{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:28:03Z","timestamp":1758893283559},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sao Paulo Med. J."],"abstract":"<jats:p>ABSTRACT CONTEXT AND OBJECTIVE: In 2004, the Brazilian National Health Surveillance Agency (Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria, ANVISA) published a resolution establishing guidelines for albumin use. Although the published data do not indicate any definitive conclusions about the benefits of albumin use in patients with nephrotic syndrome (NS), the guidelines recommend this procedure only in cases of edema that is refractory to use of diuretics. The aim here was to analyze albumin use among patients with nephrotic syndrome. DESIGN AND SETTING: Pharmacoeconomic study conducted in four large public referral hospitals for nephrology services in northeastern Brazil. METHOD: Cost-effectiveness and cost-utility economic evaluations were performed on a concurrent cohort of patients with nephrotic syndrome, who were divided into two groups according to compliance or noncompliance with the guidelines. Quality-of-life data were obtained from the SF36 and CHQ-PF50 questionnaires. RESULTS: This study enrolled 109 patients (60% adults and 56% women); 41.3% were using albumin in accordance with the guidelines. The weight, diuresis and fluid balance parameters were more cost-effective for patients who adhered to the guidelines. Regarding days of hospitalization avoided, the incremental ratio showed a daily cost of R$ 55.33, and guideline-compliant patients were hospitalized for five days or fewer. The quality of life improved by 8%, and savings of R$ 3,458.13\/QALY (quality-adjusted life year) for the healthcare system were generated through guideline compliance. CONCLUSION: The economic analyses of this study demonstrated that there were greater cost benefits for patients whose treatment followed the guidelines.<\/jats:p>","DOI":"10.1590\/1516-3180.2016.0048030516","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T12:41:22Z","timestamp":1492692082000},"page":"92-99","source":"Crossref","is-referenced-by-count":1,"title":["Economic evaluation of human albumin use in patients with nephrotic syndrome in four Brazilian public hospitals: pharmacoeconomic study"],"prefix":"10.1590","volume":"135","author":[{"given":"Leonardo Augusto Kister de","family":"Toledo","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio Carlos Beisl","family":"Noblat","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrison Floriano do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Professor Edgard Santos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia de Ara\u00fajo Costa Beisl","family":"Noblat","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"ref1","series-title":"Avalia\u00e7\u00e3o econ\u00f4mica em sa\u00fade: desafios para gest\u00e3o no Sistema \u00danico de Sa\u00fade","year":"2008"},{"key":"ref2","series-title":"Diretrizes Metodol\u00f3gicas: estudos de avalia\u00e7\u00e3o econ\u00f4mica de tecnologias em sa\u00fade","year":"2009"},{"key":"ref3","series-title":"Methods for the economic evaluation of health care programmes","author":"Drummond MF","year":"1997"},{"key":"ref4","series-title":"Introdu\u00e7\u00e3o \u00e0 farmacoeconomia","author":"Rascati KL","year":"2010"},{"key":"ref5","series-title":"Cost effectiveness in health and medicine","author":"Gold MR","year":"1996"},{"key":"ref6","series-title":"Protocolos cl\u00ednicos e diretrizes terap\u00eauticas","year":"2010"},{"key":"ref7","article-title":"Resolu\u00e7\u00e3o RDC no 115, de 10 de mar\u00e7o de 2004. Aprova as Diretrizes para o uso de Albumina","year":"2004","journal-title":"D. O. U. - Di\u00e1rio Oficial da Uni\u00e3o"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/jama.1977.03270310039005","article-title":"Albumin 1. Background and use","volume":"237","author":"Tullis JL","year":"1977","journal-title":"JAMA"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jama.1977.03270320038019","article-title":"Albumin 2. Guidelines for critical use","volume":"237","author":"Tullis JL","year":"1977","journal-title":"JAMA"},{"key":"ref10","series-title":"Estudo de utiliza\u00e7\u00e3o da albumina humana em hospitais do Rio de Janeiro, Brasil","author":"Matos GC","year":"2006"},{"key":"ref11","series-title":"Plano anual de atividades de auditoria interna exerc\u00edcio de 2012","year":"2012"},{"issue":"2","key":"ref12","first-page":"131","article-title":"S\u00edndrome nefr\u00f3tica primaria em adultos [Primary nephrotic syndrome in adults]","volume":"30","author":"Veronese FV","year":"2010","journal-title":"Revista HCPA"},{"issue":"3","key":"ref13","first-page":"471","article-title":"Co-administration of albumin-furosemide in patients with the nephrotic syndrome","volume":"22","author":"Ghafari A","year":"2011","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"2","key":"ref14","first-page":"10","article-title":"Tratamento da glomerulopatias prim\u00e1rias","volume":"27","year":"2005","journal-title":"Jornal Brasileiro de Nefrologia"},{"issue":"23","key":"ref15","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1056\/NEJM199804233381707","article-title":"The nephrotic syndrome","volume":"338","author":"Orth SR","year":"1998","journal-title":"N Engl J Med"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00467-013-2567-8","article-title":"The nephrotic syndrome: pathogenesis and treatment of edema formation and secondary complications","volume":"29","author":"Cadnapaphornchai MA","year":"2013","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1345\/aph.1C320","article-title":"Combined