{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:07:33Z","timestamp":1788887253256,"version":"build-2803163510"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20198434","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T19:22:32Z","timestamp":1560972152000},"source":"Crossref","is-referenced-by-count":43,"title":["Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress"],"prefix":"10.1590","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-3387","authenticated-orcid":false,"given":"Juying","family":"Zhong","sequence":"first","affiliation":[{"name":"Tongde Hospital of Zhejiang Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6562-8347","authenticated-orcid":false,"given":"Gonghua","family":"Li","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8235-6198","authenticated-orcid":false,"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-104X","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-5506","authenticated-orcid":false,"given":"Mingming","family":"Shi","sequence":"additional","affiliation":[{"name":"Elderly Care Hospital of Zhejiang Province,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/WNR.0000000000000747","article-title":"Cucurbitacin IIa exerts antidepressant-like effects on mice exposed to chronic unpredictable mild stress","volume":"28","author":"Zhou SM","year":"2017","journal-title":"Neuroreport"},{"key":"ref2","first-page":"1","article-title":"Depression: out-of-tune embodiment, loss of bodily resonance, and body work","author":"Ronberg MT","year":"2018","journal-title":"Med Anthropol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1038\/s41598-017-07407-1","article-title":"Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism","volume":"7","author":"Yan T","year":"2017","journal-title":"Sci Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.intimp.2017.10.001","article-title":"Senegenin exerts anti-depression effect in mice induced by chronic un-predictable mild stress via inhibition of NF-\u03baB regulating NLRP3 signal pathway","volume":"53","author":"Li H","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jphs.2017.03.007","article-title":"Ginsenoside Rg3 exerts anti-depressive effect on an NMDA-treated cell model and a chronic mild stress animal model","volume":"134","author":"Zhang H","year":"2017","journal-title":"J Pharmacol Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"E1386","DOI":"10.3390\/molecules22081386","article-title":"Effects of refined xiaoyaosan on depressive-like behaviors in rats with chronic unpredictable mild stress through neurosteroids, their synthesis and metabolic enzymes","volume":"22","author":"Guo X","year":"2017","journal-title":"Molecules"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7254016","DOI":"10.1155\/2018\/7254016","article-title":"TLR4-NF-kappaB signal involved in depressive-like behaviors and cytokine expression of frontal cortex and hippocampus in stressed C57BL\/6 and ob\/ob mice","volume":"2018","author":"Wang Y","year":"2018","journal-title":"Neural Plast"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.psychres.2017.07.081","article-title":"Schisandrin rescues depressive-like behaviors induced by chronic unpredictable mild stress via GDNF\/ERK1\/2\/ROS and PI3K\/AKT\/NOX signaling pathways in mice","volume":"257","author":"Wan S","year":"2017","journal-title":"Psychiatry Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/157339510791823835","article-title":"The concept of depression as a dysfunction of the immune system","volume":"6","author":"Leonard BE","year":"2010","journal-title":"Curr Immunol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller AH","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e0197267","DOI":"10.1371\/journal.pone.0197267","article-title":"Changes in the serum levels of inflammatory cytokines in antidepressant drug-naive patients with major depression","volume":"13","author":"Zou W","year":"2018","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/mp.2012.125","article-title":"Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder","volume":"18","author":"Rethorst CD","year":"2013","journal-title":"Mol Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1503\/jpn.130169","article-title":"BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice","volume":"39","author":"Yi LT","year":"2014","journal-title":"J Psychiatry Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.psychres.2016.07.020","article-title":"Dexmedetomidine protects against learning and memory impairments caused by electroconvulsive shock in depressed rats: Involvement of the NMDA receptor subunit 2B (NR2B)-ERK signaling pathway","volume":"243","author":"Gao X","year":"2016","journal-title":"Psychiatry Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e0183702","DOI":"10.1371\/journal.pone.0183702","article-title":"Longistyline C acts antidepressant in vivo and neuroprotection in vitro against glutamate-induced cytotoxicity by regulating NMDAR\/NR2B-ERK pathway in PC12 cells","volume":"12","author":"Liu Y","year":"2017","journal-title":"Plos One"},{"key":"ref16","first-page":"577","article-title":"Hippocampus quinolinic acid modulates glutamate and NMDAR\/mGluR1 in chronic unpredictable mild stress-induced depression","volume":"65","author":"Chen HB","year":"2013","journal-title":"Sheng Li Xue Bao"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0896-6273(03)00645-7","article-title":"The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1","volume":"40","author":"Krapivinsky G","year":"2003","journal-title":"Neuron"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"E2133","DOI":"10.3390\/ijms18102133","article-title":"3,5,6,7,8,3\u2032,4\u2032-heptamethoxyflavone ameliorates depressive-like behavior and hippocampal neurochemical changes in chronic unpredictable mild stressed mice by regulating the brain-derived neurotrophic factor: requirement for ERK