{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:56:23Z","timestamp":1790265383622,"version":"4.1.0"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"published-print":{"date-parts":[[2016]]},"DOI":"10.1590\/1414-431x20155031","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T17:23:54Z","timestamp":1455989034000},"source":"Crossref","is-referenced-by-count":22,"title":["Montelukast reduces seizures in pentylenetetrazol-kindled mice"],"prefix":"10.1590","volume":"49","author":[{"given":"J.","family":"Fleck","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Maria, Brasil; Universidade Federal de Santa Maria, Brasil; Centro Universit\u00e1rio Franciscano, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.R.","family":"Temp","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Marafiga","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.","family":"Jesse","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.H.","family":"Milanesi","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.M.","family":"Rambo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.F.","family":"Mello","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/epi.12585","article-title":"Final comments on the process: ILAE definition of epilepsy","volume":"55","author":"Fisher RS","year":"2014","journal-title":"Epilepsia"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1528-1167.2005.54904.x","article-title":"Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms","volume":"46","author":"Schmidt D","year":"2005","journal-title":"Epilepsia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1111\/j.1528-1167.2005.00298.x","article-title":"Brain inflammation in epilepsy: experimental and clinical evidence","volume":"46","author":"Vezzani A","year":"2005","journal-title":"Epilepsia"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"901902","DOI":"10.1155\/2014\/901902","article-title":"Role of inflammatory mediators in the pathogenesis of epilepsy","volume":"2014","author":"Shimada T","year":"2014","journal-title":"Mediators Inflamm"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresrev.2006.02.002","article-title":"Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders","volume":"52","author":"Phillis JW","year":"2006","journal-title":"Brain Res Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1528-1157.1988.tb03724.x","article-title":"Increased concentration of prostaglandin E-2 in cerebrospinal fluid of children with febrile convulsions","volume":"29","author":"Loscher W","year":"1988","journal-title":"Epilepsia"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0887-8994(96)83272-3","article-title":"Leukotriene B4 and C4 in cerebrospinal fluid from children with meningitis and febrile seizures","volume":"14","author":"Matsuo M","year":"1996","journal-title":"Pediatr Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0006-8993(90)90579-Z","article-title":"Cysteinyl-leukotriene production during limbic seizures triggered by kainic acid","volume":"515","author":"Simmet T","year":"1990","journal-title":"Brain Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.plefa.2011.04.003","article-title":"Modulation of leukotriene D4 attenuates the development of seizures in mice","volume":"85","author":"Rehni AK","year":"2011","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuroscience.2014.07.058","article-title":"Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction","volume":"277","author":"Lenz QF","year":"2014","journal-title":"Neuroscience"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.phrs.2015.02.001","article-title":"Montelukast potentiates the anticonvulsant effect of phenobarbital in mice: an isobolographic analysis","volume":"94","author":"Fleck J","year":"2015","journal-title":"Pharmacol Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"869","DOI":"10.12659\/MSM.892932","article-title":"Montelukast inhibits pentylenetetrazol-induced seizures in rats","volume":"21","author":"Cevik B","year":"2015","journal-title":"Med Sci Monit"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.pnpbp.2006.05.013","article-title":"Pentylenetetrazol-induced kindling seizure attenuated by Ginkgo biloba extract (EGb 761) in mice","volume":"30","author":"Ilhan A","year":"2006","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1523\/JNEUROSCI.19-16-06733.1999","article-title":"Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice","volume":"19","author":"Ferraro TN","year":"1999","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.nlm.2011.06.007","article-title":"Hippocampal PKA\/CREB pathway is involved in the improvement of memory induced by spermidine in rats","volume":"96","author":"Guerra GP","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S1043-6618(05)80093-3","article-title":"Lipoxygenase products of polyunsaturated fatty acid metabolism in the central nervous system: biosynthesis and putative functions","volume":"22","author":"Simmet T","year":"1990","journal-title":"Pharmacol Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1111\/j.1471-4159.2007.04830.x","article-title":"Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells","volume":"103","author":"Farias SE","year":"2007","journal-title":"J Neurochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/awl318","article-title":"Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy","volume":"130","author":"Van Vliet EA","year":"2007","journal-title":"Brain"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/glia.22311","article-title":"Blood-brain barrier dysfunction, TGFbeta signaling, and astrocyte dysfunction in