{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:44:15Z","timestamp":1773009855039,"version":"3.50.1"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz J Med Biol Res"],"DOI":"10.1590\/1414-431x2024e13389","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T10:34:20Z","timestamp":1714732460000},"source":"Crossref","is-referenced-by-count":5,"title":["Acupuncture for generalized anxiety disorder: a study protocol for a randomized controlled trial"],"prefix":"10.1590","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5460-3763","authenticated-orcid":false,"given":"Xiayun","family":"Zhou","sequence":"first","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4175-0743","authenticated-orcid":false,"given":"Guoao","family":"Shi","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-9488","authenticated-orcid":false,"given":"Ruiming","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0676-4493","authenticated-orcid":false,"given":"Lingsan","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6403-3667","authenticated-orcid":false,"given":"Zhongxian","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0049-7149","authenticated-orcid":false,"given":"Yifu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1126-7845","authenticated-orcid":false,"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6574-6039","authenticated-orcid":false,"given":"Xiang","family":"Ji","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3165-3595","authenticated-orcid":false,"given":"Min","family":"Peng","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8264-5368","authenticated-orcid":false,"given":"Kengyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2669-8702","authenticated-orcid":false,"given":"Luda","family":"Yan","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-4664","authenticated-orcid":false,"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou University of Traditional Chinese Medicine,  China; Guangzhou University of Chinese Medicine,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.24869\/psyd.2020.527","article-title":"Peer Education intervention on adolescents' anxiety, depression, and sleep disorder during the COVID-19 pandemic","volume":"32","author":"Ding X","year":"2020","journal-title":"Psychiatr Danub"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1017\/S2045796020000931","article-title":"Mental health problems and correlates among 746 217 college students during the coronavirus disease 2019 outbreak in China","volume":"29","author":"Ma Z","year":"2020","journal-title":"Epidemiol Psychiatr Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","article-title":"Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic","volume":"398","year":"2021","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1080\/08870446.2020.1782410","article-title":"COVID-19 related depression and anxiety among quarantined respondents","volume":"36","author":"Tang F","year":"2021","journal-title":"Psychol Health"},{"key":"ref5","first-page":"88","article-title":"Prevention and treatment of \u2018COVID-19 depression' [in Chinese]","volume":"8","author":"Zhen Xiao Gan","year":"2022","journal-title":"Prosecutorial Frontiers"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"310","DOI":"10.11622\/smedj.2015088","article-title":"Ministry of Health Clinical Practice Guidelines: anxiety disorders","volume":"56","author":"Lim L","year":"2015","journal-title":"Singapore Med J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.31887\/DCNS.2017.19.2\/dstein","article-title":"Epidemiology of anxiety disorders: from surveys to nosology and back","volume":"19","author":"Stein DJ","year":"2017","journal-title":"Dialogues Clin Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"113074","DOI":"10.1016\/j.psychres.2020.113074","article-title":"Relationships between stroke, depression, generalized anxiety disorder and physical disability: some evidence from the Canadian Community Health Survey-Mental Health","volume":"290","author":"Li X","year":"2020","journal-title":"Psychiatry Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11920-018-0923-x","article-title":"Moving to beat anxiety: epidemiology and therapeutic issues with physical activity for anxiety","volume":"20","author":"Kandola A","year":"2018","journal-title":"Curr Psychiatry Rep"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"580858","DOI":"10.3389\/fphar.2020.580858","article-title":"Comparative remission rates and tolerability of drugs for generalised anxiety disorder: a systematic review and network meta-analysis of double-blind randomized controlled trials","volume":"11","author":"Kong W","year":"2020","journal-title":"Front Pharmacol"},{"key":"ref11","first-page":"187","article-title":"Decrease of depression and outcome in treatment of anxiety disorders - an observational study of ROM data [in Dutch]","volume":"62","author":"Braam WH","year":"2020","journal-title":"Tijdschr Psychiatr"},{"key":"ref12","first-page":"1198","article-title":"Influence factors of anxiety and therapeutic effect of acupuncture intervention in isolated population under COVID-19 [in Chinese]","volume":"43","author":"Zhou Xiayun","year":"2023","journal-title":"Chin J Integrative Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e1000261","DOI":"10.1371\/journal.pmed.1000261","article-title":"Revised Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): extending the CONSORT statement","volume":"7","author":"MacPherson H","year":"2010","journal-title":"PLoS Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/ecam\/nep006","article-title":"WHO standard acupuncture point locations","volume":"7","author":"Lim S","year":"2010","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.neuroimage.2017.03.011","article-title":"Comparing