{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:21:17Z","timestamp":1766427677822,"version":"3.37.3"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sao Paulo Med. J."],"DOI":"10.1590\/1516-3180.2018.0489220719","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T14:19:26Z","timestamp":1583504366000},"page":"517-522","source":"Crossref","is-referenced-by-count":7,"title":["Tocilizumab for juvenile idiopathic arthritis: a single-center case series"],"prefix":"10.1590","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6483-8978","authenticated-orcid":false,"given":"Fatma","family":"Yaz\u0131l\u0131ta\u015f","sequence":"first","affiliation":[{"name":"Sa\u011flik Bilimleri \u00dcniversitesi, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-4595","authenticated-orcid":false,"given":"Semanur","family":"\u00d6zdel","sequence":"additional","affiliation":[{"name":"Sa\u011flik Bilimleri \u00dcniversitesi, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8339-9704","authenticated-orcid":false,"given":"Do\u011fan","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Sa\u011flik Bilimleri \u00dcniversitesi, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-7226","authenticated-orcid":false,"given":"\u00d6zlem","family":"Aydo\u011f","sequence":"additional","affiliation":[{"name":"Ondokuz Mayis \u00dcniversitesi Tip Fak\u00fcltesi, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-6206","authenticated-orcid":false,"given":"Evrim Karg\u0131n","family":"\u00c7ak\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Sa\u011flik Bilimleri \u00dcniversitesi, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5851-8676","authenticated-orcid":false,"given":"G\u00f6k\u00e7e G\u00fcr","family":"Can","sequence":"additional","affiliation":[{"name":"Sa\u011flik Bilimleri \u00dcniversitesi, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-1565","authenticated-orcid":false,"given":"T\u00fclin","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[{"name":"Sa\u011flik Bilimleri \u00dcniversitesi, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9007-9653","authenticated-orcid":false,"given":"Mehmet","family":"B\u00fclb\u00fcl","sequence":"additional","affiliation":[{"name":"Sa\u011flik Bilimleri \u00dcniversitesi"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,12]]},"reference":[{"issue":"9563","key":"ref1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","article-title":"Juvenile idiopathic arthritis","volume":"369","author":"Ravelli A","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12098-015-1966-1","article-title":"Management of Children with Juvenile Idiopathic Arthritis","volume":"83","author":"Viswanathan V","year":"2016","journal-title":"Indian J Pediatr"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4274\/balkanmedj.2017.0111","article-title":"Juvenile Idiopathic Arthritis","volume":"34","author":"Barut K","year":"2017","journal-title":"Balkan Med J"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.autrev.2012.07.022","article-title":"Systemic juvenile idiopathic arthritis","volume":"12","author":"Martini A","year":"2012","journal-title":"Autoimmun Rev"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2174\/09298673113206660303","article-title":"An update on autoinflammatory diseases","volume":"21","author":"Ciccarelli F","year":"2014","journal-title":"Curr Med Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1546-0096-12-13","article-title":"Treatment of juvenile idiopathic arthritis: a revolution in care","volume":"12","author":"Stoll ML","year":"2014","journal-title":"Pediatr Rheumatol Online J"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ghir.2008.01.006","article-title":"Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis","volume":"18","author":"Wong SC","year":"2008","journal-title":"Growth Horm IGF Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"271569","DOI":"10.1155\/2012\/271569","article-title":"Systemic arthritis in children: a review of clinical presentation and treatment","volume":"2012","author":"Gurion R","year":"2012","journal-title":"Int J Inflam"},{"issue":"5","key":"ref9","first-page":"493","article-title":"Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis","volume":"10","author":"De Benedetti F","year":"1992","journal-title":"Clin Exp Rheumatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13554-012-0001-6","article-title":"Treatment of Systemic Juvenile Idiopathic Arthritis with Tocilizumab - the Role of Anti-Interleukin-6 Therapy After a Decade of Treatment","volume":"2","author":"Reiff A","year":"2012","journal-title":"Biol Ther"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1158\/0008-5472.CAN-06-3641","article-title":"Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor","volume":"67","author":"Yoshio-Hoshino N","year":"2007","journal-title":"Cancer