-title":"Steroids"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2166\/wh.2013.021","article-title":"Development and validation of a GC-MS method for the evaluation of 17 endocrine disruptor compounds, including phytoestrogens and sitosterol, in coastal waters - their spatial and seasonal levels in Porto costal region (Portugal)","volume":"11","author":"Rocha MJ","year":"2013","journal-title":"J Water Health"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S1570-0232(03)00331-3","article-title":"Determination using liquid-chromatography-electrospray tandem mass spectroscopy of ethinylestradiol serum pharmacokinetics in adult Sprague-Dawley rats","volume":"793","author":"Twaddle NC","year":"2003","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref38","first-page":"1267","article-title":"[Double isotope method - with special reference to estrogen (sulfonylating reagent 35S method)]","volume":"29","author":"Aizawa Y","year":"1971","journal-title":"Nihon Rinsho"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v48n2\/1414-431X-bjmbr-1414-431X20144129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T08:22:07Z","timestamp":1581409327000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2015000200146&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2]]}},"alternative-id":["S0100-879X2015000200146"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20144129","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}