activation","volume":"18","author":"Sawamoto A","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"28386","DOI":"10.3390\/ijms161226105","article-title":"Neuropeptide trefoil factor 3 reverses depressive-like behaviors by activation of BDNF-ERK-CREB signaling in olfactory bulbectomized rats","volume":"16","author":"Li J","year":"2015","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jep.2017.01.037","article-title":"Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signalling pathway and reversal of HPA axis hyperactivity","volume":"199","author":"Li Q","year":"2017","journal-title":"J Ethnopharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4306\/pi.2017.14.1.74","article-title":"Reversion of BDNF, Akt and CREB in hippocampus of chronic unpredictable stress induced rats: effects of phytochemical, Bacopa Monnieri","volume":"14","author":"Hazra S","year":"2017","journal-title":"Psychiatry Investig"},{"key":"ref22","first-page":"113","article-title":"Anti-cerebral ischemia\/reperfusion mechanism of baicalin in rats [in Chinese]","author":"Wang WJ","year":"2016","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2017.12.049","article-title":"MiR-1275 promotes cell migration, invasion and proliferation in squamous cell carcinoma of head and neck via up-regulating IGF-1R and CCR7","volume":"646","author":"Liu MD","year":"2018","journal-title":"Gene"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbrc.2014.07.041","article-title":"Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats","volume":"451","author":"Yu HY","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbr.2015.04.052","article-title":"Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice","volume":"291","author":"Deng XY","year":"2015","journal-title":"Behav Brain Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"pyw037","DOI":"10.1093\/ijnp\/pyw037","article-title":"Fluoxetine inhibits NLRP3 inflammasome activation: implication in depression","volume":"19","author":"Du RH","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref27","first-page":"178","article-title":"Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice","volume":"27","author":"Bourin M","year":"2002","journal-title":"J Psychiatry Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ecoenv.2017.08.028","article-title":"Cell metabolomics reveals the neurotoxicity mechanism of cadmium in PC12 cells","volume":"147","author":"Zong L","year":"2018","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2010.09.095","article-title":"Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat","volume":"1366","author":"Zhang Y","year":"2010","journal-title":"Brain Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fitote.2011.09.017","article-title":"Antidepressant-like effects of the saponins extracted from Chaihu-jia-longgu-muli-tang in a rat unpredictable chronic mild stress model","volume":"83","author":"Li LF","year":"2012","journal-title":"Fitoterapia"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11920-011-0232-0","article-title":"Is depression an inflammatory disorder?","volume":"13","author":"Raison CL","year":"2011","journal-title":"Curr Psychiatry Rep"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2014.03.012","article-title":"Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3-dioxygenase activation","volume":"41","author":"Andr\u00e9 C","year":"2014","journal-title":"Brain Behav Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ecoenv.2017.08.028","article-title":"Cell metabolomics reveals the neurotoxicity mechanism of cadmium in PC12 cells","volume":"147","author":"Zong L","year":"2017","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1523\/JNEUROSCI.0640-10.2010","article-title":"Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning","volume":"30","author":"Brigman JL","year":"2010","journal-title":"J Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0092-8674(02)00657-8","article-title":"Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture","volume":"108","author":"Barco A","year":"2002","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0959-4388(02)00327-6","article-title":"Molecular mechanisms of CaMKII activation in neuronal plasticity","volume":"12","author":"Fink CC","year":"2002","journal-title":"Curr Opin Neurobiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1523\/JNEUROSCI.22-09-03359.2002","article-title":"Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region","volume":"22","author":"Sanna PP","year":"2002","journal-title":"J Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnmol.2013.00027","article-title":"CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning","volume":"6","author":"Gillespie JM","year":"2013","journal-title":"Front Mol Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12640-016-9611-y","article-title":"Baicalin attenuates ketamine-induced neurotoxicity in the developing rats: involvement of PI3K\/Akt and CREB\/BDNF\/Bcl-2 pathways","volume":"30","author":"Zuo D","year":"2016","journal-title":"Neurotox Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"9334","DOI":"10.1007\/s12035-018-1042-8","article-title":"Baicalin modulates APPL2\/glucocorticoid receptor signaling cascade, promotes neurogenesis, and attenuates emotional and olfactory dysfunctions in chronic corticosterone-induced depression","volume":"55","author":"Gao C","year":"2018","journal-title":"Mol Neurobiol"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v52n7\/1414-431X-bjmbr-52-7-e8434.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T19:31:46Z","timestamp":1581103906000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2019000700602&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019]]}},"alternative-id":["S0100-879X2019000700602"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20198434","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"article-number":"e8434"}}