{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:43:07Z","timestamp":1793752987440,"version":"4.6.1"},"reference-count":35,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"published-print":{"date-parts":[[2016]]},"DOI":"10.1590\/1414-431x20154646","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T17:23:55Z","timestamp":1455989035000},"source":"Crossref","is-referenced-by-count":61,"title":["Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass"],"prefix":"10.1590","volume":"49","author":[{"given":"N.M.H.","family":"Bulow","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Maria,  Brasil; Universidade Federal de Santa Maria,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Colpo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria,  Brasil; Centro Universit\u00e1rio Franciscano,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.P.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Ponta Grossa,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.F.M.","family":"Correa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria,  Brasil; Universidade Federal de Santa Maria,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.P.","family":"Waczuk","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.B.T.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1213\/01.ane.0000215998.21739.48","article-title":"Increased interleukin-6 after cardiac surgery predicts infection","volume":"102","author":"Sander M","year":"2006","journal-title":"Anesth Analg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/1089253210378177","article-title":"Panvascular inflammation and mechanisms of injury in perioperative CNS outcomes","volume":"14","author":"Murkin JM","year":"2010","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1378\/chest.112.3.676","article-title":"Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies","volume":"112","author":"Wan S","year":"1997","journal-title":"Chest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0003-4975(99)01420-4","article-title":"Off-pump bypass graft operation significantly reduces oxidative stress and inflammation","volume":"69","author":"Matata BM","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1053\/j.jvca.2012.09.013","article-title":"Identification of inflammatory mediators and their modulation by strategies for the management of the systemic inflammatory response during cardiac surgery","volume":"27","author":"Hall R","year":"2015","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/jama.1996.03540040044031","article-title":"Atrial fibrillation following coronary artery bypass graft surgery: predictors, outcomes, and resource utilization. MultiCenter Study of Perioperative Ischemia Research Group","volume":"276","author":"Mathew JP","year":"1996","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1056\/NEJMp020171","article-title":"Off-pump coronary-artery bypass surgery","volume":"348","author":"Rose EA","year":"2003","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.nut.2013.10.026","article-title":"Massive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation","volume":"30","author":"Rodemeister S","year":"2014","journal-title":"Nutrition"},{"key":"ref9","article-title":"Inflammatory response in patients under coronary artery bypass grafting surgery and clinical implications: a review of the relevance of dexmedetomidine use","author":"Bulow NMH","year":"2014","journal-title":"ISRN Anesthesiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1017\/S0265021506000378","article-title":"Perioperative use of alpha2-adrenoceptor agonists and the cardiac patient","volume":"23","author":"Aantaa R","year":"2006","journal-title":"Eur J Anaesthesiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/bja\/ael270","article-title":"The effects of propofol on neutrophil function, lipid peroxidation and inflammatory response during elective coronary artery bypass grafting in patients with impaired ventricular function","volume":"97","author":"Corcoran TB","year":"2006","journal-title":"Br J Anaesth"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/bja\/aem017","article-title":"Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients","volume":"98","author":"Memis D","year":"2007","journal-title":"Br J Anaesth"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1213\/00000539-200108000-00026","article-title":"Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-alpha during the perioperative period","volume":"93","author":"Nader ND","year":"2001","journal-title":"Anesth Analg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/bja\/aet194","article-title":"Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients: a systematic review","volume":"111","author":"Adams R","year":"2013","journal-title":"Br J Anaesth"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/bja\/aet066","article-title":"Facilitatory effects of perineural dexmedetomidine on neuraxial and peripheral nerve block: a systematic review and meta-analysis","volume":"110","author":"Abdallah FW","year":"2013","journal-title":"Br J Anaesth"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1213\/ane.0b013e3181ae0856","article-title":"Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial","volume":"110","author":"Candiotti KA","year":"2010","journal-title":"Anesth