{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:34:00Z","timestamp":1760646840445,"version":"3.41.2"},"reference-count":39,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20186602","type":"journal-article","created":{"date-parts":[[2018,5,19]],"date-time":"2018-05-19T20:44:11Z","timestamp":1526762651000},"source":"Crossref","is-referenced-by-count":8,"title":["Low-protein diet does not alter reproductive, biochemical, and hematological parameters in pregnant Wistar rats"],"prefix":"10.1590","volume":"51","author":[{"given":"M.A.V.","family":"Barros","sequence":"first","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.B.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.G.N.","family":"Barros","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.K.M.","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.C.L.","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.F.A.","family":"Vitorino","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.C.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Paulino-Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.O.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"de Brito Alves","sequence":"additional","affiliation":[{"name":"Universidade Federal de Para\u00edba,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Costa-Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/14647270500320121","article-title":"Nutritional paradigms of ovine fetal growth restriction: implications for human pregnancy","volume":"8","author":"Luther JS","year":"2005","journal-title":"Hum Fertil"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/03014460902980295","article-title":"Growth and chronic disease: findings in the Helsinki Birth Cohort","volume":"36","author":"Barker DJP","year":"2009","journal-title":"Ann Hum Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/427411b","article-title":"Lifespan: catch-up growth and obesity in male mice","volume":"427","author":"Ozanne SE","year":"2004","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1071\/RD14455","article-title":"Do little embryos make big decisions? How maternal dietary protein restriction can permanently change an embryo","volume":"27","author":"Fleming TP","year":"2015","journal-title":"Reprod Fertil Dev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.numecd.2014.07.011","article-title":"Maternal low-protein diet induces changes in the cardiovascular autonomic modulation in male rat offspring","volume":"25","author":"Barros MA","year":"2015","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1017\/S0007114513002833","article-title":"Short- and long-term effects of a maternal low-protein diet on ventilation, O(2)\/CO(2) chemoreception and arterial blood pressure in male rat offspring","volume":"111","author":"de Brito Alves JL","year":"2014","journal-title":"Br J Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.3390\/nu7021202","article-title":"Altered fetal skeletal muscle nutrient metabolism following an adverse in utero environment and the modulation of later life insulin sensitivity","volume":"7","author":"Dunlop K","year":"2015","journal-title":"Nutrients"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e13582","DOI":"10.1371\/journal.pone.0013582","article-title":"Hypertension, diabetes and overweight: looming legacies of the Biafran famine","volume":"5","author":"Hult M","year":"2010","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20070113","article-title":"Mechanisms underlying developmental programming of elevated blood pressure and vascular dysfunction: evidence from human studies and experimental animal models","volume":"114","author":"Nuyt AM","year":"2008","journal-title":"Clin Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3945\/jn.114.202804","article-title":"Maternal protein restriction increases respiratory and sympathetic activities and sensitizes peripheral chemoreflex in male rat offspring","volume":"145","author":"de Brito Alves JL","year":"2015","journal-title":"J Nutr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"R368","DOI":"10.1152\/ajpregu.00206.2004","article-title":"Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring","volume":"288","author":"Fernandez-Twinn DS","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref12","first-page":"70","article-title":"Differential developmental programming by early protein restriction of rat skeletal muscle according to its fibre-type composition","volume":"210","author":"da Silva Aragao R","year":"2014","journal-title":"Acta"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJMoa044160","article-title":"Trajectories of growth among children who have coronary events as adults","volume":"353","author":"Barker DJP","year":"2005","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1073\/pnas.83.5.1388","article-title":"Alternative adaptations, speciation, and phylogeny (A Review)","volume":"83","author":"West-Eberhard MJ","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.placenta.2014.01.012","article-title":"The human placenta expresses multiple glucocorticoid receptor isoforms that are altered by fetal sex, growth restriction and maternal asthma","volume":"35","author":"Saif Z","year":"2014","journal-title":"Placenta"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1017\/S1751731115001147","article-title":"Effect of protein or energy restriction during late gestation on hormonal and metabolic status in pregnant goats and postnatal male offspring","volume":"9","author":"He ZX","year":"2015","journal-title":"Animal"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"805418","DOI":"10.1155\/2012\/805418","article-title":"Maternal moderate physical training during pregnancy attenuates the effects of a low-protein diet on the impaired secretion of insulin in rats: potential role for compensation of insulin resistance and preventing gestational diabetes mellitus","volume":"2012","author":"Leandro CG","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"ref18","series-title":"Guidelines for