{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:15:45Z","timestamp":1772950545826,"version":"3.50.1"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20187879","type":"journal-article","created":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T15:32:09Z","timestamp":1550935929000},"source":"Crossref","is-referenced-by-count":1,"title":["Observation of the effect of bone marrow mesenchymal stem cell transplantation by different interventions on cirrhotic rats"],"prefix":"10.1590","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5517-808X","authenticated-orcid":false,"given":"Xiaoling","family":"Zhou","sequence":"first","affiliation":[{"name":"Graduate School of Hunan University of Traditional Chinese Medicine,  China; Liuzhou Traditional Chinese Medicine Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7867-7957","authenticated-orcid":false,"given":"Jianqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Liuzhou Traditional Chinese Medicine Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-742X","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Liuzhou Traditional Chinese Medicine Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4878-6458","authenticated-orcid":false,"given":"Zepeng","family":"Li","sequence":"additional","affiliation":[{"name":"Liuzhou Traditional Chinese Medicine Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1948-1150","authenticated-orcid":false,"given":"Jingfang","family":"Yu","sequence":"additional","affiliation":[{"name":"Liuzhou Traditional Chinese Medicine Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-0258","authenticated-orcid":false,"given":"Wanhua","family":"Wei","sequence":"additional","affiliation":[{"name":"Guangxi University of Traditional Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-3526","authenticated-orcid":false,"given":"Qiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Liuzhou Traditional Chinese Medicine Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2290-0769","authenticated-orcid":false,"given":"Can","family":"Li","sequence":"additional","affiliation":[{"name":"Liuzhou Traditional Chinese Medicine Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-2438","authenticated-orcid":false,"given":"Nong","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangxi University of Traditional Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3329\/bmj.v45i3.33137","article-title":"Hepatitis B virus remains the leading cause of cirrhosis of liver in Bangladesh","volume":"45","author":"Das DC","year":"2017","journal-title":"Bangladesh Med J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/CCM.0000000000002961","article-title":"Incidence and outcomes for patients with cirrhosis admitted to the United Kingdom critical care units","volume":"46","author":"McPhail MJW","year":"2018","journal-title":"Crit Care Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.11569\/wcjd.v24.i3.362","article-title":"Human umbilical cord mesenchymal stem cells for treatment of cirrhosis [in chinese]","volume":"24","author":"Duan D","year":"2016","journal-title":"World Chinese Journal of Digestology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fimmu.2014.00148","article-title":"The life and fate of mesenchymal stem cells","volume":"5","author":"Eggenhofer E","year":"2014","journal-title":"Front Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbrc.2007.05.150","article-title":"Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells","volume":"363","author":"Parekkadan B","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.3748\/wjg.v11.i22.3431","article-title":"Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats","volume":"11","author":"Zhao DC","year":"2005","journal-title":"World J Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3748\/wjg.v18.i10.1048","article-title":"Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis","volume":"18","author":"Zhao W","year":"2012","journal-title":"World J Gastroenterol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exphem.2017.09.009","article-title":"Human bone marrow mesenchymal stem cells secrete endocannabinoids that stimulate in vitro hematopoietic stem cell migration effectively comparable to beta adrenergic stimulation","volume":"57","author":"K\u00f6se S","year":"2018","journal-title":"Exp Hematol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S2468-1253(17)30326-6","article-title":"Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial","volume":"3","author":"Newsome PN","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/1673-5374.150717","article-title":"Dorsal root ganglion neurons promote proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"10","author":"Zhang PX","year":"2015","journal-title":"Neural Regen Res"},{"key":"ref11","first-page":"792161","article-title":"Promoting effects on proliferation and chondrogenic differentiation of bone marrow-derived mesenchymal stem cells by four \u201ckidney-tonifying\u201d traditional chinese herbs","volume":"2015","author":"Cai B","year":"2015","journal-title":"Biomed Res Int"},{"key":"ref12","first-page":"273","article-title":"Regulatory effect of bone marrow mesenchymal stem cells on polarization of macrophages","volume":"25","author":"Hou Y","year":"2017","journal-title":"Chinese J Hepatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jhep.2011.09.021","article-title":"The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis","volume":"56","author":"Kisseleva T","year":"2012","journal-title":"J Hepatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/jocd.12512","article-title":"The effect of mesenchymal stem cells combined with platelet-rich plasma on skin wound healing","volume":"17","author":"Mahmoudiansani-Sani