furosemide and human albumin treatment for diuretic-resistant edema","volume":"37","author":"Elwell RJ","year":"2003","journal-title":"Ann Pharmacother"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1523-1755.1999.00298.x","article-title":"Coadministration of albumin and furosemide in patients with the nephrotic syndrome","volume":"55","author":"Fliser D","year":"1999","journal-title":"Kidney Int"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s004670100576","article-title":"Does albumin and furosemide therapy affect plasma volume in nephrotic children?","volume":"16","author":"Bircan Z","year":"2001","journal-title":"Pediatr Nephrol"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00003643-200310000-00003","article-title":"Albumin administration--what is the evidence of clinical benefit? A systematic review of randomized controlled trials","volume":"20","author":"Haynes GR","year":"2003","journal-title":"Eur J Anaesthesiol"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00467-008-1062-0","article-title":"Randomized cross-over trial comparing albumin and frusemide infusions in nephrotic syndrome","volume":"24","author":"Dharmaraj R","year":"2009","journal-title":"Pediatr Nephrol"},{"issue":"6973","key":"ref22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/bmj.310.6973.162","article-title":"Diuretic effect of frusemide in patients with nephrotic syndrome: is it potentiated by intravenous albumin?","volume":"310","author":"Akcicek F","year":"1995","journal-title":"BMJ"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3346\/jkms.2001.16.4.448","article-title":"Does albumin preinfusion potentiate diuretic action of furosemide in patients with nephrotic syndrome?","volume":"16","author":"Na KY","year":"2001","journal-title":"J Korean Med Sci"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4037\/ajcc2012999","article-title":"Effect of albumin on diuretic response to furosemide in patients with hypoalbuminemia","volume":"21","author":"Doungngern T","year":"2012","journal-title":"Am J Crit Care"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jcrc.2013.10.004","article-title":"Co-administration of furosemide with albumin for overcoming diuretic resistance in patients with hypoalbuminemia: a meta-analysis","volume":"29","author":"Kitsios GD","year":"2014","journal-title":"J Crit Care"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1542\/peds.91.6.1142","article-title":"Efficacy of albumin and diuretic therapy in children with nephrotic syndrome","volume":"91","author":"Haws RM","year":"1993","journal-title":"Pediatrics"},{"issue":"5","key":"ref27","first-page":"299","article-title":"[The effect of albumin and furosemide administration in children with primary nephrotic syndrome (author's transl)]","volume":"10","author":"Rego Filho E de A","year":"1977","journal-title":"Rev Bras Pesqui Med Biol"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware Jr JE","year":"1992","journal-title":"Med Care"},{"issue":"3","key":"ref29","first-page":"143","article-title":"Tradu\u00e7\u00e3o para a l\u00edngua portuguesa e valida\u00e7\u00e3o do question\u00e1rio gen\u00e9rico de avalia\u00e7\u00e3o de qualidade de vida SF-36 (Brasil SF-36) [Brazilian-Portuguese version of the SF-36. A reliable and valid quality of life outcome measure]","volume":"39","author":"Ciconelli RM","year":"1999","journal-title":"Rev Bras Reumatol"},{"key":"ref30","series-title":"The Child Health Questionnaire: s user's manual","author":"Landgraf JM","year":"1999"},{"issue":"4","key":"ref31","first-page":"S25","article-title":"The Brazilian version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)","volume":"19","author":"Machado CS","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"ref32","series-title":"Adapta\u00e7\u00e3o e valida\u00e7\u00e3o para a l\u00edngua portuguesa do question\u00e1rio gen\u00e9rico de avalia\u00e7\u00e3o de qualidade de vida - \"50-item, parent complete short form, Child Health Questionnaire\" (CHQ-PF50)","author":"Gomes DC.","year":"2001"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0167-6296(01)00130-8","article-title":"The estimation of a preference-based measure of health from the SF-36","volume":"21","author":"Brazier J","year":"2002","journal-title":"J Health Econ"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ejim.2013.05.015","article-title":"Clinical indications for the albumin use: still a controversial issue","volume":"24","author":"Caraceni P","year":"2013","journal-title":"Eur J Intern Med"},{"issue":"2","key":"ref35","first-page":"371","article-title":"Co-administration of albumin and furosemide in patients with the nephrotic syndrome","volume":"23","author":"Hari P","year":"2012","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7326\/0003-4819-135-9-200111060-00012","article-title":"Clinical inertia","volume":"135","author":"Phillips LS","year":"2001","journal-title":"Ann Intern Med"},{"key":"ref37","series-title":"Protocolos cl\u00ednicos: ades\u00e3o e aplicabilidade numa institui\u00e7\u00e3o hospitalar. Rio Grande do Sul","author":"Mahmud SDP","year":"2002"},{"key":"ref38","series-title":"Censo Demogr\u00e1fico 2010. Caracter\u00edsticas gerais da popula\u00e7\u00e3o, religi\u00e3o e pessoas com defici\u00eancia","year":"2010"},{"key":"ref39","series-title":"Consulta P\u00fablica no 6, de 12 de mar\u00e7o de 2014. Submete \u00e0 Consulta P\u00fablica os crit\u00e9rios e par\u00e2metros assistenciais de planejamento e programa\u00e7\u00e3o de a\u00e7\u00f5es e servi\u00e7os de sa\u00fade no \u00e2mbito do Sistema \u00danico de Sa\u00fade. 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