{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:52:16Z","timestamp":1771066336146,"version":"3.50.1"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","issue":"10","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20176586","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T15:40:04Z","timestamp":1502898004000},"source":"Crossref","is-referenced-by-count":20,"title":["Antiviral activity of shikonin ester derivative PMM-034 against enterovirus 71 in vitro"],"prefix":"10.1590","volume":"50","author":[{"given":"Y.","family":"Zhang","sequence":"first","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China; Suzhou Industrial Park Center for Disease Control and Prevention,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Han","sequence":"additional","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Agriculture, Nanjing Agricultural University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Qiu","sequence":"additional","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lin","sequence":"additional","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Yu","sequence":"additional","affiliation":[{"name":"Suzhou Industrial Park Center for Disease Control and Prevention,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Suzhou Industrial Park Center for Disease Control and Prevention,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Qi","sequence":"additional","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Yang","sequence":"additional","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Pang","sequence":"additional","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lu","sequence":"additional","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.clnu.2011.12.005","article-title":"Influence of vitamin A status on the antiviral immunity of children with hand, foot and mouth disease","volume":"31","author":"Chen S","year":"2012","journal-title":"Clin Nutr"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ajpath.2013.11.009","article-title":"Tonsillar crypt epithelium is an important extra-central nervous system site for viral replication in EV71 encephalomyelitis","volume":"184","author":"He Y","year":"2014","journal-title":"Am J Pathol"},{"key":"ref3","first-page":"R725.721","article-title":"Research progress on the pathogenesis of EV71-induced neurogenic pulmonary edema","volume":"1","author":"Yu ZL","year":"2013","journal-title":"Hn Jornal of Mroology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev-pharmtox-010716-104533","article-title":"Accelerating drug development: antiviral therapies for emerging viruses as a model","volume":"57","author":"Everts M","year":"2017","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.4065\/mcp.2011.0309","article-title":"Antiviral drugs for viruses other than human immunodeficiency virus","volume":"86","author":"Razonable RR","year":"2011","journal-title":"Mayo Clin Proc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1471-2334-12-224","article-title":"Excessive proinflammatory cytokine and chemokine responses of human monocyte-derived macrophages to enterovirus 71 infection","volume":"12","author":"Gong X","year":"2012","journal-title":"BMC Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.virusres.2014.12.016","article-title":"Regulation of host responses and viral replication by the mitogen-activated protein kinases in intestinal epithelial cells infected with Enterovirus 71","volume":"197","author":"Wang C","year":"2015","journal-title":"Virus Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e111496","DOI":"10.1371\/journal.pone.0111496","article-title":"Enterovirus-71 virus-like particles induce the activation and maturation of human monocyte-derived dendritic cells through TLR4 signaling","volume":"9","author":"Lin YL","year":"2014","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jep.2016.03.034","article-title":"Gan-Lu-Siao-Du-yin, a prescription of traditional Chinese medicine, inhibited enterovirus 71 replication, translation, and virus-induced cell apoptosis.","volume":"185","author":"Hsieh YJ","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.phymed.2016.08.001","article-title":"Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication","volume":"23","author":"Esposito F","year":"2016","journal-title":"Phytomedicine"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1248\/bpb.b14-00357","article-title":"Antiviral activity of Paulownia tomentosa against enterovirus 71 of hand, foot, and mouth disease","volume":"38","author":"Ji P","year":"2015","journal-title":"Biol Pharm Bull"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/cbdd.12077","article-title":"Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives","volume":"81","author":"Lin HY","year":"2013","journal-title":"Chem Biol Drug Des"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/jssc.201600087","article-title":"Rapid screening, identification, and purification of neuraminidase inhibitors from Lithospermum erythrorhizon Sieb.et Zucc. by ultrafiltration with HPLC-ESI-TOF-MS combined with semipreparative HPLC","volume":"39","author":"Zhang M","year":"2016","journal-title":"J Sep Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/chir.22425","article-title":"A potent anticancer agent of shikonin derivative targeting tubulin","volume":"27","author":"Baloch SK","year":"2015","journal-title":"Chirality"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1055\/s-0033-1350934","article-title":"Pharmacological properties of shikonin - a review of literature since 2002","volume":"79","author":"Andujar I","year":"2013","journal-title":"Planta Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/1521-4184(200208)335:6<262::AID-ARDP262>3.0.CO;2-Y","article-title":"Alkannin and shikonin: effect on free radical processes and on inflammation - a preliminary pharmacochemical investigation","volume":"335","author":"Kourounakis AP","year":"2002","journal-title":"Arch