{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:20:18Z","timestamp":1787984418854,"version":"build-2784847793"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Latino-Am. Enfermagem"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Abstract  Objective:  to assessed the prevalence of diabetes mellitus (DM) and drug abuse in mothers of children with orofacial clefts (OFC).  Methods:  325 women who had children (0-3y) with clefts were interviewed. Data regarding type of diabetes, use of legal\/illegal drugs during pregnancy, waist girth and fasting blood sugar at the first prenatal consult were collected.  Results:  twenty seven percent of the women had DM, out of these, 89% had gestational DM, 5,5% type 1 DM and 5,5% type 2 DM. The prevalence of DM in mothers of children with OFC was 27%, it is significantly higher than the average Brazilian population which is 7.6% (p&lt;0.01) (OR=4.5, 95%CI=3.5-5.8). Regarding drug abuse during pregnancy, 32% of the mothers used drugs and a significant positive correlation was observed between drug abuse and the occurrence of clefts and other craniofacial anomalies (p=0.028) (OR=2.87; 95%CI=1.1-7.4).  Conclusions:  DM and drug abuse during pregnancy increases the risk for OFC and related anomalies and early diagnosis of DM and prevention of drug abuse, especially in pregnant women, should be emphasized.<\/jats:p>","DOI":"10.1590\/1518-8345.0815.2701","type":"journal-article","created":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T12:51:05Z","timestamp":1470487865000},"source":"Crossref","is-referenced-by-count":12,"title":["Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities"],"prefix":"10.1590","volume":"24","author":[{"given":"Ivy Kiemle","family":"Trindade-Suedam","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edlia Maria von","family":"Kostrisch","sequence":"additional","affiliation":[{"name":"Secretaria de Municipal de Sa\u00fade de Fortaleza,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Andr\u00e9 Freire","family":"Pimenta","sequence":"additional","affiliation":[{"name":"University of North Carolina,  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Ant\u00f4nio","family":"Negrato","sequence":"additional","affiliation":[{"name":",  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange Braga","family":"Franzolin","sequence":"additional","affiliation":[{"name":"Universidade Sagrado Cora\u00e7\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alceu Sergio","family":"Trindade Junior","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"1","article-title":"Risk factors associated with metabolic syndrome in type 2 diabetes mellitus patients according to World Health Organization, Third Report National Cholesterol Education Program, and International Diabetes Federation definitions","volume":"4","author":"Rodr\u00edguez A","year":"2011","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata L","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/diacare.15.11.1509","article-title":"Multicenter study of the prevalence of diabetes mellitus and impaired glucose tolerance in the urban Brazilian population aged 30-69 yr","volume":"15","author":"Malerbi DA","year":"1992","journal-title":"Diabetes Care"},{"key":"ref4","series-title":"Vigitel Brasil 2010: vigil\u00e2ncia de fatores de risco e prote\u00e7\u00e3o para doen\u00e7as cr\u00f4nicas por inqu\u00e9rito telef\u00f4nico","first-page":"il","year":"2011"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/00001648-200011000-00013","article-title":"A prospective study of the risk of congenital defects associated with maternal obesity and diabetes mellitus","volume":"11","author":"Moore LL","year":"2000","journal-title":"Epidemiology"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1080\/00016340802334377","article-title":"Detection of pregnancies with high risk of fetal macrosomia among women with gestational diabetes mellitus","volume":"87","author":"Suhonen L","year":"2008","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/EDE.0b013e31818e5930","article-title":"Maternal Periconceptional Illicit Drug abuse and the Risk of Congenital Malformations","volume":"20","author":"van Gelder MMHJ","year":"2009","journal-title":"Epidemiology"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"314e1","DOI":"10.1016\/j.ajog.2010.12.039","article-title":"Maternal treatment with opioid analgesics and risk for birth defects","volume":"204","author":"Broussard CS","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-0031-1277713","article-title":"Types of clefts and multianomaly craniofacial conditions","volume":"32","author":"Peterson-Falzone SJ","year":"2011","journal-title":"Semin Speech Lang"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1597\/10-133","article-title":"NigeriaCRAN Collaboration. Genetic studies in the Nigerian population implicate an MSX1 mutation in complex oral facial clefting disorders","volume":"48","author":"Butali A","year":"2011","journal-title":"Cleft Palate Craniofac J"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajhg.2011.01.003","article-title":"FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish","volume":"88","author":"Ghassibe-Sabbagh M","year":"2011","journal-title":"Am J Hum Genet"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/ng.2360","article-title":"Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci","volume":"44","author":"Ludwig KU","year":"2012","journal-title":"Nat Genet"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116963","article-title":"Passive smoking in the etiology of non-syndromic orofacial clefts: a systematic review and meta-analysis","volume":"10","author":"Sabbagh HJ","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00000637-200111000-00001","article-title":"Association between maternal diabetes mellitus and newborn oral cleft","volume":"47","author":"Spilson SV","year":"2001","journal-title":"Ann Plast Surg"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"585. e1","DOI":"10.1016\/j.ajog.2007.05.046","article-title":"Maternal corticosteroid use and orofacial clefts.","volume":"197","author":"Carmichael SL","year":"2007","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/pds.2179","article-title":"Maternal use of antibiotics and the risk of orofacial clefts: a nationwide cohort study","volume":"21","author":"Molgaard-Nielsen D","year":"2012","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MLG.0b013e3181587d7c","article-title":"Waist circumference and sleep disordered breathing","volume":"118","author":"Davidson TM","year":"2008","journal-title":"Laryngoscope"},{"key":"ref18"},{"key":"ref19","series-title":"The International Standard Classification of Education (ISCED) - 2011, from the United Nations Educational, Scientific and Cultural Organization (UNESCO)"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/bdra.23060","article-title":"Nitrosatable drug exposure during the first trimester of pregnancy and selected congenital malformations","volume":"94","author":"Brender JD","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/aje\/kwm146","article-title":"Maternal periconceptional alcohol consumption and risk of orofacial clefts","volume":"166","author":"Romitti PA","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/oby.20307","article-title":"Differential associations of abdominal visceral, subcutaneous adipose tissue with cardiometabolic risk factors between African and European Americans","volume":"22","author":"Liu J","year":"2014","journal-title":"Obesity"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/AOG.0b013e31825f21ff","article-title":"Metabolic syndrome as a risk factor for hypertension after preeclampsia","volume":"120","author":"Spaan JJ","year":"2012","journal-title":"Obstet Gynecol"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bdrb.20062","article-title":"Reduction in diabetes-induced craniofacial defects by maternal immune stimulation","volume":"77","author":"Hrubec TC","year":"2006","journal-title":"Birth Defect Res B Dev Reprod Toxicol"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000081958","article-title":"Anxiety, depression, and quality of life in mothers of children with cleft lip\/palate","volume":"57","author":"Weigl V","year":"2005","journal-title":"Folia Phoniatr Logop"}],"container-title":["Revista Latino-Americana de Enfermagem"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rlae\/v24\/0104-1169-rlae-24-02701.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T23:59:12Z","timestamp":1495583952000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-11692016000100354&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":25,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2016]]}},"alternative-id":["S0104-11692016000100354"],"URL":"https:\/\/doi.org\/10.1590\/1518-8345.0815.2701","relation":{},"ISSN":["0104-1169"],"issn-type":[{"value":"0104-1169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}