{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:32:27Z","timestamp":1792701147454,"version":"4.5.0"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"9","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20187602","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T22:35:10Z","timestamp":1532730910000},"source":"Crossref","is-referenced-by-count":32,"title":["NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice"],"prefix":"10.1590","volume":"51","author":[{"given":"Ming-lei","family":"Chen","sequence":"first","affiliation":[{"name":"Third People's Hospital of Hainan Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Lin","sequence":"additional","affiliation":[{"name":"Third People's Hospital of Hainan Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-kai","family":"Lin","sequence":"additional","affiliation":[{"name":"Third People's Hospital of Hainan Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1172\/JCI81950","article-title":"CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5","volume":"126","author":"Jiang BC","year":"2016","journal-title":"J Clin Invest"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e0133707","DOI":"10.1371\/journal.pone.0133707","article-title":"Neuropathic pain phenotype does not involve the NLRP3 inflammasome and its end product interleukin-1beta in the mice spared nerve injury model","volume":"10","author":"Curto-Reyes V","year":"2015","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12974-016-0540-8","article-title":"Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection","volume":"13","author":"Martini AC","year":"2016","journal-title":"J Neuroinflammation"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.jpain.2013.08.010","article-title":"TGF-beta1 attenuates spinal neuroinflammation and the excitatory amino acid system in rats with neuropathic pain","volume":"14","author":"Chen NF","year":"2013","journal-title":"J Pain"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"E3441","DOI":"10.1073\/pnas.1602070113","article-title":"Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation","volume":"113","author":"Grace PM","year":"2016","journal-title":"Proc Natl Acad Sci U A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s12264-013-1328-9","article-title":"Research progress on the NLRP3 inflammasome and its role in the central nervous system","volume":"29","author":"Liu SB","year":"2013","journal-title":"Neurosci Bull"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"9238290","DOI":"10.1155\/2016\/9238290","article-title":"Recent advances of the NLRP3 inflammasome in central nervous system disorders","volume":"2016","author":"Zhou K","year":"2016","journal-title":"J Immunol Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e0130624","DOI":"10.1371\/journal.pone.0130624","article-title":"NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes","volume":"10","author":"Gustin A","year":"2015","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbi.2017.08.004","article-title":"Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain","volume":"67","author":"Gao F","year":"2018","journal-title":"Brain Behav Immun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel DP","year":"2009","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.expneurol.2016.06.025","article-title":"Increased miR-132-3p expression is associated with chronic neuropathic pain","volume":"283","author":"Leinders M","year":"2016","journal-title":"Exp Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1523\/JNEUROSCI.0646-16.2016","article-title":"mir-500-Mediated GAD67 downregulation contributes to neuropathic pain","volume":"36","author":"Huang ZZ","year":"2016","journal-title":"J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1093\/brain\/awt191","article-title":"miR-7a alleviates the maintenance of neuropathic pain through regulation of neuronal excitability","volume":"136","author":"Sakai A","year":"2013","journal-title":"Brain"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s11064-014-1500-2","article-title":"Suppression of microRNA-155 attenuates neuropathic pain by regulating SOCS1 signalling pathway","volume":"40","author":"Tan Y","year":"2015","journal-title":"Neurochem Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e111594","DOI":"10.1371\/journal.pone.0111594","article-title":"Decreased microRNA-125a-3p contributes to upregulation of p38 MAPK in rat trigeminal ganglions with orofacial inflammatory pain","volume":"9","author":"Dong Y","year":"2014","journal-title":"PLoS One"},{"key":"ref16","first-page":"15","article-title":"Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain","volume":"3","author":"Bai G","year":"2007","journal-title":"Mol Pain"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1526-4610.2012.02226.x","article-title":"Spontaneous behavioral responses in the orofacial region: a model of trigeminal pain in mouse","volume":"53","author":"Romero-Reyes M","year":"2013","journal-title":"Headache"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1744-8069-6-89","article-title":"Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus","volume":"6","author":"Villa G","year":"2010","journal-title":"Mol Pain"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak KJ","year":"2001","journal-title":"Methods"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/glia.22451","article-title":"Increased miR-195 aggravates neuropathic pain by inhibiting autophagy following peripheral nerve injury","volume":"61","author":"Shi G","year":"2013","journal-title":"Glia"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11064-013-1192-z","article-title":"Intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following chronic construction injury","volume":"39","author":"Chen HP","year":"2014","journal-title":"Neurochem Res"},{"key":"ref22","first-page":"801.e1","article-title":"MicroRNA changes in the mouse prefrontal cortex after inflammatory pain","volume":"15","author":"Poh KW","year":"2011","journal-title":"Eur J Pain"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.3892\/ijo.2016.3637","article-title":"MicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer","volume":"49","author":"Huang T","year":"2016","journal-title":"Int J Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1007\/s13277-015-4117-4","article-title":"miR-186 downregulates protein phosphatase PPM1B in bladder cancer and mediates G1-S phase transition","volume":"37","author":"Yang J","year":"2016","journal-title":"Tumour Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbrc.2015.11.136","article-title":"miR-186 inhibits cell proliferation in multiple myeloma by repressing Jagged1","volume":"469","author":"Liu Z","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fnmol.2014.00009","article-title":"Predicted overlapping microRNA regulators of acetylcholine packaging and degradation in neuroinflammation-related disorders","volume":"7","author":"Nadorp B","year":"2014","journal-title":"Front Mol Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbi.2016.08.004","article-title":"Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury","volume":"58","author":"Ellis A","year":"2016","journal-title":"Brain Behav Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neulet.2015.12.017","article-title":"Demyelination\/remyelination and expression of interleukin-1beta, substance P, nerve growth factor, and glial-derived neurotrophic factor during trigeminal neuropathic pain in rats","volume":"612","author":"Costa GM","year":"2016","journal-title":"Neurosci Lett"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neulet.2012.09.007","article-title":"Increased expression of interleukin-18 in the trigeminal spinal subnucleus caudalis after inferior alveolar nerve injury in the rat","volume":"529","author":"Daigo E","year":"2012","journal-title":"Neurosci Lett"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v51n9\/1414-431X-bjmbr-51-9-e7602.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T13:09:57Z","timestamp":1581426597000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2018000900607&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018]]}},"alternative-id":["S0100-879X2018000900607"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20187602","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]},"article-number":"e7602"}}