Analg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1399-6576.2009.02019.x","article-title":"Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury","volume":"53","author":"Can M","year":"2009","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1399-6576.2011.02526.x","article-title":"Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice","volume":"55","author":"Gu J","year":"2011","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/j.1365-2044.2012.07334.x","article-title":"All hands on dex","volume":"67","author":"Sleigh J","year":"2012","journal-title":"Anaesthesia"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1590\/S0100-40422009000100032","article-title":"Importance of the lipid peroxidation biomarkers and methodological aspects for malondialdehyde quantification","volume":"32","author":"Grotto D","year":"2009","journal-title":"Quimica Nova"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1039\/c2tx20014g","article-title":"Aminolevulinate dehydratase (\u03b4-ALA-D) as marker protein of intoxication with metals and other pro-oxidant situations","volume":"1","author":"Rocha JBT","year":"2012","journal-title":"Toxicol Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/0960327110372399","article-title":"Dexmedetomidine protects blood \u03b4-minolevulinate dehydratase from inactivation caused by hyperoxygenation in total intravenous anesthesia","volume":"30","author":"Rocha JBT","year":"2011","journal-title":"Hum Exp Tox"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1046\/j.1471-4159.1997.68041633.x","article-title":"Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control","volume":"68","author":"Straub RH","year":"1997","journal-title":"J Neurochem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/TA.0b013e31827d5de3","article-title":"Protective effects of dexmedetomidine on blunt chest trauma-induced pulmonary contusion in rats","volume":"74","author":"Wu X","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/01.CCM.0000128579.84228.2A","article-title":"Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats","volume":"32","author":"Taniguchi T","year":"2004","journal-title":"Crit Care Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00540-008-0611-9","article-title":"Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats","volume":"22","author":"Taniguchi T","year":"2008","journal-title":"J Anesth"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jss.2008.07.010","article-title":"Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages","volume":"154","author":"Lai YC","year":"2009","journal-title":"J Surg Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0165-5728(99)00234-9","article-title":"Differential involvement of sympathetic nervous system and immune system in the modulation of TNF-alpha production by alpha2- and beta-adrenoceptors in mice","volume":"103","author":"Szelenyi J","year":"2000","journal-title":"J Neuroimmunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/cc7709","article-title":"Central sympatholytics prolong survival in experimental sepsis","volume":"13","author":"Hofer S","year":"2009","journal-title":"Crit Care"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jclinane.2008.10.010","article-title":"Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis","volume":"21","author":"Tasdogan M","year":"2009","journal-title":"J Clin Anesth"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1016\/j.jss.2012.05.047","article-title":"Dexmedetomidine attenuates lipopolysaccharide-induced proinflammatory response in primary microglia","volume":"179","author":"Peng M","year":"2013","journal-title":"J Surg Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1213\/00000539-199108000-00015","article-title":"Effects of dexmedetomidine, a novel imidazole sedative-anesthetic agent, on adrenal steroidogenesis: in vivo and in vitro studies","volume":"73","author":"Maze M","year":"1991","journal-title":"Anesth Analg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/bja\/86.5.650","article-title":"Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit","volume":"86","author":"Venn RM","year":"2001","journal-title":"Br J Anaesth"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jclinane.2007.01.004","article-title":"Opioid consumption in total intravenous anesthesia is reduced with dexmedetomidine: a comparative study with remifentanil in gynecologic videolaparoscopic surgery","volume":"19","author":"Bulow NM","year":"2007","journal-title":"J Clin Anesth"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/ANA.0b013e31826318af","article-title":"The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery","volume":"25","author":"Bekker A","year":"2013","journal-title":"J Neurosurg Anesthesiol"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v49n4\/1414-431X-bjmbr-1414-431X20154646.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T07:11:49Z","timestamp":1495523509000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2016000400702&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"alternative-id":["S0100-879X2016000400702"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20154646","relation":{},"ISSN":["0100-879X"],"issn-type":[{"value":"0100-879X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}