developmental toxicity risk assessment","first-page":"63798","volume":"56","year":"1991"},{"key":"ref19","series-title":"Handbook of in vivo toxicity testing","first-page":"271","volume-title":"Developmental toxicity studies","author":"Kimmel CA","year":"1990"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"S838","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A diet","volume":"127","author":"Reeves PG","year":"1997","journal-title":"J Nutrition"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jep.2007.02.004","article-title":"A toxicological evaluation of the effect of Carapa guianensis Aublet on pregnancy in Wistar rats","volume":"112","author":"Costa-Silva JH","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/(SICI)1099-1573(200003)14:2<99::AID-PTR600>3.0.CO;2-4","article-title":"Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats","volume":"14","author":"de Almeida ER","year":"2000","journal-title":"Phytother Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jep.2007.12.016","article-title":"Acute and subacute toxicity of the Carapa guianensis Aublet (Meliaceae) seed oil","volume":"116","author":"Costa-Silva JH","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0378-8741(00)00275-0","article-title":"The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats","volume":"73","author":"Almeida FCG","year":"2000","journal-title":"J Ethnopharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1590\/S0100-879X1997000800012","article-title":"Food intake and weight of lactating rats maintained on different protein-calorie diets, and pup growth","volume":"30","author":"Cambraia RP","year":"1997","journal-title":"Braz J Med Biol Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1271\/bbb.68.488","article-title":"The effects of maternal mild protein restriction on stroke incidence and blood pressure in stroke-prone spontaneously hypertensive rats (SHRSP)","volume":"68","author":"Otani L","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.ajog.2004.09.008","article-title":"Antihypertensive effects of flutamide in rats that are exposed to a low-protein diet in utero","volume":"192","author":"Gangula PR","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1440-1681.2009.05212.x","article-title":"Placental oxidative stress in malnourished rats and changes in kidney proximal tubule sodium ATPases in offspring","volume":"36","author":"Vieira-Filho LD","year":"2009","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"(Part 1)","key":"ref29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1113\/jphysiol.2005.103903","article-title":"Protein restriction during fetal and neonatal development in the rat alters reproductive function and accelerates reproductive ageing in female progeny","volume":"572","author":"Guzman C","year":"2006","journal-title":"J Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/1440-1681.12092","article-title":"Developmental programming: variations in early growth and adult disease","volume":"40","author":"Gallo LA","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"iii","DOI":"10.1071\/RDv27n5_IN","article-title":"Epigenetics and periconception environment: an introduction","volume":"27","author":"Van Soom A","year":"2015","journal-title":"Reprod Fertil Dev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1113\/JP271543","article-title":"Resveratrol partially prevents oxidative stress and metabolic dysfunction in pregnant rats fed a low protein diet and their offspring","volume":"594","author":"Vega CC","year":"2016","journal-title":"J Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10735-013-9522-7","article-title":"Gestational protein restriction induces alterations in placental morphology and mitochondrial function in rats during late pregnancy","volume":"44","author":"Rebelato HJ","year":"2013","journal-title":"J Mol Histol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1271\/bbb.68.488","article-title":"The effects of maternal mild protein restriction on stroke incidence and blood pressure in stroke-prone spontaneously hypertensive rats (SHRSP)","volume":"68","author":"Otani L","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3177\/jnsv.52.414","article-title":"Long-term effect of early protein malnutrition on growth curve, hematological parameters and macrophage function of rats","volume":"52","author":"Prestes-Carneiro LE","year":"2006","journal-title":"J Nutr Sci Vitaminol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0378-8741(02)00092-2","article-title":"Fetal toxicity of Solanum lycocarpum (Solanaceae) in rats","volume":"81","author":"Chang CV","year":"2002","journal-title":"J Ethnopharmacol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/jn\/135.8.1873","article-title":"Low-protein diets reduce PKAalpha expression in islets from pregnant rats","volume":"135","author":"Milanski M","year":"2005","journal-title":"J Nutr"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/cbf.1824","article-title":"A low-protein diet during pregnancy alters glucose metabolism and insulin secretion","volume":"30","author":"Souza Dde F","year":"2012","journal-title":"Cell Biochem Funct"},{"key":"ref39","first-page":"1","article-title":"miR-124a expression contributes to the monophasic pattern of insulin secretion in islets from pregnant rats submitted to a low-protein diet","author":"de Siqueira KC","year":"2017","journal-title":"Eur J Nutr"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v51n6\/1414-431X-bjmbr-51-6-e6602.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T13:06:17Z","timestamp":1581426377000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2018000600613&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018]]}},"alternative-id":["S0100-879X2018000600613"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20186602","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"type":"electronic","value":"1414-431X"},{"type":"print","value":"0100-879X"}],"subject":[],"published":{"date-parts":[[2018]]},"article-number":"e6602"}}