{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:02:24Z","timestamp":1753887744781,"version":"3.41.2"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","issue":"11","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20176665","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T19:40:09Z","timestamp":1505936409000},"source":"Crossref","is-referenced-by-count":12,"title":["Candesartan, rather than losartan, improves motor dysfunction in thioacetamide-induced chronic liver failure in rats"],"prefix":"10.1590","volume":"50","author":[{"given":"H.A.","family":"Murad","sequence":"first","affiliation":[{"name":"King Abdulaziz University,  Saudi Arabia; Ain Shams University,  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.J.","family":"Gazzaz","sequence":"additional","affiliation":[{"name":"King Abdulaziz University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Ali","sequence":"additional","affiliation":[{"name":"King Abdulaziz University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Ibraheem","sequence":"additional","affiliation":[{"name":"King Abdulaziz University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017]]},"reference":[{"issue":"(Suppl 1)","key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1746-6342.2006.03215.x","article-title":"Review article: the burden of hepatic encephalopathy","volume":"25","author":"Poordad FF","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00109-007-0160-y","article-title":"Cyclic GMP in blood and minimal hepatic encephalopathy: fine-tuning of the diagnosis","volume":"85","author":"Albrecht J","year":"2007","journal-title":"J Mol Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11011-010-9184-z","article-title":"Cyclic GMP pathways in hepatic encephalopathy: neurological and therapeutic implications","volume":"25","author":"Montoliu C","year":"2010","journal-title":"Metab Brain Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.3748\/wjg.15.2579","article-title":"Renin-angiotensin system in the pathogenesis of liver fibrosis","volume":"15","author":"Pereira RM","year":"2009","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1258\/ebm.2011.010375","article-title":"The role of the renin-angiotensin system in liver fibrosis","volume":"236","author":"Munshi MK","year":"2011","journal-title":"Exp Biol Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1097\/MJT.0b013e3181df8df5","article-title":"Hepatic fibrosis and the renin-angiotensin system","volume":"18","author":"Abbas G","year":"2011","journal-title":"Am J Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1023\/B:DDAS.0000043369.88701.5b","article-title":"Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats","volume":"49","author":"Wei YH","year":"2004","journal-title":"Dig Dis Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"G726","DOI":"10.1152\/ajpgi.00162.2009","article-title":"Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C","volume":"297","author":"Colmenero J","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/jhep.2001.28231","article-title":"Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats","volume":"34","author":"Yoshiji H","year":"2001","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1124\/pr.112.007278","article-title":"A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists","volume":"65","author":"Michel MC","year":"2013","journal-title":"Pharmacol Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3389\/fphar.2015.00303","article-title":"Hepatoprotective and Anti-fibrotic agents: it is time to take the next step","volume":"6","author":"Weiskirchen R","year":"2016","journal-title":"Front Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neulet.2013.11.058","article-title":"Low grade cirrhosis induces cognitive impairment and motor dysfunction in rats: Could be a model for minimal hepatic encephalopathy","volume":"559","author":"Singh S","year":"2014","journal-title":"Neurosci Lett"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jns.2006.10.014","article-title":"Co-administration of C-Phycocyanin ameliorates thioacetamide-induced hepatic encephalopathy in Wistar rats","volume":"252","author":"Sathyasaikumar KV","year":"2007","journal-title":"J Neurol Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0168-8278(02)00307-0","article-title":"Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and\/or portal hypertension","volume":"37","author":"Croquet V","year":"2002","journal-title":"J Hepatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10787-010-0068-y","article-title":"Neuroprotective potentials of candesartan, atorvastatin and their combination against stroke induced motor dysfunction","volume":"19","author":"Gaur V","year":"2011","journal-title":"Inflammopharmacology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.jpain.2013.05.012","article-title":"Activation of the AMP-activated protein kinase reduces inflammatory nociception","volume":"14","author":"Russe OQ","year":"2013","journal-title":"J Pain"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0893-133X(00)00150-0","article-title":"WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801","volume":"23","author":"Wedzony K","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa H","year":"1979","journal-title":"Anal Biochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/hep.23180","article-title":"Farnesyltransferase Inhibitors reduce ras activation and ameliorate acetaminophen-induced liver injury in mice","volume":"50","author":"Saha B","year":"2009","journal-title":"Hepatology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1478-3231.2005.01169.x","article-title":"Ginkgo biloba extract