GABA-dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-high-field MRI","volume":"152","author":"Dyke K","year":"2017","journal-title":"Neuroimage"},{"key":"ref16","article-title":"Clinical study on acupuncture treatment of generalized anxiety disorder based on the correlation of heart and brain [in Chinese]","author":"Huahua Liang","year":"2020","journal-title":"Gansu University of Traditional Chinese Medicine"},{"key":"ref17","first-page":"138","article-title":"Clinical observation on the treatment of liver-qi stagnation type depression with acupuncture combined with paroxetine [in Chinese]","volume":"36","author":"Li X","year":"2017","journal-title":"Shanghai Journal of Acupuncture and Moxibustion"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ctcp.2018.01.008","article-title":"Acupuncture and electroacupuncture for anxiety disorders: a systematic review of the clinical research","volume":"31","author":"Amorim D","year":"2018","journal-title":"Complement Ther Clin Pract"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jad.2014.06.041","article-title":"A systematic review of fMRI studies in generalized anxiety disorder: evaluating its neural and cognitive basis","volume":"167","author":"Mochcovitch MD","year":"2014","journal-title":"J Affect Disord"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1017\/S0033291710001455","article-title":"Attenuated responses to emotional expressions in women with generalized anxiety disorder","volume":"41","author":"Palm ME","year":"2011","journal-title":"Psychol Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1017\/S0033291712002383","article-title":"Prefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders","volume":"43","author":"Ball TM","year":"2013","journal-title":"Psychol Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s002210100863","article-title":"Comparison of descending volleys evoked by monophasic and biphasic magnetic stimulation of the motor cortex in conscious humans","volume":"141","author":"Di Lazzaro V","year":"2001","journal-title":"Exp Brain Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.clinph.2015.02.001","article-title":"Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee","volume":"126","author":"Rossini PM","year":"2015","journal-title":"Clin Neurophysiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1212\/WNL.42.10.1951","article-title":"Magnetic brain stimulation: the silent period after the motor evoked potential","volume":"42","author":"Cantello R","year":"1992","journal-title":"Neurology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.neubiorev.2008.09.010","article-title":"Cognitive control mechanisms, emotion and memory: a neural perspective with implications for psychopathology","volume":"33","author":"Banich MT","year":"2009","journal-title":"Neurosci Biobehav Rev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/cap.2009.0049","article-title":"A preliminary investigation of neural correlates of treatment in adolescents with generalized anxiety disorder","volume":"20","author":"Maslowsky J","year":"2010","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"ref27","article-title":"A study on the brain structure and functional characteristics of adolescents with generalized anxiety disorder [in Chinese]","author":"Liao Mei","year":"2013","journal-title":"Central South University"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1038\/tp.2011.46","article-title":"Deficient prefrontal attentional control in late-life generalized anxiety disorder: an fMRI investigation","volume":"1","author":"Price RB","year":"2011","journal-title":"Transl Psychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00406-010-0147-5","article-title":"Localized gray matter volume abnormalities in generalized anxiety disorder","volume":"261","author":"Schienle A","year":"2011","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/B978-0-444-64032-1.00037-0","article-title":"Transcranial magnetic stimulation","volume":"160","author":"Lefaucheur JP","year":"2019","journal-title":"Handb Clin Neurol"},{"key":"ref31","first-page":"131","article-title":"Cortical excitability and neurology: insights into the pathophysiology","volume":"27","author":"Badawy RA","year":"2012","journal-title":"Funct Neurol"},{"key":"ref32","article-title":"Magnetic resonance spectroscopy of prefrontal lobe in patients with generalized anxiety disorder [in Chinese]","author":"Hongtao Shao","year":"2021","journal-title":"Dali University"},{"key":"ref33","first-page":"821","article-title":"Fake acupuncture and placebo acupuncture in clinical research of acupuncture [in Chinese]","volume":"43","author":"Xiaoyu Liu","year":"2023","journal-title":"Zhongguo Zhen Jiu"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"966622","DOI":"10.3389\/fphar.2022.966622","article-title":"Pharmacokinetics of immediate and sustained-release formulations of paroxetine: population pharmacokinetic approach to guide paroxetine personalized therapy in chinese psychotic patients","volume":"13","author":"Li XL","year":"2022","journal-title":"Front Pharmacol"}],"container-title":["Brazilian Journal of Medical and Biological Research"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0100-879X2024000100401&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T10:34:38Z","timestamp":1714732478000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-879X2024000100401&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":34,"alternative-id":["S0100-879X2024000100401"],"URL":"https:\/\/doi.org\/10.1590\/1414-431x2024e13389","relation":{},"ISSN":["1414-431X","0100-879X"],"issn-type":[{"value":"1414-431X","type":"electronic"},{"value":"0100-879X","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e13389"}}