MR","year":"2018","journal-title":"J Cosmet Dermatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.clinbiochem.2007.04.017","article-title":"Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis","volume":"40","author":"Abdel Aziz MT","year":"2007","journal-title":"Clin Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3892\/mmr.2015.4673","article-title":"Role of autophagy on bone marrow mesenchymal stem-cell proliferation and differentiation into neurons","volume":"13","author":"Li B","year":"2016","journal-title":"Mol Med Rep"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1089\/scd.2016.0308","article-title":"Dynamic regulation of TWIST1 expression during chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells","volume":"26","author":"Cleary MA","year":"2017","journal-title":"Stem Cells Dev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.3748\/wjg.v10.i19.2818","article-title":"Hepatic differentiation capability of rat bone marrow-derived mesenchymal stem cells and hematopoietic stem cells","volume":"10","author":"Shu SN","year":"2004","journal-title":"World J Gastroenterol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.3748\/wjg.v11.i22.3431","article-title":"Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats","volume":"11","author":"Zhao DC","year":"2005","journal-title":"World J Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4103\/0974-8490.91040","article-title":"Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats","volume":"4","author":"Tatiya AU","year":"2011","journal-title":"Pharmacognosy Research"},{"key":"ref21","series-title":"Dietary exposure effect of sublethal doses of methomyl on growth performance and biochemical changes in rabbits and the protective role of vitamin e plus selenium","first-page":"59","volume":"25","author":"El-Sheikh ESA","year":"2015"},{"key":"ref22","first-page":"459","article-title":"Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis","volume":"10","author":"Mohamadnejad M","year":"2007","journal-title":"Arch Iran Med"},{"key":"ref23","first-page":"71","article-title":"Evaluation of the ELISA and the enhanced chemiluminescence immunoassay in use to determine the serum markers for liver fibrosis","volume":"23","author":"Guo JX","year":"2009","journal-title":"Chin J Exp Clin Virol"},{"key":"ref24","first-page":"1","article-title":"Hepatoprotective effects of loach (Misgurnus anguillicaudatus) lyophilized powder on dimethylnitrosamine-induced liver fibrosis in rats","author":"Qian Z","year":"2014","journal-title":"Arch Pharm Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/1751-2980.12584","article-title":"Are we any closer to treating liver fibrosis (and if no, why not)?","volume":"19","author":"Feng R","year":"2018","journal-title":"J Dig Dis"},{"key":"ref26","first-page":"203","article-title":"High serum N-terminal propeptide of procollagen type III concentration is associated with liver diseases","volume":"12","author":"Gudowska M","year":"2017","journal-title":"Prz Gastroenterol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.jtcvs.2016.01.020","article-title":"Ventricular fibrogenesis activity assessed by serum levels of procollagen type III N-terminal amino peptide during the staged Fontan procedure","volume":"151","author":"Sugimoto M","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0022-3468(05)80094-6","article-title":"Laminin and procollagen-III-peptide as a serum marker for hepatic fibrosis in congenital biliary atresia","volume":"27","author":"Sasaki F","year":"1992","journal-title":"J Pediatr Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1089\/scd.2012.0438","article-title":"A soluble granulocyte colony stimulating factor decoy receptor as a novel tool to increase hematopoietic cell homing and reconstitution in mice","volume":"22","author":"Fortin A","year":"2013","journal-title":"Stem Cells Dev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"H1466","DOI":"10.1152\/ajpheart.00033.2010","article-title":"Comparison of parathyroid hormone and G-CSF treatment after myocardial infarction on perfusion and stem cell homing","volume":"298","author":"Huber BC","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/ni813","article-title":"G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4","volume":"3","author":"Petit I","year":"2002","journal-title":"Nat Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.exphem.2004.09.005","article-title":"G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs","volume":"33","author":"Yannaki E","year":"2005","journal-title":"Exp Hematol"},{"key":"ref33","article-title":"Clinical efficacy of Jisheng Shenqi decoction combined with interferon in HBeAg-positive chronic hepatitis B of Spleen-kidney Yang deficiency","volume":"34","author":"Zhou X","year":"2013","journal-title":"Modern Journal of Integrated Traditional Chinese & Western Medicine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.11569\/wcjd.v23.i7.1104","article-title":"Effect of Jisheng Shenqi decoction on homing of stem cells to the liver after bone marrow mesenchymal stem cell transplantation in cirrhotic rats. [in Chinese]","volume":"23","author":"Liu Y","year":"2015","journal-title":"World Chinese Journal of Digestology"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v52n3\/1414-431X-bjmbr-52-3-e7879.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T07:56:19Z","timestamp":1581407779000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2019000300606&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019]]}},"alternative-id":["S0100-879X2019000300606"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20187879","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"article-number":"e7879"}}