Res"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"R1281","DOI":"10.1186\/ar1826","article-title":"Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement","volume":"7","author":"Woo P","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/art.20944","article-title":"Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis","volume":"52","author":"Yokota S","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"9617","key":"ref14","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0140-6736(08)60454-7","article-title":"Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial","volume":"371","author":"Yokota S","year":"2008","journal-title":"Lancet"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1136\/annrheumdis-2014-205351","article-title":"Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial","volume":"74","author":"Brunner HI","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"ref16","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/acr.22259","article-title":"Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for new-onset polyarticular juvenile idiopathic arthritis","volume":"66","author":"Ringold S","year":"2014","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/acr.21625","article-title":"Consensus treatment plans for new-onset systemic juvenile idiopathic arthritis","volume":"64","author":"DeWitt EM","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/acr.22087","article-title":"2013 update of the 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications","volume":"65","author":"Ringold S","year":"2013","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jpeds.2004.12.016","article-title":"Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis","volume":"146","author":"Ravelli A","year":"2005","journal-title":"J Pediatr"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/acr.20460","article-title":"2011 American College of Rheumatology Recommendations for the Treatment of Juvenile Idiopathic Arthritis: Initiation and Safety Monitoring of Therapeutic Agents for the Treatment of Arthritis and Systemic Features","volume":"63","author":"Beukelman T","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/s10165-011-0481-0","article-title":"Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis","volume":"22","author":"Imagawa T","year":"2012","journal-title":"Mod Rheumatol"},{"issue":"3","key":"ref23","first-page":"260","article-title":"Biologicals in Juvenile Idiopathic Arthritis","volume":"53","author":"Saini I","year":"2016","journal-title":"Indian Pediatr"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/1759720X12455960","article-title":"Efficacy safety and tolerability of tocilizumab in patients with systemic juvenile arthritis","volume":"4","author":"Yokota S","year":"2012","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/17512433.2017.1300058","article-title":"Clinical pharmacology of tocilizumab for the treatment of polyarticular-course juvenile idiopathic arthritis","volume":"10","author":"Zhang X","year":"2017","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/14740338.2017.1303479","article-title":"Safety of tocilizumab in the treatment of juvenile idiopathic arthritis","volume":"16","author":"Machado SH","year":"2017","journal-title":"Expert Opin Drug Saf"},{"issue":"9","key":"ref27","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1136\/annrheumdis-2015-207818","article-title":"Tocilizumab in systemic juvenile idiopathic arthritis in a real-world clinical setting: results from 1 year of postmarketing surveillance follow-up of 417 patients in Japan","volume":"75","author":"Yokota S","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s40272-013-0053-1","article-title":"Tocilizumab: a review of its use in the treatment of juvenile idiopathic arthritis.","volume":"15","author":"Frampton JE","year":"2013","journal-title":"Paediatr Drugs"},{"issue":"7","key":"ref29","first-page":"11337","article-title":"Correlation of mean platelet volume, neutrophil-to-lymphocyte ratio, and disease activity in children with juvenile idiopathic arthritis","volume":"8","author":"G\u00fcne\u015f A","year":"2015","journal-title":"Int J Clin Exp Med"}],"container-title":["Sao Paulo Medical Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/spmj\/v137n6\/1806-9460-spmj-137-06-517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T19:07:22Z","timestamp":1722539242000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1516-31802019000600517&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["S1516-31802019000600517"],"URL":"https:\/\/doi.org\/10.1590\/1516-3180.2018.0489220719","relation":{},"ISSN":["1806-9460","1516-3180"],"issn-type":[{"type":"electronic","value":"1806-9460"},{"type":"print","value":"1516-3180"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}