Pharm"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1128\/AAC.47.9.2810-2816.2003","article-title":"Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1","volume":"47","author":"Chen X","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1517\/13543776.2012.709237","article-title":"Shikonin and its derivatives: a patent review","volume":"22","author":"Wang R","year":"2012","journal-title":"Expert Opin Ther Pat"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bcp.2015.04.021","article-title":"Synthesis of aryl dihydrothiazol acyl shikonin ester derivatives as anticancer agents through microtubule stabilization","volume":"96","author":"Lin HY","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"49796","DOI":"10.1039\/C4RA08810G","article-title":"Design, synthesis and biological evaluation of shikonin thio-glycoside derivatives: new anti-tubulin agents","volume":"4","author":"Lin H-Y","year":"2014","journal-title":"RSC Adv"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ejphar.2011.02.043","article-title":"Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition","volume":"658","author":"Lu L","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ijantimicag.2008.04.018","article-title":"Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71","volume":"32","author":"Lin CW","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijantimicag.2004.02.022","article-title":"Antiviral property and mode of action of a sulphated polysaccharide from Sargassum patens against herpes simplex virus type 2","volume":"24","author":"Zhu W","year":"2004","journal-title":"Int J Antimicrob Agents"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/ptr.1518","article-title":"Antiviral activities of medicinal herbs traditionally used in southern mainland China","volume":"18","author":"Li Y","year":"2004","journal-title":"Phytother Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2012.10.006","article-title":"Traditional Chinese herbal medicine as a source of molecules with antiviral activity","volume":"97","author":"Li T","year":"2013","journal-title":"Antiviral Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jep.2015.08.037","article-title":"Lariciresinol-4-O-beta-D-glucopyranoside from the root of Isatis indigotica inhibits influenza A virus-induced pro-inflammatory response","volume":"174","author":"Li J","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.3390\/v7082841","article-title":"The antiviral effect of baicalin on enterovirus 71 in vitro","volume":"7","author":"Li X","year":"2015","journal-title":"Viruses"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1743-422X-7-116","article-title":"Producing infectious enterovirus type 71 in a rapid strategy","volume":"7","author":"Han JF","year":"2010","journal-title":"Virol J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e76007","DOI":"10.1371\/journal.pone.0076007","article-title":"Chlorogenic acid inhibits the replication and viability of enterovirus 71 in vitro","volume":"8","author":"Li X","year":"2013","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/jac\/dkp502","article-title":"Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid","volume":"65","author":"Hung HC","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1423-0127-16-103","article-title":"Viral and host proteins involved in picornavirus life cycle","volume":"16","author":"Lin JY","year":"2009","journal-title":"J Biomed Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1128\/JVI.73.3.1941-1948.1999","article-title":"Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification","volume":"73","author":"Oberste MS","year":"1999","journal-title":"J Virol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.4161\/hv.21739","article-title":"Production of EV71 vaccine candidates","volume":"8","author":"Chong P","year":"2012","journal-title":"Hum Vaccin Immunother"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2217\/fmb.12.22","article-title":"Viral and host factors that contribute to pathogenicity of enterovirus 71","volume":"7","author":"Huang HI","year":"2012","journal-title":"Future Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12879-015-0965-1","article-title":"Cytokine responses and correlations thereof with clinical profiles in children with enterovirus 71 infections","volume":"15","author":"Ye N","year":"2015","journal-title":"BMC Infect Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"H1438","DOI":"10.1152\/ajpheart.00441.2014","article-title":"Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis","volume":"307","author":"Wang Y","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0008-6363(03)00437-1","article-title":"Myocarditis and dilated cardiomyopathy: an inflammatory link","volume":"60","author":"Mason JW","year":"2003","journal-title":"Cardiovasc Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1016\/j.bbamcr.2014.08.004","article-title":"The intricate interplay between RNA viruses and NF-kappaB","volume":"1843","author":"Schmitz ML","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1128\/JVI.01798-07","article-title":"Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD\/SCID mouse infection model","volume":"82","author":"Arita M","year":"2008","journal-title":"J Virol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF02253368","article-title":"Neutralizing antibody provided protection against enterovirus type 71 lethal challenge in neonatal mice","volume":"7","author":"Yu CK","year":"2000","journal-title":"J Biomed Sci"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v50n10\/1414-431X-bjmbr-1414-431X20176586.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T10:49:29Z","timestamp":1581072569000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2017001000602&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017]]}},"alternative-id":["S0100-879X2017001000602"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20176586","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]},"article-number":"e6586"}}