epilepsy","volume":"60","author":"Heinemann U","year":"2012","journal-title":"Glia"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.semcdb.2014.10.003","article-title":"Blood-brain barrier dysfunction, seizures and epilepsy","volume":"38","author":"Van Vliet EA","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0022-510X(83)90016-3","article-title":"Regional patterns of blood-brain barrier breakdown during epileptiform seizures induced by various convulsive agents","volume":"59","author":"Nitsch C","year":"1983","journal-title":"J Neurol Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainres.2009.05.033","article-title":"Levetiracetam decreases the seizure activity and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia","volume":"1281","author":"Gurses C","year":"2009","journal-title":"Brain Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000312669","article-title":"Cysteinyl leukotrienes and their receptors: molecular and functional characteristics","volume":"85","author":"Singh RK","year":"2010","journal-title":"Pharmacology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.6301011","article-title":"Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation","volume":"220","author":"Samuelsson B","year":"1983","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11064-014-1478-9","article-title":"Montelukast, a cysteinyl leukotriene receptor-1 antagonist protects against hippocampal injury induced by transient global cerebral ischemia and reperfusion in rats","volume":"40","author":"Saad MA","year":"2015","journal-title":"Neurochem Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.expneurol.2014.03.008","article-title":"Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits","volume":"256","author":"Corser-Jensen CE","year":"2014","journal-title":"Exp Neurol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1089\/neu.2009.0877","article-title":"Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury","volume":"26","author":"Farias S","year":"2009","journal-title":"J Neurotrauma"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/neu.1996.13.781","article-title":"Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats","volume":"13","author":"Dhillon HS","year":"1996","journal-title":"J Neurotrauma"},{"key":"ref29","article-title":"Methods for treating or preventing brain infections.","author":"Kim KS","year":"2009","journal-title":"International application published under the patent cooperation treaty (pct)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0022-3565(25)32765-5","article-title":"Electrophysiological response of cerebellar Purkinje neurons to leukotriene D4 and B4","volume":"219","author":"Palmer MR","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"ref31","first-page":"97","article-title":"Montelukast in paediatric asthma: where we are now and what still needs to be done?","volume":"16","author":"Bush A","year":"2015","journal-title":"Paediatr Respir Rev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.braindev.2012.04.001","article-title":"Open study of pranlukast add-on therapy in intractable partial epilepsy","volume":"35","author":"Takahashi Y","year":"2013","journal-title":"Brain Dev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1124\/jpet.103.059824","article-title":"Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1","volume":"309","author":"Dupr\u00e9 DJ","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.neuro.27.070203.144206","article-title":"Desensitization of G protein-coupled receptors and neuronal functions","volume":"27","author":"Gainetdinov RR","year":"2004","journal-title":"Annu Rev Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1124\/mol.60.5.1064","article-title":"Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat mu-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation","volume":"60","author":"Li J","year":"2001","journal-title":"Mol Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10072-013-1552-0","article-title":"Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice","volume":"35","author":"Ahmadirad N","year":"2014","journal-title":"Neurol Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0006-8993(98)00864-6","article-title":"Effects of GABAB receptor antagonism on the development of pentylenetetrazol-induced kindling in mice","volume":"809","author":"Getova D","year":"1998","journal-title":"Brain Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0091-3057(01)00612-8","article-title":"Morphological alterations of neurons and astrocytes and changes in emotional behavior in pentylenetetrazol-kindled rats","volume":"70","author":"Franke H","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0006-8993(92)91316-7","article-title":"Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization","volume":"593","author":"Golarai G","year":"1992","journal-title":"Brain Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuroscience.2004.04.014","article-title":"Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy","volume":"126","author":"Cavazos JE","year":"2004","journal-title":"Neuroscience"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v49n4\/1414-431X-bjmbr-1414-431X20155031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T09:11:54Z","timestamp":1748769114000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2016000400602&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"alternative-id":["S0100-879X2016000400602"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20155031","relation":{},"ISSN":["0100-879X"],"issn-type":[{"value":"0100-879X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}