{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:55:41Z","timestamp":1792079741985,"version":"4.4.0"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20176049","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T18:18:02Z","timestamp":1494958682000},"source":"Crossref","is-referenced-by-count":7,"title":["Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice"],"prefix":"10.1590","volume":"50","author":[{"given":"Y.L.","family":"Jia","sequence":"first","affiliation":[{"name":"Zhengzhou University,  China; Central Hospital of Kaifeng,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.X.","family":"Fu","sequence":"additional","affiliation":[{"name":"Central Hospital of Kaifeng,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Hospital of Kaifeng,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.J.","family":"Jia","sequence":"additional","affiliation":[{"name":"Zhengzhou University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2017]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/geno.1998.5335","article-title":"10 years of Genomics, chromosome 21, and Down syndrome","volume":"51","author":"Antonarakis SE","year":"1998","journal-title":"Genomics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neulet.2011.01.028","article-title":"Expression and significance of DSCAM in the cerebral cortex of APP transgenic mice","volume":"491","author":"Jia YL","year":"2011","journal-title":"Neurosci Lett"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nn.3396","article-title":"Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting","volume":"16","author":"Cvetkovska V","year":"2013","journal-title":"Nat Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"16637","DOI":"10.1523\/JNEUROSCI.2811-12.2012","article-title":"DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex","volume":"32","author":"Maynard KR","year":"2012","journal-title":"J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.bi.60.070191.001103","article-title":"Cell adhesion molecules: implications for a molecular histology","volume":"60","author":"Edelman GM","year":"1991","journal-title":"Annu Rev Biochem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/hmg\/7.2.227","article-title":"DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system","volume":"7","author":"Yamakawa K","year":"1998","journal-title":"Hum Mol Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nn1652","article-title":"Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe","volume":"9","author":"Zhu H","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1523\/JNEUROSCI.1517-07.2007","article-title":"Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization","volume":"27","author":"Shi L","year":"2007","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.cell.2004.08.021","article-title":"Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding","volume":"118","author":"Wojtowicz WM","year":"2004","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0896-6273(02)00570-6","article-title":"Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons","volume":"33","author":"Wang J","year":"2002","journal-title":"Neuron"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0896-6273(02)01183-2","article-title":"Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam","volume":"37","author":"Hummel T","year":"2003","journal-title":"Neuron"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.cell.2007.08.026","article-title":"A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains","volume":"130","author":"Wojtowicz WM","year":"2007","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1074\/jbc.274.10.6483","article-title":"Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain","volume":"274","author":"Moechars D","year":"1999","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000048808","article-title":"Down syndrome cell adhesion molecule is conserved in mouse and highly expressed in the adult mouse brain","volume":"94","author":"Barlow GM","year":"2001","journal-title":"Cytogenet Cell Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuron.2009.01.010","article-title":"Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation","volume":"61","author":"Li HL","year":"2009","journal-title":"Neuron"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s004010000230","article-title":"The developmental and aging changes of Down's syndrome cell adhesion molecule expression in normal and Down's syndrome brains","volume":"100","author":"Saito Y","year":"2000","journal-title":"Acta Neuropathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0896-6273(00)00033-7","article-title":"Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance","volume":"27","author":"Castellani V","year":"2000","journal-title":"Neuron"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0896-6273(00)00025-8","article-title":"Crossed wires: L1 and neuropilin interactions","volume":"27","author":"He Z","year":"2000","journal-title":"Neuron"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0092-8674(00)00041-6","article-title":"Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord","volume":"102","author":"Zou Y","year":"2000","journal-title":"Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1126\/science.1059391","article-title":"Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation","volume":"291","author":"Stein E","year":"2001","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2006.03.034","article-title":"The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila","volume":"125","author":"Chen BE","year":"2006","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.conb.2008.05.005","article-title":"Dscam-mediated repulsion controls tiling and self-avoidance","volume":"18","author":"Millard SS","year":"2008","journal-title":"Curr Opin Neurobiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/ana.410430316","article-title":"Molecular mapping of Alzheimer-type dementia in Down's syndrome","volume":"43","author":"Prasher VP","year":"1998","journal-title":"Ann Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0092-8674(00)80878-8","article-title":"Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity","volume":"101","author":"Schmucker D","year":"2000","journal-title":"Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0896-6273(00)80197-X","article-title":"Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth","volume":"17","author":"Schuster CM","year":"1996","journal-title":"Neuron"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0169-328X(00)00108-X","article-title":"Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion","volume":"79","author":"Agarwala KL","year":"2000","journal-title":"Brain Res Mol Brain Res"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v50n6\/1414-431X-bjmbr-1414-431X20176049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T15:48:46Z","timestamp":1581090526000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2017000600603&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017]]}},"alternative-id":["S0100-879X2017000600603"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20176049","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]},"article-number":"e6049"}}