alleviates liver fibrosis induced by CCl in rats","volume":"25","author":"Ding J","year":"2005","journal-title":"Liver Int"},{"key":"ref21","first-page":"268","article-title":"Effect of tea polyphenol on cytokine gene expression in rats with alcoholic liver disease","volume":"5","author":"Zhang XG","year":"2006","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.4238\/2013.November.22.12","article-title":"Transient increase in IL-1\u03b2, IL-6 and TNF-\u03b1 gene expression in rat liver exposed to gold nanoparticles","volume":"12","author":"Khan HA","year":"2013","journal-title":"Genet Mol Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1745-7254.2006.00301.x","article-title":"Upregulation of TNF-alpha and IL-6 mRNA in mouse liver induced by bacille Calmette-Guerin plus lipopolysaccharide","volume":"27","author":"Liu DF","year":"2006","journal-title":"Acta Pharmacol Sin"},{"key":"ref24","first-page":"159","article-title":"Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat. The effect of AT1-R blocker on the hepatic fibrosis","volume":"55","author":"Tuncer I","year":"2003","journal-title":"Exp Toxicol Pathol"},{"key":"ref25","first-page":"1100","article-title":"Effect of an angiotensin-II type-1 receptor blocker, candesartan on hepatic fibrosis in chronic hepatitis C: a prospective study","volume":"56","author":"Ueki M","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"ref26","first-page":"1499","article-title":"Effect of losartan, an angiotensin II antagonist, on sondary biliary cirrhosis","volume":"49","author":"Ramalho LN","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/14756360500480673","article-title":"Tamarix gallica ameliorates thioacetamide-induced hepatic oxidative stress and hyperproliferative response in Wistar rats","volume":"21","author":"Sehrawat A","year":"2006","journal-title":"J Enzyme Inhib Med Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1161\/01.ATV.0000258415.32883.bf","article-title":"Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease","volume":"27","author":"Landmesser U","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1124\/jpet.114.218370","article-title":"Functions of galectin-3 and its role in fibrotic diseases","volume":"351","author":"Li LC","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e75361","DOI":"10.1371\/journal.pone.0075361","article-title":"Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liverdisease","volume":"8","author":"Traber PG","year":"2013","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.15252\/emmm.201505061","article-title":"Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms","volume":"7","author":"Nystr\u00f6m A","year":"2015","journal-title":"EMBO Mol Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1002\/art.23645","article-title":"The controversial role of tumor necrosis factor alpha in fibrotic diseases","volume":"58","author":"Distler JH","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.drudis.2015.10.015","article-title":"Emerging therapeutic targets for the treatment of hepatic fibrosis","volume":"21","author":"Fagone P","year":"2016","journal-title":"Drug Discov Today"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12974-016-0549-z","article-title":"Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia","volume":"13","author":"Hernandez-Rabaza V","year":"2016","journal-title":"J Neuroinflammation"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1038\/npp.2012.152","article-title":"Candesartan, an angiotensin II AT1-receptor blocker and PPAR-\u03b3 agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice","volume":"37","author":"Villapol S","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1177\/1470320313515038","article-title":"Beneficial effect of candesartan and lisinopril against haloperidol-induced tardive dyskinesia in rat","volume":"16","author":"Thakur KS","year":"2015","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1358\/mf.2010.32.9.1529826","article-title":"Effect of the AT1 receptor antagonist losartan on diurnal variation in pain threshold in spontaneously hypertensive rats","volume":"32","author":"Pechlivanova DM","year":"2010","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1211\/0022357001774994","article-title":"Comparative pharmacodynamics and pharmacokinetics of candesartan and losartan in man","volume":"52","author":"Fuchs B","year":"2000","journal-title":"J Pharm Pharmacol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3329\/bpj.v16i1.14484","article-title":"Binding affinity of candesartan, losartan, telmisartan and valsartan with angiotensin II receptor 1 subtype","volume":"16","author":"Bhuiyan MA","year":"2013","journal-title":"Bangladesh Pharm J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1440-1681.1994.tb02555.x","article-title":"Blockade by intravenous losartan of AT1 angiotensin II receptors in rat brain, kidney and adrenals demonstrated by in vitro autoradiography","volume":"21","author":"Zhuo J","year":"1994","journal-title":"Clin Exp Pharmacol Physiol"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v50n11\/1414-431X-bjmbr-1414-431X20176665.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T10:50:06Z","timestamp":1581072606000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2017001100611&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017]]}},"alternative-id":["S0100-879X2017001100611"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20176665","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"type":"electronic","value":"1414-431X"},{"type":"print","value":"0100-879X"}],"subject":[],"published":{"date-parts":[[2017]]},"article-number":"e6665"}}