{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:03:06Z","timestamp":1790272986383,"version":"4.1.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x20199106","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T07:58:30Z","timestamp":1579852710000},"source":"Crossref","is-referenced-by-count":86,"title":["miR-26a-5p protects against myocardial ischemia\/reperfusion injury by regulating the PTEN\/PI3K\/AKT signaling pathway"],"prefix":"10.1590","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-2942","authenticated-orcid":false,"given":"Xiaowei","family":"Xing","sequence":"first","affiliation":[{"name":"Second Hospital of Shandong University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2705-057X","authenticated-orcid":false,"given":"Shuang","family":"Guo","sequence":"additional","affiliation":[{"name":"Second Hospital of Shandong University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-3211","authenticated-orcid":false,"given":"Guanghao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Second Hospital of Shandong University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2317-6546","authenticated-orcid":false,"given":"Yusheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Second Hospital of Shandong University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-9855","authenticated-orcid":false,"given":"Shaojie","family":"Bi","sequence":"additional","affiliation":[{"name":"Second Hospital of Shandong University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-5515","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Hospital of Shandong University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-3895","authenticated-orcid":false,"given":"Qinghua","family":"Lu","sequence":"additional","affiliation":[{"name":"Second Hospital of Shandong University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1606915","article-title":"Acute myocardial infarction","volume":"376","author":"Anderson JL","year":"2017","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1124\/pr.113.008300","article-title":"Interaction of risk factors, comorbidities, and comedications with ischemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning","volume":"66","author":"Ferdinandy P","year":"2014","journal-title":"Pharmacol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","article-title":"Evolving therapies for myocardial ischemia\/reperfusion injury","volume":"65","author":"Ibanez B","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy DJ","year":"2013","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1089253211436350","article-title":"Myocardial ischemia reperfusion injury: from basic science to clinical bedside","volume":"16","author":"Frank A","year":"2012","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1124\/pr.107.06002","article-title":"Interaction of cardiovascular risk factors with myocardial ischemia\/reperfusion injury, preconditioning, and postconditioning","volume":"59","author":"Ferdinandy P","year":"2007","journal-title":"Pharmacol Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","article-title":"Multitarget strategies to reduce myocardial ischemia\/reperfusion injury: JACC review topic of the week","volume":"73","author":"Davidson SM","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.eururo.2015.12.054","article-title":"The potential of MicroRNAs as prostate cancer biomarkers","volume":"70","author":"Fabris L","year":"2016","journal-title":"Eur Urol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.semcancer.2017.03.005","article-title":"microRNAs as players and signals in the metastatic cascade: Implications for the development of novel anti-metastatic therapies","volume":"44","author":"Gandellini P","year":"2017","journal-title":"Semin Cancer Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1476-4598-9-232","article-title":"Cooperative and individualistic functions of the microRNAs in the miR-23a\u223c27a\u223c24-2 cluster and its implication in human diseases","volume":"9","author":"Chhabra R","year":"2010","journal-title":"Mol Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nrrheum.2012.236","article-title":"MicroRNA in 2012: Biotherapeutic potential of microRNAs in rheumatic diseases","volume":"9","author":"Pers YM","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2014.06.005","article-title":"MicroRNAs in cancer: biomarkers, functions and therapy","volume":"20","author":"Hayes J","year":"2014","journal-title":"Trends Mol Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s40291-016-0253-9","article-title":"MicroRNA-29: a crucial player in fibrotic disease","volume":"21","author":"Deng Z","year":"2017","journal-title":"Mol Diagn Ther"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1161\/CIRCULATIONAHA.116.024171","article-title":"Inhibition of MicroRNA-146a and overexpression of its target dihydrolipoyl succinyltransferase protect against pressure overload-induced cardiac hypertrophy and dysfunction","volume":"136","author":"Heggermont WA","year":"2017","journal-title":"Circulation"},{"key":"ref15","first-page":"4223","article-title":"Enhanced plasma miR-26a-5p promotes the progression of bladder cancer via targeting PTEN","volume":"16","author":"Wang H","year":"2018","journal-title":"Oncol Lett"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s12094-016-1582-1","article-title":"miR-26a-5p suppresses tumor metastasis by regulating EMT and is associated with prognosis in HCC","volume":"19","author":"Chang L","year":"2017","journal-title":"Clin Transl Oncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1002\/jcb.28367","article-title":"microRNA-26a-5p affects myocardial injury induced by coronary microembolization by modulating HMGA1","volume":"120","author":"Kong B","year":"2019","journal-title":"J Cell Biochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/s41598-018-20561-4","article-title":"MiR-26a-5p regulates cardiac fibroblasts collagen expression by targeting ULK1","volume":"8","author":"Zheng L","year":"2018","journal-title":"Sci Rep"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.4049\/jimmunol.1700730","article-title":"Extracellular microRNAs induce potent innate immune responses via TLR7\/MyD88-dependent mechanisms","volume":"199","author":"Feng Y","year":"2017","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.yexcr.2007.12.009","article-title":"Krp1 (Sarcosin) promotes lateral fusion of myofibril assembly intermediates in cultured mouse cardiomyocytes","volume":"314","author":"Greenberg CC","year":"2008","journal-title":"Exp Cell Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"H1923","DOI":"10.1152\/ajpheart.00935.2003","article-title":"Differential contribution of necrosis and apoptosis in myocardial ischemia-reperfusion injury","volume":"286","author":"McCully JD","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fendo.2018.00338","article-title":"PTEN: tumor suppressor and metabolic regulator","volume":"9","author":"Chen CY","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref23","first-page":"209","article-title":"Clinical manifestations and basic mechanisms of myocardial ischemia\/reperfusion injury","volume":"30","author":"Yang CF","year":"2018","journal-title":"Ci Ji Yi Xue Za Zhi"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/CS20180465","article-title":"Histone acetylation and DNA methylation in ischemia\/reperfusion injury","volume":"133","author":"Tang J","year":"2019","journal-title":"Clin Sci (Lond)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.gpb.2012.10.001","article-title":"One decade of development and evolution of microRNA target prediction algorithms","volume":"10","author":"Reyes-Herrera PH","year":"2012","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2018.05.020","article-title":"MiR-26a-5p potentiates metastasis of human lung cancer cells by regulating ITGbeta8- JAK2\/STAT3 axis","volume":"501","author":"Song Q","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the PTEN tumour suppressor: new modes and prospects","volume":"19","author":"Lee YR","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1146\/annurev-biochem-082411-113907","article-title":"PTEN","volume":"83","author":"Worby CA","year":"2014","journal-title":"Annu Rev Biochem"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjmbr\/v53n2\/1414-431X-bjmbr-53-2-e9106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T01:40:52Z","timestamp":1611366052000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2020000200601&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020]]}},"alternative-id":["S0100-879X2020000200601"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x20199106","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e9106"}}